王一国 博士

研究员,青年千人,优秀青年基金,国家杰出青年基金获得者

1997.9-2001.7       曲阜师范大学生命科学学院 学士

2001.9-2007.1       中科院上海生物化学与细胞生物学研究所     博士

2007.8-2012.8       美国索儿克研究所   博士后

2012.8-            清华大学生命科学学院  研究员

 

● 研究兴趣、领域:

能量稳态的激素与营养信号调控

 

● 代表性论文:

1.    Jinbo Han#, Erwei Li#, Liqun Chen, Yuanyuan Zhang, Fangchao Wei, Jieyuan Liu, Haiteng Deng and Yiguo Wang*. The CREB Coactivator CRTC2 Controls Hepatic Lipid Metabolism by Regulating SREBP1. Nature (2015) 524 (7564): 243-246.

2.    Yiguo Wang, Gang Li, Jason Goode, Jose C. Paz, Kunfu Ouyang, Robert Screaton, Wolfgang H. Fischer, Ju Chen, Ira Tabas and Marc Montminy. InsP3 Receptor Regulates Hepatic Gluconeogenesis in Fasting and Diabetes. Nature (2012) 485 (7396): 128-132.

3.    Yiguo Wang, Hiroshi Inoue, Kim Ravnskjaer, Kristin Viste, Nina Miller, Yi Liu, Susan Hedrick, Liliana Vera, and Marc Montminy. Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. Proc Natl Acad Sci U S A. (2010) 107 (7): 3087-3092.

4.    Yiguo Wang, Liliana Vera, Wolfgang H Fischer, Marc Montminy. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature (2009) 460 (7254): 534-537.

5.    Yiguo Wang, Dan Du, Longhou Fang, Guang Yang, Chenyi Zhang, Rong Zeng, Axel Ullrich, Friedrich Lottspeich, Zhengjun Chen.  Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling.  The EMBO Journal. (2006) 25, 5058-5070.

6.    Liqun Chen*, Ke Wang*, Aijun Long, Liangjie Jia, Yuanyuan Zhang, Haiteng Deng, Yu Li, Jinbo Han and Yiguo Wang. (2017). Fasting-induced hormonal regulation of lysosomal function. Cell Res. 27, 748-763.


● 联系方式:

电话:+86-10-62783209

E-mail: wangyiguo@biomed.tsinghua.edu.cn