吴畏 博士

教授, 博士生导师

1987-1991,四川大学,获学士学位  

1991-1994,四川大学,获硕士学位

1994-1996,中国科学院微生物研究所,实习研究员

1996-2001,德国海德堡大学,获博士学位

2001-2005,   德国癌症研究中心,博士后

2005-现在,   清华大学教授

● 研究兴趣、领域:

Wnt信号调控细胞生长、增殖和分化等,在组织稳态维持以及肿瘤发生中发挥重要作用。我们实验室利用细胞培养,3D类器官(organoid)培养以及小鼠为系统, 结合化学生物学手段,研究Wnt信号在成体肠干细胞介导的组织稳态维持和肿瘤发生中的功能和调控机制。

● 代表性论文:

1.        Zhu G, Fan Z, Ding M, Zhang H, Mu L, Ding Y, Zhang Y, Jia B, Chen L, Chang Z, Wu W. An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis. Oncogene. 2015 Mar 9.

2.        Ding Y, Su S, Tang W, Zhang X, Chen S, Zhu G, Liang J, Wei W, Guo Y, Liu L, Chen YG, Wu W. Enrichment of the β-catenin-TCF complex at the S and G2 phases ensures cell survival and cell cycle progression. J Cell Sci. 2014 Nov 15;127(22):4833-45.

3.        Zhu G, Fan Z, Ding M, Mu L, Liang J, Ding Y, Fu Y, Huang B, Wu W. DNA Damage Induces the Accumulation of Tiam1 by Blocking β-TrCP-dependent Degradation. J Biol Chem. 2014 May 30;289(22):15482-15494.

4.        Su X, Zhu G, Ding X, Lee SY, Dou Y, Zhu B, Wu W#, and Li H#. Molecular basis underlyinghistone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1. Genes Dev. 2014 Mar 15;28(6):622-36. (#: co-corresponding author) (Featured by F1000)

5.        Fu Y, Huang B, Shi Z, Han J, Wang Y, Huangfu J, Wu W. SRSF1 and SRSF9 RNA binding proteins promote Wnt signaling-mediated tumorigenesis by enhancing β-catenin biosynthesis. EMBO Mol Med. 2013 May;5(5):737-50.

6.        Zhu G, Wang Y, Huang B, Liang J, Ding Y, Xu A, Wu W. A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells. Oncogene. 2012 Feb 23;31(8):1001-12.

7.        Liang J, Fu Y, Cruciat CM, Jia S, Wang Y, Tong Z, Tao Q, Ingelfinger D, Boutros M, Meng A, Niehrs C, Wu W. Transmembrane Protein 198 Promotes LRP6 Phosphorylation and Wnt Signaling Activation. Mol Cell Biol. 2011 Jul;31(13):2577-90.

8.        Chai G, Ma C, Bao K, Zheng L, Wang X, Sun Z, Salo E, Adell T, Wu W. Complete functional segregation of planarian beta-catenin-1 and -2 in mediating Wnt signaling and cell adhesion. J Biol Chem. 2010 Jul 30;285(31):24120-30.

9.        Wang Y, Fu Y, Gao L, Zhu G, Liang J, Gao C, Huang B, Fenger U, Niehrs C, Chen YG, Wu W. Xenopus skip modulates Wnt/beta-catenin signaling and functions in neural crest induction. J Biol Chem. 2010 Apr 2;285(14):10890-901.

10.     *Davidson G, *Wu W, Shen J, Bilic J, Fenger U, Stannek P, Glinka A, Niehrs C. Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature. 2005 Dec 8;438(7069):867-72. (*equal contribution)

11.     Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W. Rspo2 is a secreted activator of Wnt/β-catenin signalling and is required for Xenopus myogenesis. Dev Cell. 2004 Oct; 7(4): 525-34.

12.     *Mao B, *Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature. 2001 May 17; 411(6835):321-5. (*equal contribution)

● 联系方式:

清华大学生命科学学院,100084, 北京

电话:010-62797127/5,         

E-mail:wwu(at)mail.tsinghua.edu.cn