Yule Liu, Ph.D.


1994-1997:  Ph. D.  Institute of Microbiology, Chinese Academy of Sciences, Beijing, China and Scottish Crop Research Institute, Dundee, UK
1990-1992:  M. Sc.  Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
1984-1988:  B. Sc.  Department of Biology, NanKai University, Tianjin, China

1988.8-1998.9:    From Research Associate to Full Professor, Institute of Microbiology,
                                Chinese Academy of Sciences, Beijing, China
1995.5-1996.5:    Visiting Scientist, Scottish Crop Research Institute, UK
1998.9-1999.8:    Postdoc., University of Texas at Austin, TX, USA
1999.9-2002.8:    Postdoc., Yale University, USA  
2002.9-2006.12:  Associate Research Scientist, Yale University, USA
2007.1 ---           Professor, Tsinghua University, Beijing,  China


Research interest

  • Signal transduction and regulation of plant immunity

  • Molecular basis of plant viral pathogenesis

  • Plant autophagy

  • Plant functional genomics

Selected publications

1.Yang M, Ismayil A, Liu Y*. Autophagy in plant-virus interactions,Annual Review of Virology2020,doi: 10.1146/annurev-virology-010220-054709

2.Wang J, Chen T, Han M, Qian L, Li J, Wu M, Han T, Cao J, Nagalakshmi U, Rathjen JP, Hong Y, Liu Y*. Plant NLR immune receptor Tm-22 activation requires NB-ARC domain-mediated self-association of CC domain. PLoS Pathogens 16(4):e1008475, 2020

3.Ismayil A, Yang M, Haxima Y, Wang Y, Li J, Han L, Wang Y, Zheng X, Wei X, Nagalakshmi U, Hong Y, Hanley-Bowdoin L, Liu Y*. Cotton leaf curl Multan virus βC1 protein induces autophagy by disrupting the interaction of autophagy related protein 3 with Glyceraldehyde-3 Phosphate Dehydrogenases. Plant Cell 32(4):1124-1135, 2020

4.Ismayil A, Yang M, Liu Y*, Role of autophagy during plant-virus interactions, Seminars in Cell and Developmental Biology, 101: 36-40 2020

5.Zheng X, Wu M, Li X, Cao J, Li J, Wang J, Huang S, Liu Y*, Wang Y*, Actin filaments are dispensable for bulk autophagy in plants, Autophagy,15(12): 2126-2141, 2019

6.Wang Y, Wu Y, Gong Q, Ismayil1 A, Yuan Y, Lian B, Jia Q, Han M, Deng H, Hong Y, Hanley-Bowdoin L, Qi Y*, Liu Y*. Geminiviral V2 Protein Suppresses Transcriptional Gene Silencing through Interaction with AGO4. Journal of Virology 93(6): e01675-18 2019

7.Ismayil A, Haxim Y, Wang Y, Li H, Qian L, Han T, Chen T, Jia Q, Yihao Liu A, Zhu S, Deng H, Gorovits R, Hong Y, Hanley-Bowdoin L, Liu Y*. Cotton Leaf Curl Multan virus C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase. PLoS Pathogens 14(8): e1007282, 2018

8.Yang M, Zhang Y, Xie X, Yue N, Li J, Wang XB, Han CG, Yu JL, Liu Y*, Li D*. Barley Stripe Mosaic Virus γb Protein Subverts Autophagy to Promote Viral Infection by Disrupting the ATG7-ATG8 Interaction. Plant Cell 30(7):1582-1595, 2018

9.Wang S, Xie K, Xu G, Zhou H, Guo Q, Wu J, Liao Z, Liu N, Wang Y, Liu Y*. Plant G proteins interact with ER luminal protein receptors to regulate ER retrieval. J Integr Plant Biol. 60(7):541-561, 2018

