梁鑫 博士

研究员/Tenure Track助理教授

1999-2003       学士                上海交通大学

2003-2007       博士                上海交通大学

2008-2014       博士后            马克思-普朗克分子细胞生物学和遗传学研究所

2009-2011       洪堡学者       

2015-               研究员/Tenure Track助理教授         清华大学生命科学学院

 

● 研究兴趣、领域:

主要应用生物物理的概念和方法研究细胞对机械力信号的感觉机制。具体的研究内容包括:(1)机械力敏感神经元中力信号传导通路的分子基础;(2)机械力敏感神经元对不同力信号选择性响应的细胞和分子生物学机制;(3)细胞骨架动力学的分子基础及其在细胞形态和细胞力学中的作用。研究手段包括电子显微镜,光学显微镜,果蝇遗传学,分子生物学和生物化学等。

● 代表性论文:

1. Liang X, Madrid J, Howard J, The Microtubule-based Cytoskeleton is a Component of a Mechanical Signaling Pathway in Fly Mechanoreceptors. Biophysical Journal. 2014 Dec 16; 107(12): 2767-74.

2. Liang X, Madrid J, G?rtner R, Verbavatz JM, Schiklenk C, Wilsch-Br?uninger M, Bogdanova A, Stenger F, Voigt A, Howard J, A NOMPC-dependent membrane-microtubule connector is a candidate of the gating spring in fly mechanoreceptors. Current Biology. 2013 May 6; 23 (9):755-63.

3. Liang X, Madrid J, Saleh HS, Howard J. NOMPC, a member of the TRP channel family, localizes to the tubular body and distal cilium of Drosophila campaniform and chordotonal receptor cells. Cytoskeleton. 2011 Jan; 68(1):1-7. (Cover of Vol. 68, Iss. 2, Feb. 2011.)

4. Liang X, Hu XF, Hu J. Dynamic inter-receptor coupling contributes to the consistent open duration of ryanodine receptors. Biophysical Journal. 2009 Jun 17; 96(12): 4826-33.

5.  Liang X, Hu XF, Hu J. Dynamic inter-receptor coupling: a novel working mechanism of two dimensional ryanodine receptor array. Biophysical Journal. 2007 Feb 15;92 (4):1215-23.

6. Liang X, Chen K, Fruen B, Hu J, Ma J, Hu X, Parness J., Impaired interaction between skeletal ryanodine receptors in malignant hyperthermia. Integrative Biology, 2009, 1, 533-539.

7. Liang X*, Sun LD and Liu Z, Mechanosensory Transduction in Drosophila Melanogaster. BOOK ISBN: 978-981-10-6525-5. DOI: 10.1007/978-981-10-6526-2. Springer.

8. Liang X*, Howard J, Structural Biology: A Force-Sensitive Ion Channel Springs to Life. Current Biology. 2017 Sep 25;27(18):R1017-R1020.

9. Feng S, Song Y, Shen M, Xie S, Li W, Lu Y, Yang Y, Ou G, Zhou J, Wang F, Liu W, Yan X, Liang X*, Zhou T*. Microtubule-binding protein FOR20 promotes microtubule depolymerization and cell migrationCell Discovery. 2017 Sep 5;3:17032.

 

● 荣誉、奖励及参加学术团体的情况:

2015-               马普伙伴小组奖励计划   

● 联系方式:

E-mail: xinliang@mail.tsinghua.edu.cn

Tel: 010-62772563(office)   010-62771231(lab)