王耿 博士

研究员,青年千人

1994-1998年,厦门大学化学系 学士

1998-2000年,厦门大学化学系

2000-2006年,爱荷华大学生物化学系 博士

2006-2012年,加州大学洛杉矶分校化学与生物化学系 博士后

2012-至今, 清华大学生命科学学院 研究员

 

● 研究兴趣、领域:

1)线粒体RNA的运输、代谢、和功能,及其和其他重要细胞过程如衰老和细胞凋亡之间的关联和调控。

2)线粒体疾病的医疗研究。

 

● 代表性论文:

von Ameln S., G. Wang, R. Boulouiz, M.A. Rutherford, G.M. Smith, Y. Li, . Pogoda, G. Nürnberg, A.E. Volk, B. Stiller, R.J. Goodyear, P. Nürnberg, G.P. Richardson, M. Hammerschmidt, T. Moser, B. Wollnik, C.M. Koehler, M.A. Teitell, A. Barakat, C. Kubisch*. 2012.An indispensable role of the mitochondrial RNA-import protein PNPase for human auditory function. Am. J. Hum. Genet. 91(5):919.

Wang G., E. Shimada, J. Zhang, G.M. Smith, J.S. Hong, M.A. Teitell, C.M. Koehler*. 2012. A Novel Approach for Restoring the Functions of Mutant Mitochondria in Human Cells. Proc. Natl. Acad. Sci. U.S.A. 109(13):4840-5.

Wang G., E. Shimada, C.M. Koehler, and M.A. Teitell*. 2012. PNPASE and RNA Trafficking into Mitochondria. Biochim. Biophys. Acta. 1819(9-10):998-1007.

Zhang J., I. Khvorostov, J. Hong, Y. Oktay, L. Vergnes, E. Nuebel, P. Wahjudi, G. Wang, A. Do, H, Jung, J.M. McCaffery, I. Kurland, K. Reue, W.N.P. Lee, C.M. Koehler, M.A. Teitell*. 2011, UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells. EMBO J. 30(24):4860.

 Wang G., H. Chen, Y. Oktay, J. Zhang, E.L. Allen, G.M. Smith, K.C. Fan, J.S. Hong, S.W. French, J.M. McCaffery, R.N. Lightowlers, H.C. Morse III, C.M. Koehler, and M.A. Teitell*. 2010. PNPASE Regulates RNA Import into Mitochondria. Cell 142:456.

Wang, G., R. Deschenes*, 2006. Plasma membrane localization of Ras requires Class C Vps proteins and functional mitochondria in Saccharomyces cerevisiae. Mol. Cell. Biol. 26:3243. 

Liu P, Huang J, Zheng Q, Xie L, Lu X, Jin J, Wang G (2017) Mammalian mitochondrial RNAs are degraded in the mitochondrial intermembrane space by RNASET2. Protein & Cell 8(1): 735-749

Wang G, Shimada E, Nili M, Koehler CM, Teitell MA (2015) Mitochondria-targeted RNA import. Methods Mol Biol. 1264:107-116

 

● 联系方式:

电话: +86-010-62783944

E-mail: wangeng@hotmail.com