10.Haxim Y, Ismayil A, Jia Q, Wang Y, Zheng X, Chen T, Qian L, Liu N, Wang Y, Han S, Cheng J, Qi Y, Hong Y, Liu Y*, Autophagy functions as an antiviral mechanism against geminiviruses in plants. eLife 6, e23897., 2017

11.Xu G, Wang S, Han S, Xie K, Wang Y, Li J, Liu Y*, Plant Bax Inhibitor-1 interacts with ATG6 to regulate autophagy and programmed cell death. Autophagy, 13(7):1161-1175, 2017

12.Chen T, Liu D, Niu X, Wang J, Qian L, Han L, Liu N, Zhao J, Hong Y, Liu Y*, Antiviral resistance protein Tm-22 functions on the plasma membrane. Plant Physiology, 173(4): 2399-2410, 2017

13.Liu N, Xie K, Jia Q, Zhao J, Chen T, Li H, Wei X, Diao X, Hong Y, Liu Y*, Foxtail Mosaic Virus-Induced Gene Silencing in Monocot Plants, Plant Physiology, 171(3):1801-7, 2016

14.Jia Q, Liu N, Xie K, Dai Y, Han S, Zhao X, Qian L, Wang Y, Zhao J, Gorovits R, Xie D, Hong Y and Liu Y*, CLCuMuB βC1 Subverts Ubiquitination by Interacting with NbSKP1s to Enhance Geminivirus Infection in Nicotiana benthamiana, PLoS Pathogens, 12(6): e1005668, 2016

15.Zhao J*, Liu Q, Hu P, Jia Q, Liu N, Yin K, Cheng Y, Yan F, Chen J and Liu Y*, An efficient Potato virus X-based microRNA silencing in Nicotiana benthamiana, Scientific Reports 6: 20573, 2016

16.Wang Y, Zheng X, Yu B, Han S, Guo J, Tang H, Deng H, Hong Y and Liu Y*, Disruption of microtubules in plants suppresses macroautophagy and triggers starchy chloroplast autophagy, Autophagy 11(12): 2259-74, 2015

17.Han S,Wang Y, Zheng X, Jia Q, Zhao J, Bai F,Hong Y and Liu Y*, Cytoplastic glyceraldehyde-3-phosphate dehydrogenases interact with ATG3 to negatively regulate autophagy and immunity in Nicotiana benthamiana, Plant Cell  27(4):1316-31, 2015

18.Yin K, Han T, Liu G. Chen T, Wang Y, Yu A and Liu Y*, A geminivirus-based guide RNA delivery system for CRISPR/Cas9 mediated plant genome editing, Scientific Reports 5:14926, 2015

19.Sha A, Zhao J, Yin K, Tang Y, Wang Y, Wei X, Hong Y, Liu Y*, Virus-based microRNA silencing in plants, Plant Physiology, 164(1):36-47, 2014.

20.Du Y, Zhao J, Chen T, Liu Q, Zhang H, Wang Y, Hong Y, Xiao F, Zhang L, Shen Q and Liu Y*, Type I J-domain NbMIP1 proteins are required for both Tobacco mosaic virus infection and plant innate immunity, PLoS Pathogens, 9(10): e1003659, 2013.

21.Wang Y & Liu Y*,Autophagic degradation of leaf starch in plants, Autophagy, 9(8): 1247-1248, 2013

22.Wang Y, Yu B, Zhao J, Guo J, Li Y, Han S, Huang L, Du Y, Hong Y, Tang D, and Liu Y*,Autophagy Contributes to the Leaf Starch Degradation, Plant Cell, 25(4): 1383-1399, 2013

23.Zhang H, Zhao J, Liu S, Zhang D and Liu Y*, Tm-22 confers different resistance responses against Tobacco mosaic virus dependent on its expression level, Molecular Plant, 6(3): 971-974, 2013

24.Zhao J, Liu Q, Zhang H, Jia Q, Hong Y, Liu Y*, The RuBisCO small subunit is involved in the tobamovirus movement and Tm-22-mediated extreme resistance, Plant Physiology,161(1): 374-83,2013

