Zhucheng CHEN, Ph.D.


1998      NanKai University, China              B.S.

2001      Peking University, China               M.S.

2003      New York University, USA             M.S.

2008      Cornell University, USA                 Ph.D.

2011      UT Southwestern Medical Center, USA Postdoc


Research interest

Structure, function and regulation of proteins in cell division and cell migration. Major research topics: 1) prokaryotic cytoskeleton 2) Assembly of actin cytoskeleton and its regulation in cancer metastasis 3) Molecular machinery of cytokinesis

Selected publications

1.      Sun L#, Guan R#, Lee IJ, Liu Y, Chen M, Wang J, Wu JQ, Chen Z*. Mechanistic insights into the anchorage of the contractile ring by anillin and Mid1. Dev. Cell. 33(4):413-26, 2015

2.      Xia X#, Liu X#, Li T, Fang, X, Chen Z* . Structure of chromatin remodeller Swi2/Snf2 in the resting state. Nat. Struct. Mol. Biol. 23(8):722-9, 2016

3.      Cao T, Sun L, Jiang Y, Huang S, Wang J, Chen Z*. Crystal structure of a nuclear actin ternary complex. PNAS.113(32): 8985-90, 2016

4.      Xu P#, Li C#, Chen Z, Jiang S, Fan S, Wang J, Dai J, Zhu P*, Chen Z* The NuA4 core complex acetylates nucleosomal histone H4 through a double recognition mechanism. Mol. Cell. 63 (6):965-75, 2016

5.      Yan L#, Wang L#, Tian Y, Xia X, Chen Z*. Structure and regulation of the chromatin remodeller ISWI. Nature 540(7633):466-469, 2016

6.      Guan R#, Zhang L#, Su Q P, Mickolajczyk KJ, Chen GY, Hancock WO,  Sun Y.  Zhao Y, Chen Z* Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin Nature Comm. 8:14951, 2017

7.      Liu X#, Li M#, Xia X#, Li X*, Chen Z* . Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure Nature 544 (7651):440-445, 2017

8.      Li M#, Xia X#, Tian Y#, Jia Q#, Liu X#, Ying L, Li M*, Li X*, Chen Z*. Mechanism of DNA translocation underlying chromatin remodeling by Snf2 Nature, 567(7748): 409-413, 2019.

9.      Yan L#, Wu H#, Li X, Gao N*, Chen Z* Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling Nat. Struct. Mol. Biol. Mar. 13, 2019

10.    Ye Y#, Wu H#, Chen K, Clapier CR, Verma N, Zhang W, Deng H, Cairns BR*, Gao N*, Chen Z*. Structure of the RSC complex bound to the nucleosome. Science, 366(6467):838-843, 2019
11.    Chen M#, Pan H#, Sun L#, Shi P#, Zhang Y, Li L, Huang Y, Chen J, Jiang P, Fang X, Wu C, Chen Z*. Structure and regulation of human epithelial cell transforming 2 protein PNAS 117(2):1027-1035, 2020
12.    Yan L, and Chen Z* A Unifying Mechanism of DNA Translocation Underlying Chromatin Remodeling. Trends Biochem. Sci. 45(3):217-227, 2020


Contact information

Tel: +86-10-62796096
Website: http://cec.life.tsinghua.edu.cn/Lab/Chen_Lab.html
E-mail: zhucheng_chen@mail.tsinghua.edu.cn