XIAOFENG FANG, PH.D.

Principal Investigator

 

2005-2009:    B.S.A. Northwestern A&F University, Xi’an
2009-2015:    Ph.D.,  Peking Union Medical College & National Institute of Biological Sciences (NIBS)
2015-2017:    Postdoctoral Scientist, Tsinghua University,Beijing
2017-2020:    Marie Skłodowska-Curie Fellow, Postdoctoral Scientist, John Innes Centre, UK
2020-present:    Assistant Professor, Principal Investigator, School of Life Sciences, Tsinghua University, Beijing  

 

Research interest

 

We are interested in the mechanisms underlying the assembly and the biological functions of RNA-protein granules during plant development and stress responses. We are also dedicated to investigate the role of RNA 3’ processing during plant development.

Selected publications

 

Fang X*, Wu Z, Raitskin O, Webb K, Voigt P, Lu T, Howard M, Dean C (2020) The 3' processing of antisense RNAs physically links to chromatin-based transcriptional control. PNAS. 117(26):15316-15321. (*co-corresponding author).

Yang M#, Woolfenden HC#, Zhang Y#, Fang X#, Liu Q, Vigh ML, Cheema J, Yang X, Norris M, Yu S, Carbonell A, Brodersen P, Wang J, & Ding Y (2020) Intact RNA structurome reveals mRNA structure-mediated regulation of miRNA cleavage in vivo. Nucleic Acids Res. gkaa577. (#co-first author)

Wu Z, Fang X, Zhu D, Dean C (2020) Autonomous pathway: FLOWERING LOCUS C repression through an antisense-mediated chromatin-silencing mechanism. Plant Physiol. 182(1):27-37.

Bloomer RH, Hutchison CE, Bäurle I, Walker J, Fang X, Perera P, Velanis CN, Gümüs S, Spanos C, Rappsilber J, Feng X, Goodrich J, Dean C (2020) The Arabidopsis epigenetic regulator ICU11 as an accessory protein of Polycomb Repressive Complex 2. PNAS. 117(28):16660-16666.

Fang X#, Wang L#, Ishikawa R#, Li Y, Fiedler M, Liu F, Calder G, Rowan B, Weigel D, Li P, Dean C. (2019) Arabidopsis FLL2 promotes liquid-liquid phase separation of polyadenylation complexes. Nature. 569(7755): 265-269 (#co-first author)

Fang X#, Zhao G#, Zhang S, Li Y, Gu H, Li Y, Zhao Q, Qi Y (2018) Chloroplast-to-nucleus signaling regulates microRNA biogenesis in Arabidopsis. Developmental Cell. 48, 371-382. (#co-first author)

Li Y#, Yuan Y#, Fang X#, Lu X, Lian B, Zhao G, Qi Y (2018) A role for MINIYO and QUATRE-QUART2 in the assembly of RNA polymerases II, IV, and V in Arabidopsis. Plant Cell. 30, 466-480. (#co-first author)

Cui Y#, Fang X#, and Qi Y (2016) TRANSPORTIN1 promotes the association of microRNAs with ARGONAUTE1 in Arabidopsis. Plant Cell. 28, 2576-2585. (#co-first author)

Fang X#, and Qi Y (2016) RNAi in plants: an Argonaute-centered view. Plant Cell. 28, 272-285.

Fang X#,Cui Y, Li Y, and Qi Y (2015) Transcription and processing of primary microRNAs are coupled by Elongator complex in Arabidopsis. Nature Plants. 1, 15075. (Highlighted in the same issue of Nature Plants).

Fang X#,Shi Y#, Lu X, Chen Z, Qi Y (2015) CMA33/XCT regulates small RNA production through modulating the transcription of Dicer-Like genes in Arabidopsis. Molecular Plant. 8, 1227-1236. (#co-first author)

Contact information

 

Address: 4-214 Biotech Building
Email: xffangATmail.tsinghua.edu.cn