25.Xu G, Li S, Xie K, Zhang Q, Wang Y, Tang Y, Liu D, Hong Y, He C, Liu Y*, Plant ERD2-like proteins function as ER luminal protein receptors and participate in programmed cell death during innate immunity, Plant Journal, 72(1): 57-69, 2012

26.Cai J, Xie K, Lin L, Qin B, Chen B, Meng J, Liu Y*, Cotton leaf curl Multan virus newly reported to be associated with cotton leaf curl disease in China. Plant Pathology, 59:794-795,2010

27.Tang Y, Wang F, Zhao J, Xie K, Hong Y, Liu Y*, Virus-based microRNA expression for gene functional analysis in plants, Plant Physiology 153 (2): 632-641, 2010

28.Xu G, Sui N, Tang Y, Xie K, Lai Y, Liu Y*, One-step, zero-background ligation independent cloning intron-containing hairpin RNA constructs for RNAi in plants, New Phytologist 187 (1):240–250, 2010

29.Burch-Smith T#, Schiff M#, Liu Y#, and Dinesh-Kumar SP, Efficient virus induced gene silencing in Arabidopsis thaliana, Plant Physiology, 142(1):21-27, 2006 (#co-first author)

30.Liu Y, Schiff M, Czymmek K, Talloczy Z., Levine B and Dinesh-kumar SP. Autophagy regulates programmed cell death during the plant innate immune response, Cell, 121(4), 567-577, 2005

31.Liu Y#, Burch-Smith T#, Schiff M, Feng S, Dinesh-Kumar SP. Molecular chaperone hsp90 associates with resistance protein n and its signaling proteins sgt1 and rar1 to modulate an innate immune response in plants. Journal of Biological Chemistry, 279(3): 2101-8, 2004 (#co-first author)

32.Liu Y, Schiff M, Dinesh-Kumar SP, Functional requirement of A MAPK cascades, WRKY/MYB1 transcription factors, COI1 and CTR1 in N-mediated resistance to Tobacco mosaic virus, Plant Journal, 38(5), 800-809, 2004

33.Liu Y#, Nakayama N#, Schiff M, Litt A, Irish VF and Dinesh-Kumar SP, Virus-induced silencing of a DEFICIENS ortholog in Nicotiana benthamiana, Plant Molecular Biology, 54(5), 701-711, 2004 (#co-first author)

34.Bilgin D#, Liu Y#, Schiff M, Dinesh-Kumar S. P, P58IPK, a plant ortholog of double-stranded RNA-dependent protein kinase PKR inhibitor, functions in viral pathogenesis. Developmental Cell, 4, 651-661, 2003 (# co-first author)

35.Xie Y, Liu Y*, Meng M, Chen L and Zhu Z*, Isolation and identification of a super strong plant promoter from Cotton leaf curl Multan virus, Plant Molecular Biology, 53(1), 1-14, 2003

36.Liu Y, Schiff M, Dinesh-Kumar S. P. Virus-induced gene silencing in Tomato, Plant Journal 31(6), 777-786, 2002

37.Liu Y, Schiff M, Serino G, Deng X-W and Dinesh-Kumar S. P, Role of SCF ubiqutin-ligase and the COP9 signalosome in the N-mediated resistance to tobacco mosaic virus, Plant Cell14(7), 1483-1496, 2002

38.Liu Y, Schiff M, Marathe R. and Dinesh-kumar. Tobacco Rar1, EDS1 and NPR1/NIM1 like genes are required for N-mediated resistance to tobacco mosaic virus. Plant Journal 30(4): 415-29, 2002

39.Liu Y, Robinson DJ, Harrison BD, Defective forms of cotton leaf curl virus DNA-A that have different combinations of sequence deletion, duplication, inversion and rearrangement, Journal of General Virology, 79:1501-8, 1998

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