张荣庆 博士

教授 博导

1982年    苏州医学院        医学学士

1993年   南京农业大学      博士

1995年   中国科学院动物研究所生殖生物学国家重点实验室  博士后

1998年至现在,任清华大学教授

2009年至现在,任清华大学生命科学学院副院长

1996-2004年历任国家“863”计划海洋生物技术主题第1-3届专家组成员。2007年至今担任国家科技部“973”计划第四届农业领域专家咨询组成员。现任清华大学生命科学学院副院长,清华大学海洋生物技术研究所所长,欧洲海洋生物技术学会(ESMB)会员及Marine Biotechnology国际杂志编委。

2016年-至今 浙江清华长三角研究院生物医药研究所 所长

 

● 研究兴趣、领域:

近年来主要从事海洋生物化学与分子生物学、海洋生物矿化的分子机理等方面的研究工作。近年发表在SCI收录的文章70余篇。

● 代表性论文:

 


代表性论文

 [1]Pan C, Fang D., Xu GR, Liang J, Zhang G., Wang, HZ, Xie LP, Zhang RQ. A novel acidic matrix protein, PfN44, stabilizes the magnesium calcite to inhibit the crystallization of aragonite. Journal of Biological Chemistry, 2014, 289(5): 2776-2787.

[2]Su JT, Liang X, Zhou Q, Zhang GY, Wang HZ, Xie LP, Zhang RQ. Structural characterization of amorphous calcium carbonate-binding protein: an insight into the mechanism of amorphous calcium carbonate formation. Biochemical Journal, 2013, 453: 179-186

[3]Liu XJ, Li J, Xiang L, Zhang RQ. The role of matrix proteins in the control of nacreous layer deposition during pearl formation. Proceedings of the Royal Society B: Biological Sciences, 2012, 279(1730): 1000-1007

[4]Fang D, Pan C, Zhang RQ. Novel Basic Protein, PfN23, Functions as key macromolecule during nacre formation. Journal of Biological Chemistry, 2012, 287(19): 15776-85

[5]Kong YW, Jing G, Yan ZG, Li CZ, Gong NP, Zhu FJ, Li DX, Zhang YR, Zheng GL, Wang HZ, Xie LP, Zhang RQ. Cloning and Characterization of Prisilkin-39, a novel matrix protein serving a dual role in the prismatic layer formation from the oyster Pinctada fucata. Journal of Biological Chemistry, 2009, 284: 10841-10854

[6] Yan ZG, Jing G, Gong NP, Li CZ, Zhou YJ, Xie LP, Zhang RQ. N40, a novel nonacidic matrix protein from pearl oyster nacre facilitates nucleation of aragonite in vitro. Biomacromolecules, 2007, 8:3597-3601

[7] Ma ZJ, Huang J, Sun J, Wang GN, Li CZ, Xie LP, Zhang RQ. A novel extrapallial fluid protein controls the morphology of nacre lamellae in the pearl oyster, Pinctada fucata. Journal of Biological Chemistry, 2007, 282(32):23253-23263

[8] Li SG, Liu C, Zhan AB, Xie LP, Zhang RQ. Influencing mechanism of Ocean acidification on byssus performance in the pearl oyster Pinctada fucataEnviron. Sci. Technol. 2017, 51 (13), 7696–7706.

[9] Liu C, Du JZ, Xie LP, Zhang RQ. Direct observation of nacre proteins in the whole calcite by super resolution microscopy reveals diverse occlusion patterns. Cryst. Growth Des. 2017,4:1966?1976.

[10] Yan Y, Yang D, Yang X, Liu C; Xie J, Zheng GL, Xie LP, Zhang RQ. A novel matrix protein, PfY2, functions as a crucial macromolecule during shell formation. Sci Rep. 2017; 7: 6021.

[11] Gao J, Chen Y, Yang Y, Liang J, Xie J, Liu, Li SG, Zheng GL, Xie LP, Zhang RQ. The transcription factor Pf-POU3F4 regulates expression of the matrix protein genes Aspein and Prismalin-14 in pearl oyster (Pinctada fucata). FEBS J, 2016, 283(10):1962-78.

[12] Xie J, Liang J, Sun J, Gao J, Zhang SR, Liu YJ, Xie LP, Zhang RQ. Influence of the Extrapallial Fluid of Pinctada fucata on the Crystallization of Calcium Carbonate and Shell Biomineralization. Cryst. Growth Des. 2016,16:672?680.

[13] Liu C, Xie LP, Zhang RQ. Ca2+ Mediates the Self-Assembly of the Foot Proteins of Pinctada fucata from the Nanoscale to the Microscale. Biomacromolecules, 2016, 17 (10): 3347–3355.

[14] Liu J, Yang D, Liu ST, Li SG, Xu GR, Zheng GL, Xie LP, Zhang RQ. Microarray: a global analysis of biomineralization-related gene expression profiles during larval development in the pearl oyster, Pinctada fucataBMC Genomics, 2015, 16(1): 325.


 

● 联系方式:

电话:+86-10-62772630

传真:+86-10-62772899

E-mail:rqzhang@mail.tsinghua.edu.cn