Yeguang CHEN, Ph.D.

Ye-Guang Chen, Ph.D; Professor; Cheung Kong Scholar; Recipient of the National Science Foundation for Outstanding Young Scientists of China

1979-1983  Jiangxi University, BSc of Biology

1983-1986  Jiangxi University, MSc of Zoology

1988-1990  Fordham University,MSc of Cell Biology

1991-1996  Albert Einstein College of Medicine,PhD of Cell Biology

1996-2000  Post-doctoral Research Associate, Memorial Sloan-Kettering Cancer Center/Howard Hughes Medical Institute

2000-2002  Assistant Professor, University of California, Riverside

2002-present  Professor, School of Life Sciences, Tsinghua University



Research interest

The molecular mechanism of cell signaling. His research interests concern how TGF-β and Wnt signaling are regulated and aims to understand their roles in embryogenesis, stem cell self-renewal and differentiation and tumorigenesis.


Courses offered

Cell Biology; Topics in Tumor Biology


Selected publications

  1. Qi Z, Li Y, Zhao B, Xu C, Liu Y, Wang X, Yang X, Li B, Han JD, Chen YG#. 2017. BMP restricts the self-renewal of intestinal Lgr5+ stem cells by directly suppressing their signature genes. Nature Communications,8:13824.

  2. Zhao B, Qi Z, Li Y, Wang C, Fu W, Chen YG#. 2015 The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells. Nature Communications, 6:7166.

  3. Zuo W, Huang F, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng XH, Luo S, Gao C, Chen YG#  2013  c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor.  Molecular Cell, 49(3):499-510.

  4. Li Z, Fei1 T, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG#  2012  BMP4 signaling acts via Dual Specificity Phosphatase 9 to control ERK activity in mouse embryonic stem cells. Cell Stem Cell, 10:171-182.

  5. Gao C, Cao W, Bao W, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG#  2010  Autophagy negatively regulates Wnt signaling by promoting Dishevelled degradation. Nature Cell Biology, 12:781-790.

  6. Fei T, Xia K, Li Z, Zhou B, Zhu S, Chen H, Zhang J, Chen Z, Xiao H, Han JD#, Chen YG#  2010  Genome-wide Mapping of Smad Target Genes Reveals the Role of BMP Signaling in Embryonic Stem Cell Fate Determination. Genome Research, 20:36-44.

  7. Zhang W, Jiang Y, Wang Q, Ma X, Xiao Z, Zuo W, Fang X#, Chen YG#  2009  Single molecule imaging reveals transforming growth factor-β-induced type II receptor dimerization. Proc Natl Acad Sci. USA, 106:15679-15683.

  8. Wang Q, Huang Z, Xue H, Jin C, Ju XL, Han JD, Chen YG#  2008  MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood, 111:588-595.

  9. Ma J, Wang Q, Fei T, Han JD, Chen YG#  2007  MCP-1 mediates TGF-β-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood, 109:987-994.

  10. Zhang S, Fei T, Zhang L, Zhang R, Chen F, Ning Y, Han Y, Feng XH, Meng A, Chen YG#  2007  Smad7 antagonizes TGF-β signaling in the nucleus by interfering with functional Smad-DNA complex formation.  Molecular and Cellular Biology, 27:4488-4499.

  11. Zhang L, Zhou H, Su Y, Sun S, Zhang H, Zhang L, Zhang Y, Ning Y, Chen YG#, Meng A# 2004 Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science, 306:114-117

  12. 陈晔光、张传茂、陈佺 主编,《分子细胞生物学》(第二版),清华大学出版社,2011年9月出版。



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