陈应华 教授

教授,长江特聘教授,国家杰出青年基金获得者

教育经历

1978-1982 就读于武汉大学病毒系,获理学学士学位(病毒学)
1983-1990 就读于德国慕尼黑大学,获博士学位(免疫学)

工作经历

1982-1983 在武汉大学病毒系工作(助教)
1990-1991 在德国慕尼黑大学免疫学研究所工作(研究助理)
1991-1996 在奥地利因斯布鲁克大学工作(课题组长)
1996-至今 在清华大学生物系(2009年改名生命学院)工作(教授)

 

● 研究兴趣、领域:

艾滋病病毒感染机理和预防机理;病毒抑制剂及重组表位疫苗的基础研究

● 代表性论文:

近期发表的代表性论文

1. Chang Zhou, Lu Lu, Suiyi Tan, Shibo Jiang*, Ying-Hua Chen*. HIV-1 gp41 ectodomain induces activation of the CD74-mediated ERK/MAPK pathway to enhance viral infection. Journal of Biological Chemistry 2011.286: 44869-77.

2. Xiaowen Yu, Lu Lu, Lifeng Cai, Pei Tong, Suiyi Tan, Peng Zou, Fanxia Meng, Ying-hua Chen*, and Shibo Jiang*. Mutations of Gln64 in the HIV-1 gp41 N-terminal heptad repeat render viruses resistant to peptide HIV fusion inhibitors targeting gp41 pocket. Journal of Virology. 2012, 86: 589-593.

3. Zhu Y, Lu L, Xu LL, Yang HW, Jiang Shibo*, Chen YH*. Identification of a gp41 Core-binding Molecule with Homologous Sequence of Human TNNI3K Like Protein as a Novel Human Immunodeficiency Viruses Type 1 Entry Inhibitor. Journal of Virology. 2010;84(18):9359-68.

4. Chen X, Lu L, Qi Z, Lu H, Wang J, Yu X, Chen YH*, Shibo Jiang*. Novel recombinant engineered gp41 N-terminal heptad-repeat trimers: potential as anti-HIV-1 therapeutics or microbicides. Journal of Biological Chemstry. 2010;285(33):25506-15.

5. Huang JH, Qi Z, Wu F, Kotula L, Jiang SB*, Chen YH*. Interaction of HIV-1 gp41 core with NPF motif in Epsin - Implication in endocytosis of HIV. Journal of Biological Chemstry 2008;283(22):14994-15002.

6. Lu L, Zhu Y, Huang JH, Chen X, Yang HW, Jiang SB*, Chen YH*. Surface exposure of the HIV-1 Env cytoplasmic tail LLP2 domain during the membrane fusion process - Interaction with gp41 fusion core. Journal of Biological Chemstry.2008;283(24):16723-16731.

7. Huang JH, Lu L, Lu H, Chen X, Jiang S, Chen YH. Identification of the HIV-1 gp41 core-binding motif in the scaffolding domain of caveolin-1. Journal of Biological Chemistry. 2007, 282: 6143–6152.

8. Huang JH, Yang HW, Liu S, Jiang S, Chen YH. The mechanism by which molecules containing the HIV-1 gp41 core-binding motif HXXNPF inhibit HIV-1 envelope glycoprotein-mediated syncytium-formation. Biochemical Journal.2007, 403: 565-571.

9. Yue Tan, Junyi Wang, Shan Su, Qian Wang , Shibo Jiang*, Lu Lu* and Chen YH*. Enhancement of endocytic uptake of HIV-1 virions into CD4-negative epithelial cells by HIV-1 gp41 via its interaction with POB1. Cellular & Molecular Immunology.(2017) 14(6):568-571

10. Tan Y, Tong P, Zhao L, Li J, Wang J*, Chen YH*. The membrane proximal region of CCR5 participates in the cellular entry of HIv-1. Front Immunology (2017), 8:478

 

● 荣誉、奖励及参加学术团体的情况:

1999 获得香港求是科技基金会‘杰出青年学者奖’
2000 获得国家杰出青年基金
2000 被聘为教育部长江学者奖励计划特聘教授
2003 获得教育部自然科学奖一等奖(第一获奖人)

 

● 联系方式:

E-mail: chenyh@tsinghua.edu.cn