Chen DONG

Professor

Education

1997-2000

Postdoctoral   Fellow, Section of Immunobiology, Howard Hughes Medical Institute, Yale   University School of Medicine, New Haven, CT.

1990-1996

Ph.D,   Department of Microbiology, Howard Hughes Medical Institute, University of   Alabama at Birmingham.

1985-1989

Bachelor   in Cell Biology, Wuhan University, Wuhan, China


Positions

February,2017-present

Director,   Beijing Key Lab on Immunological Studies on Chronic Diseases

September,2016-present  

Dean,   School of Medicine, Tsinghua University, Beijing, China

January,2016-Septermber,2016

Executive   Vice Dean, School of Medicine, Tsinghua University, Beijing, China

2015-present     

Vice   Director (Tsinghua), Peking University-Tsinghua University Center for Life   Sciences, Beijing, China

2014-Present

Director,   Institute for Immunology, Tsinghua University, Beijing, China

2013-2016     

Vice   Dean, School of Medicine, Tsinghua University

2008-2013

Director,   Center for Inflammation and Cancer, MD Anderson Cancer Center

2013-present

Professor   (tenured), Tsinghua University, Beijing, China

2010-2013

Olga   Keith and Harry Carothers Wiess Distinguished University Chair in Cancer   Research, MD Anderson Cancer Center

2008-2013

Professor   (tenured), Department of Immunology, University of Texas MD Anderson Cancer   Center

2004-2008

Associate   Professor (tenured), Department of Immunology University of Texas MD Anderson   Cancer Center

2000-2004

Assistant   Professor,    Department of Immunology   University of Washington School of Medicine

 

Research interest

Immunology and Inflammation

We are interested in studying the cellular and molecular mechanisms underlying immune tolerance and immune responses and hope that our research will lead to new approaches of modulating the immune system in a variety of immune diseases and cancers.

1. T lymphocyte differentiation and function
2. Cytokine function and signaling in inflammation
3. Immune tolerance and tumor immunity.

 

Selected publications

1.      Xu, M., Lu, H., Wu, Y., Liu, K., Shi, Y., An, H., Zhang, J., Wang, X., Lai, Y. and Dong, C. An IL-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation. (2018) Immunity. 48(4):787-7982.

2.      Jing Li, Younghee, Lee, Yanjian Li, Yu Jiang, Huiping Lu, Wenjuan Zang, Xiaohong Zhao, Liguo Liu, Yang Chen, Haidong Tan, Zhiying Yang, Michael Q. Zhang, Tak W. Mak, Ling Ni and Chen Dong. Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells. (2018) Immunity. 48(4):773-7863.

3.      Jiang, Y., Liu, Y., Lu, H., Sun, S.-C., Jin, W., Wang, X. and Dong, C. Epigenetic activation during T helper 17 (Th17) cell differentiation is mediated by Tripartite motif containing 28. (2018) Nature Communications. 9:1424

4.      Weiwei Fu, Xindong Liu, Xiang Lin, Han Feng, Lin Sun, Shuran Li, Hairong Chen, Hong Tang, Liwei Lu, Wei Jin, Chen Dong. Deficiency in T follicular regulatory cells promotes autoimmunity. (2018) Journal of Experimental Medicine. 215:815-825

5.      Tao Xu(#), Kelly M. Stewart(#), Xiaohu Wang(#), Kai Liu, Min Xie, Jae Kyu Ryu, Ke Li, Tianhua Ma, Haixia Wang, Lu Ni; Saiyong Zhu, Nan Cao, Dongwei Zhu, Yu Zhang, Katerina Akassoglou, Chen Dong(*), Edward M. Driggers(*), Sheng Ding(*). Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism. (2017) Nature. 548:228-233. (* co-correspondent authors)

6.      Xiao Ding,Aibo Wang,Xiaopeng Ma,Maud Demarque,Jin Wei,Huawei Xin, Anne De jean,Chen Dong. Protein SUMOylation is required for regulatory T cell expansion and function. (2016) Cell Reports. 16:1055-1066.

7.      Xindong Liu, Huiping Lu, Tingting Chen, Kalyan C Nallaparaju, Xiaowei Yan, Shinya Tanaka,  Kenji Ichiyama, Xia Zhang, Li Zhang, Xiaofeng Wen, Qiang, Tian, Xiu-Wu Bian, Wei Jin,  Lai Wei, Chen Dong. Genome-wide analysis identifies Bcl6-controlled regulatory networks during T follicular helper (Tfh) cell differentiation. (2016) Cell Reports. 14:1735-1747

8.      Xindong Liu, Xin Chen, Bo Zhong, Aibo Wang, Xiaohu Wang, Fuliang Chu, Roza I Nurieva, Xiaowei Yan, Ping Chen, Laurens G van der Flier, Hiroko Nakatsukasa, Sattva S Neelapu, Wanjun Chen, Hans Clevers, Qiang Tian, Hai Qi, Lai Wei, Chen Dong. Transcription factor Achaete-Scute homologue 2 initiates T follicular helper cell development. (2014) Nature. 507: 513–518

 

Awards

2017             Highly Cited Researcher, Clarivate Analytics

2016             Highly Cited Researcher, Thomson Reuters

2016             Keynote speaker, 2016 Keystone Symposium on T Follicular Helper Cells and Germinal Centers

2015             Highly Cited Researcher, Thomson Reuters

2014             Highly Cited Researcher, Thomson Reuters

2013             Bayer Chair Professor, Tsinghua University

2013             Faculty Achievement Award in Basic Research, MD Anderson Cancer Center

2012             National Talent Recruitment (Qian Ren) Program awardee

2011             Fellow, American Association for the Advancement of Science

2009             American Association of Immunologists-BD Biosciences Investigator Award

2008-2013    Leukemia and Lymphoma Society Scholar Award

2007-2010    American Lung Association Career Investigator Award

2004             Milstein Young Investigator award, International Society of Interferon and Cytokine Research

2003-2009    Cancer Research Institute Investigator Award

2002              Young Investigator Award (1st Prize), International Cytokine Society

2000 –2005   Arthritis Investigator Award, Arthritis Foundation

 

Contact information

Email: chendong at tsinghua.edu.cn

Phone: +86-10-62798095