Maojun YANG, Ph.D.

PHD Professor  

1995-1999  B.S., Jilin University, Changchun, P.R.China

1999-2003  Ph.D., Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, P.R.China

2003-2004  Senior Visiting Scholar, University of Lübeck, Lübeck, Germany

2004-2008  Post-doctoral Fellow ,University of Texas, Southwestern Medical Center, Dallas, TX

2008-present  Professor, School of Life Sciences, Tsinghua University



Research interest

We are mainly interested in the structural and functional studies on sever disease-related proteins, and also covering small molecule screening and structure-based designing of specific inhibitors for these proteins. Recently we have obtained some achievements in understanding the structures and mechanisms of mitochondrial proteins, and protein ubiquitination pathways.



Selected publications

1.    Yang Y, Yu Y, Li X, Li J, Wu Y, Yu J, Ge J, Huang Z, Jiang L*, Rao Y*, Yang M*. Target Elucidation by Co-crystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium Falciparum (PfNDH2) with Small Molecule to Eliminate Drug-Resistant Malaria. J Med Chem. 2017 Mar 9;60(5):1994-2005.

2.    Wu K, Li W, Yu L, Tong W, Feng Y, Ling S, Zhang L, Zheng X*, Yang M*, Tian C*. Temperature-dependent ESR and computational studies on antiferromagnetic electron transfer in the yeast NADH dehydrogenase Ndi1. Phys Chem Chem Phys. 2017 Feb 8;19(6):4849-4854.

3.    Wu M, Gu J, Guo R, Huang Y, Yang M*. Structure of mammalian respiratory supercomplex I1III2IV1Cell. 2016, Dec 1. 2016 Dec 01; 167(6):1598-1609.e10.

4.    Gu J, Wu M, Guo R, Yan K, Lei J, Gao N*, Yang M*. The architecture of the mammalian respirasome. Nature. 2016 Sep 21;537(7622):639-43.

5.    Wang QC, Zheng Q, Tan H, Zhang B, Li X, Yang Y, Yu J, Liu Y, Chai H, Wang X, Sun Z, Wang JQ, Zhu S, Wang F, Yang M, Guo C, Wang H, Zheng Q, Li Y, Chen Q, Zhou A, Tang TS. TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel. Cell. 2016 Jun 2;165(6):1454-66.

6.    Zhang C, Hao H, Yu Y, Kong D, Chen S, Jiang H, Yuan Y, Zheng Y, Yang M*, Jiang Y*. Structural basis of the interaction between the meningitis pathogen Streptococcus suis adhesin Fhb and its human receptor. FEBS Lett.2016 May;590(9):1384-92.

7.    Ge J, Li W, Zhao Q, Li N, Cheng M, Zhi P, Li R, Gao N*, Xiao B*, Yang M*. Architecture of the Mammalian Mechanosensitive Piezo1 Channel. Nature. 2015. Nov 5;527(7576):64-9. (Article)

8.    Li N, Zhai Y, Zhang Y, Li W, Yang M, Lei J, Tye BK, Gao N. Structure of the eukaryotic MCM complex at 3.8 ?. Nature. 2015 Aug 13;524(7564):186-91.

9.    Yu J, Pian Y, Ge J, Guo J, Zheng Y, Jiang H, Hao H, Yuan Y, Jiang Y*, Yang M*. Functional and Structural Characterization of the Antiphagocytic Properties of a Novel Transglutaminase from Streptococcus suis. J Biol Chem.2015 Jul 31;290(31):19081-92.

10.  Yu J, Ge J, Heuveling J, Schneider E*, Yang M*. Structural basis for substrate specificity of an amino acid ABC transporter. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5243-8.

11.  Li Y, Zhang L, Liu T, Chai C, Fang Q, Wu H, Paula Garcia, Han Z, Zong S, Yu Y, Zhang X, Parthun M, Chai J, Xu R and Yang M*. Hat2p recognizes histone H3 tail to specify the acetylation of newly-synthesized H3/H4 heterodimer by Hat1p/Hat2p complex. Genes & Development. 2014 Jun 1;28(11):1217-27.

12.  Li Y, Wu W, Wu H, Zhuo W, Liu W, Zhang Y, Cheng M, Chen Y, Gao N, Yu H, Wang L, Li W and Yang M*. Structural insight into the TRIM family of ubiquitin E3 ligases. Cell Research.2014 Jun;24(6):762-5.

13.  Guo Y, Dong L, Qiu X, Wang Y, Zhang B, Liu H, Yu Y, Zang Y, Yang M, Huang Z. Structural basis for hijacking CBFβ and CUL5 E3 ligase complex by HIV-1 Vif. Nature. 2014 Jan 9;505(7482):229-33.

14.  Yu Y, Zhou M, Kirsch F, Xu C, Zhang L, Wang Y, Jiang Z, Wang N, Li J, Eitinger T, Yang M*. Planar substrate binding site dictates the specificity of ECF-type nickel/cobalt transporters. Cell Research. 2014 Mar;24(3):267-77.

15.  Zhang Y, Zhao H, Wang J, Ge J, Li Y, Gu J, Li P, Feng Y, Yang M*. Structural insight into Caenorhabditis elegans sex-determining protein FEM-2. J Biol Chem. 2013 Jul 26;288(30):22058-66.

16.  Sun Z, Gong J, Wu H, Xu W, Wu L, Xu D, Gao J, Wu JW, Yang H, Yang M, Li P. Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes. Nat Commun. 2013;4:1594.

17.  Feng Y, Li W, Li J, Wang J, Ge J, Xu D, Liu Y, Wu K, Zeng Q, Wu JW, Tian C, Zhou B, Yang M*. Structural insight into the type-II mitochondrial NADH dehydrogenases. Nature. 2012 Nov 15;491(7424):478-82.

18.  Zhang X, Wang J, Feng Y, Ge J, Li W, Sun W, Iscla I, Yu J, Blount P, Li Y*, Yang M*. Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance. Proc Natl Acad Sci U S A.2012 Oct 30;109(44):18180-5.

19.  Xiang H, Feng Y, Wang J, Liu B, Chen Y, Liu L, Deng X*, Yang M*. Crystal structures reveal the multi-ligand binding mechanism of Staphylococcus aureus ClfB. PLoS Pathog. 2012;8(6):e1002751.

20.  She J, Han Z, Kim TW, Wang J, Cheng W, Chang J, Shi S, Wang J, Yang M, Wang ZY, Chai J. Structural insight into brassinosteroid perception by BRI1.Nature. 2011 Jun 12;474(7352):472-6.

21.  Zhang JH, Ge L, Qi W, Zhang L, Miao HH, Li BL, Yang M, Song BL. The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake. J Biol Chem. 2011 Jul 15;286(28):25088-97.

22.  Doyle JM, Gao J, Wang J, Yang M*, Potts PR*. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Mol Cell. 2010 Sep 24;39(6):963-74.

23.  Guo R, Zong S, Wu M, Gu J, Yang M#.Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2. Cell. 2017 Sep 7;170(6):1247-1257.


Contact information