Junmin Pan, Ph.D.

Professor in Cell Biology

HeBei Normal University, B.A., 1986

Institute of Hydrobiology, Chinese Academy of Sciences,M.S., 1989

University of Freiburg, Germany, Ph.D., 1996

UT Southwestern Medical Center, Postdoctora, 1997-1999

UT Southwestern Medical Center, Instructor, 1999-2001

UT Southwestern Medical Center, Research Assistant Prof., 2001-2006

Tsinghua University, Professor, 2006 - present

 

Research interest

Cilia and eukaryotic flagella (interchangeable terms) are microtubule-based cellular surface protrusions. They play essential roles in cell motility and signaling to regulate various biological processes including sensory transduction, development, and organ homeostasis. Defects in the structure and/or function of cilia/flagella have been implicated in various human disease and developmental disorders including renal diseases, disease of the respiratory system, male infertility, malformation of skeleton, obesity and etc.

 

The structural integrity and proper function of cilia/flagella requires coordinated regulation of the assembly and disassembly of cilia. In most of our studies, we are using Chlamydomonas, a uni-cellular green alga, as a model organism to study the mechanisms underlying the ciliary assembly, disassembly and ciliary length control. As cilia and eukaryotic flagella are conserved cellular organelles, our research findings have important implications for human development and human ciliary diseases.

 

Selected publications

Zhao Q, Li S, Shao S, Wang Z, Pan, J*. 2020. FLS2 Is a CDK-like Kinase That Directly Binds IFT70 and Is Required for Proper Ciliary Disassembly in Chlamydomonas. Plos Genet. 16(3):e1008561

Wang Y, Ren Y, Pan J*. 2019. Regulation of flagellar assembly and length in Chlamdyomonas by LF4, a MAPK-related kinase. FASEB J. 33(5), 6431-6441.

Liang Y, Zhu X, Wu Q, Pan J*. 2018. Ciliary Length Sensing Regulates IFT Entry via Changes in FLA8/KIF3B Phosphorylation to Control Ciliary Assembly. Curr, Biol. 28(15), 2429-2435.

Zhu B, Zhu X, Wang L, Liang Y, Feng Q, and Pan J*. 2017. Functional exploration of the IFT-A complex in intraflagellar transport and ciliogenesis. PloS Genetics 13, e1006627.

Xu F, Wu X, Jiang L-H, Zhao Hu*, and Pan J*. 2016. An organelle K+ channel is required for osmoregulation in Chlamydomonas reinhardtii. J Cell Sci 129, 3008-14.

Zhangfeng Hu, Yinwen Liang, Wei He and Junmin Pan*. 2015. Cilia disassembly with two distinct phases of regulation. Cell Reports 10, 1803-1810. 

 Yinwen Liang, Yunong Pang, Qiong Wu, Zhangfeng Hu, Xue Han, Yisheng Xu, Haiteng Deng and Junmin Pan*. 2014. FLA8/KIF3B phosphorylation regulates kinesin-II interaction with IFT-B to control IFT entry and turnaround. Dev Cell. 30, 585-597.

Cao M., D. Meng, L. Wang, S. Bei, W.J. Snell*, and Junmin Pan*. 2013. Activation loop phosphorylation of a protein kinase is a molecular marker of organelle size that dynamically reports flagellar length. PNAS, 110, 12337-42. 

Wang L., T. Piao, M. Cao, Q. Tao, L. Huang, H. Deng, T. Mao and Junmin Pan*. 2013. Flagellar regeneration requires cytoplasmic microtubule depolymerization and kinesin13. J. Cell Sci. 126, 1531-1540, covered image and featured article

Luo M, M Cao, Y Kan, G Li, W Snell and Junmin Pan*. 2011. Protein phosphosphorylation states of an auroa-like kinase marks the length of growing flagella. Current Biology,21,586-591. (IF 10.9)

Piao tian, , Minna Luo, Liang Wang, Yan Guo,De Li, Peng Li, William J. Snell,Junmin Pan*. 2009. A microtubule depolymerizing kinesin functions during both flagellar disassembly and flagellar assembly in Chlamydomonas. PNAS, 106, 4713-4718 (direct submission)

 

 

Contact information

School of Life Sciences

Tsinghua University

Haidian district, Beijing 100084

P. R. China

Tel. /Fax: 0086-10-62771864

Email: panjunmin@tsinghua.edu.cn