Yongzhang LUO

Yongzhang Luo Ph.D. Professor, Cheung Kong Scholar Winner of the National Science Foundation for Outstanding Young Scientists of China Director of National Engineering Laboratory for Anti-Tumor Protein Therapeutics Director of Beijing Key Laboratory for Protein Therapeutics

1981-1985, B.S., Chemistry, Lanzhou University

1989-1993, Ph.D., Biochemistry, University of California at Berkeley

1993-1994, Postdoc, Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA

1994-1998, Postdoc, Department of Biochemistry, Stanford University School of Medicine, Stanford, California, USA

Dr. Luo is currently a professor of Tsinghua University


Research interest

1. The molecular mechanisms of tumor angiogenesis, lymphangiogensis

2. Tumor microenvironment and molecular mechanisms of tumor metastasis

3. Cancer early diagnosis

4. Unraveling the mechanisms of aging, cardiovascular diseases, and alzheimer's disease

5. Translational medicine on protein therapeutics & diagnosis


Selected publications

1. Shan Wang, Xin-an Lu, Peng Liu, Yan Fu, Lin Jia, Shunli Zhan & Yongzhang Luo (2015). “Endostatin Has ATPase Activity, Which Mediates Its Antiangiogenic and Antitumor Activities” Molecular cancer therapeutics. 14(5); 1192–201.

2. Hui Wang, Yang Chen, Xin-an Lu, Guanghua Liu, Yan Fu & Yongzhang Luo (2015). “Endostatin Prevents Dietary-Induced Obesity by Inhibiting Adipogenesis and Angiogenesis” Diabetes 64:2442–2456.

3. Jian Yang, Xiaomin Song, Yang Chen, Xin-an Lu, Yan Fu & Yongzhang Luo (2014). “PLCγ1–PKCγ Signaling-Mediated Hsp90α Plasma Membrane Translocation Facilitates Tumor Metastasis” Traffic. 15, 861-878.

4. Xin-an Lu, Xiaofeng Wang, Wei Zhuo, Lin Jia, Yushan Jiang, Yan Fu & Yongzhang Luo (2014). “The regulatory mechanism of a client kinase controlling its own release from Hsp90 chaperone machinery through phosphorylation” Biochem. J. 457, 171–183.

5. Xiaofeng Wang, Xin’an Lu, Xiaomin Song, Wei Zhuo, Lin Jia, Yushan Jiang & Yongzhang Luo (2012). “Thr90 phosphorylation of Hsp90α by protein kinase A regulates its chaperone machinery” Biochem. J. 441, 387-397.

6. Yan Fu & Yongzhang Luo (2010). “The N-terminal integrity is critical for the stability and biological functions of endostatin” Biochemistry 49, 6420–6429.

7. Xiaofeng Wang, Xiaomin Song, Wei Zhuo, Yan Fu, Hubing Shi, Yun Liang, Maomeng Tong, Guodong Chang & Yongzhang Luo (2009). “The regulatory mechanism of Hsp90α secretion and its function in tumor malignancy” Proc. Natl. Acad. Sci. USA 106, 21288-21293.

8. Yujie Huang, Nan Song, Yanping Ding, Shaopeng Yuan, Xuhui Li, Hongchen Cai, Hubing Shi & Yongzhang Luo (2009). “Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis” Cancer Research 69, 7529-7537.

9. Hubing Shi, Yujie Huang, Hao Zhou, Xiaomin Song, Shaopeng Yuan, Yan Fu & Yongzhang Luo (2007). “Nucleolin is a receptor that mediates antiangiogenic and anti-tumor activity of endostatin” Blood (Featured in Cover) 110, 2899-2906. Comment on Shi et al, page 2899, by Judah Folkman (2007). “Endostatin finds a new partner: nucleolin” Blood 110, 2786-2787.

10. Yujie Huang, Hubing Shi, Hao Zhou, Xiaomin Song, Shaopeng Yuan & Yongzhang Luo (2006). “The angiogenesis function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin” Blood 107, 3564-3571.


Contact information




Web: www.luolab.org, www.antitumor.org