Jun YAO, Ph. D.

Principal Investigator

1999     B. S.,  Nanjing University, China

2001     M.S.,   Nanjing University, China

2007     Ph.D., The Pennsylvania State University, USA


2007-2011     Postdoctoral Research Associate, Howard Hughes Medical Institute, University of Wisconsin, USA

2011-2013     Research Associate, Laboratory of Genetics, The Salk Institute for Biological Studies, USA

2013-            Principal Investigator, School of Life Sciences, Tsinghua University, China


Research interest

1. Pathogenesis of neuropsychiatric disorders using induced pluripotent stem cell technology

2. Electrophysiological and optogenetic study of neuropsychiatric disorders based on mouse models

3. Synaptic dysfunctions in neuropsychiatric disorders


Selected publications

  1. Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames TJ, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, ?degaard KJ, McCarthy MJ, Zandi PP, PBDS, Mi S, Brennand KJ, Kelsoe JR, Gage FH, Yao J (2015). Differential Responses to Lithium in Hyperexcitable Neurons from Bipolar Patients. Nature. 2015 Nov 5;527(7576):95-9. doi: 10.1038/nature15526.

  2. Yu DX, Di Giorgio DP, Yao J, Marchetto MC, Brennand K, Wright R, Mei A, McHenry L, Lisuk D, Grasmik J, Silberman P, Silberman G, Jappelli R, Gage FH (2014). Modeling hippocampal neurogenesis using human pluripotent stem cells. Stem Cell Reports. 2014 Feb 27;2(3):295-310. doi: 10.1016/j.stemcr.2014.01.009. eCollection 2014 Mar 11.

  3. Yao J, Kwon SE, Gaffaney JD, Dunning FM, Chapman ER (2012). Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles. Nature Neuroscience. 15(2): 243-249.
  4. Yao J, Gaffaney JD, Kwon SE, Chapman ER (2011). Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release. Cell. 147(3):666-77.
  5. Yao J, Mu Y, Gage FH (2012). Neural stem cells: mechanisms and modeling. Protein & Cell. 3(4): 251-261. (Review)
  6. Wu Y, Gu Y, Morphew MK, Yao J, Yeh FL, Dong M, Chapman ER (2012). All three components of the neuronal SNARE complex contribute to secretory vesicle docking in PC12 cells. Journal of Cell Biology. 198(3):323-30. 
  7. Yeh FL, Dong M, Yao J, Tepp WH, Lin G, Johnson EA, Chapman ER (2010). SV2 mediates entry of tetanus neurotoxin into central neurons. PLoS Pathogens. 6(11): e1001207.
  8. Yuan X, Yao J, Norris D, Tran DD, Bram RJ, Chen G, Luscher B (2008). Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors. Molecular and Cellular Neuroscience. 38(2):277-289.
  9. Deng, L.*, Yao, J.*, Fang, C., Dong, N., Luscher, B., Chen G (2007). Sequential postsynaptic maturation governs the temporal order of GABAergic and glutamatergic synaptogenesis in rat embryonic cultures. Journal of Neuroscience. 27(40):10860-9. (*Equal contribution)
  10. Yao, J., Qi, J. S., and Chen, G (2006). Actin-dependent activation of presynaptic silent synapses contributes to long-term synaptic plasticity in developing hippocampal neurons. Journal of Neuroscience. 26(31):8137-47.
  11. Qi, J., Yao, J., Fang, C., Luscher, B., and Chen G (2006). Downregulation of Tonic GABA Currents Following Epileptogenic Stimulation of Rat Hippocampal Cultures. Journal of Physiology. 577(2): 579-590.
  12. Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage FH, Mi S, Yao J (2018). CRISPR interference-based specific and efficient gene inactivation in the brain. Nat Neurosci. 2018 Feb 5. doi: 10.1038/s41593-018-0077-5. [Epub ahead of print]
  13. Liu YN, Lu SY, Yao J. Application of induced pluripotent stem cells to understand neurobiological basis of bipolar disorder and schizophrenia. Psychiatry Clin Neurosci. 2017 Sep;71(9):579-599. doi: 10.1111/pcn.12528. Epub 2017 May 2. (Review)


Contact information

Tel:+86-10-62797147; Email: jyao@mail.tsinghua.edu.cn

Lab website: http://yaolab.life.tsinghua.edu.cn