Wei XIONG, Ph.D.

Principal Investigator

1999      B.S. in Microbiology School of Life Sciences, Wuhan University

2006      Ph.D. in Neuroscience      Institute of Neuroscience, Chinese Academy of Sciences


2006-2007    Research Associate    Institute of Molecular Medicine, Peking University

2007-2014    Postdoc/Staff Scientist     The Scripps Research Institute

2015-            Principal Investigator       School of Life Sciences, Tsinghua University


Research interest

Biological basis of audition and pathological mechanisms of hearing impairment and deafness.

Selected publications

  1. Chen, J.#, Zhang, X.#, Li, J., Song, C., Jia, Y.*, and Xiong, W.* (2016). Identification of a Novel ENU-Induced Mutation in Mouse Tbx1 Linked to Human DiGeorge Syndrome. Neural Plast 2016, 5836143.

  2. Beurg, M., Xiong, W., Zhao, B., Muller, U., and Fettiplace, R. (2015). Subunit determination of the conductance of hair-cell mechanotransducer channels. Proc Natl Acad Sci U S A 112, 1589-1594.

  3. Xiong, W.*, T. Wagner, L. Yan, N. Grillet, and U. Muller.* "Using Injectoporation to Deliver Genes to Mechanosensory Hair Cells." Nat Protoc 9, no. 10 (2014): 2438-49.

  4. Shang, S., C. Wang, B. Liu, Q. Wu, Q. Zhang, W. Liu, L. Zheng, H. Xu, X. Kang, X. Zhang, Y. Wang, H. Zheng, S. Wang, W. Xiong*, T. Liu*, and Z. Zhou*. "Extracellular Ca(2)(+) Per Se Inhibits Quantal Size of Catecholamine Release in Adrenal Slice Chromaffin Cells." Cell Calcium56, no. 3 (2014): 202-7.

  5. Zheng, L., Wang, C., Shang, S., Zhang, X., Wang, Y., Wu, Q., Hu, M., Chai, Z., Wu, X., Zheng, H., Zhang, C., Wang, L.*, Xiong, W. *, and Zhou, Z. * “Real-time endocytosis imaging as a rapid assay of ligand-GPCR binding in single cells,” Am J Physiol Cell Physiol 305, no. 7 (2013): p. 751-60.

  6. Xiong, W., Grillet, N., Elledge, H. M., Wagner, T. F.J., Zhao, B., Johnson, K. R., Kazmierczak, P. and Müller, U., “TMHS is an Integral Component of the Mechanotransduction Machinery of Cochlear Hair Cells,” Cell 151, no. 6 (2012): p. 1283-95. (Reviewed by Faculty of 1000[F1000Prime.com/717967202])

  7. Xiong, W.#, Liu, T.#, Wang, Y., Chen, X., Sun, L., Guo, N., Zheng, H., Zheng, L., Ruat, M., Han, W., Zhang, C. X. and Zhou, Z., "An Inhibitory Effect of Extracellular Ca on Ca-Dependent Exocytosis," PLoS One 6, no. 10 (2011): e24573.

  8. Grillet, N.#, Xiong, W.#, Reynolds, A.#, Kazmierczak, P., Sato, T., Lillo, C., Dumont, R. A., Hintermann, E., Sczaniecka, A., Schwander, M., Williams, D., Kachar, B., Gillespie, P. G. and Müller, U., "Harmonin Mutations Cause Mechanotransduction Defects in Cochlear Hair Cells," Neuron 62, no. 3 (2009): 375-387. Featured in Neuron Previews in the same issue)

  9. Schwander, M., Xiong, W., Tokita, J., Lelli, A., Elledge, H. M., Kazmierczak, P., Sczaniecka, A., Kolatkar, A., Wiltshire, T., Kuhn, P., Holt, J. R., Kachar, B., Tarantino, L. and Müller, U., "A Mouse Model for Nonsyndromic Deafness (Dfnb12) Links Hearing Loss to Defects in Tip Links of Mechanosensory Hair Cells," Proc Natl Acad Sci U S A 106, no. 13 (2009): 5252-5257. (Featured in Proc Natl Acad Sci U S A Commentaryin the same issue)

 (#, Co-first Author; *, Co-correspondence Author)


Contact information

Add.: Room B216, Medical Science Building,School of Life Sciences, Tsinghua University

Tel: +86-10-62792464

Email: wei_xiong@mail.tsinghua.edu.cn

Website: http://www.neurocomlab.org/