Yi ZHONG, Ph.D.
Professor, School of Life Sciences, Tsinghua University Director, McGovern Institute for Brain Research,Distinguished Professor of Cheung Kong Scholars
1985-1991 PhD., Department of Biology, University of Iowa, Iowa City, IA, USA.
1982-1984 M.S., Department of Biotechnology and Biological Science, Tsinghua University, Beijing, China.
1978-1982 B.S., Department of Engineering Physics, Tsinghua University, Beijing, China.
2015-present Professor, School of Life Sciences, Tsinghua University, Beijing, China.
2001-2015 Chair Professor, School of Life Sciences, Tsinghua University, Beijing, China.
2004-2015 Professor, Cold Spring Harbor Lab. Cold Spring Harbor. USA.
1998-2004 Associate Professor, Cold Spring Harbor Lab. Cold Spring Harbor. USA.
1995-1998 Senior Staff Investigator, Cold Spring Harbor Lab. Cold Spring Harbor. USA.
1992-1995 Staff Investigator, Cold Spring Harbor Lab. Cold Spring Harbor, USA.
We study neural mechanism of learning and memory using genetics, electrophysiology, behavior and imaging. We firstly reveal the molecular mechanism of active forgetting and will further explore related researches. We also study human memory-related diseases, such as Alzheimer's disease, Autism, and Schizophrenia, and make efforts to develop potential drugs.
1. Liu Y, Du S, Lv L, Lei B, Shi W, Tang Y, Wang L, and Zhong Y*. Hippocampal Activation of Rac1 Regulates the Forgetting of Object Recognition Memory. Current Biology, 2016, 26, 2351-2357.
2. Zhang X, Li Q, Wang L, Liu ZJ, and Zhong Y*. Cdc42-Dependent Forgetting Regulates Repetition Effect in Prolonging Memory Retention. Cell Reports, 2016, 16, 817-825.
3. Dong T, He J, Wang S, Wang L, Cheng Y, and Zhong Y*. Inability to activate Rac1-dependent forgetting contributes to behavioral inflexibility in mutants of multiple autism-risk genes. Proc Natl Acad Sci U S A, 2016, 113, 7644-7649.
4. Li Q, Zhang X, Hu W, Liang X, Zhang F, Wang L, Liu ZJ, and Zhong Y*. Importin-7 mediates memory consolidation through regulation of nuclear translocation of training-activated MAPK in Drosophila. Proc Natl Acad Sci U S A, 2016, 113, 3072-3077.
5. Wang L, Chiang HC, Wu W, Liang B, Xie Z, Yao X, Ma W, Du S, and Zhong Y*. Epidermal growth factor receptor is a preferred target for treating amyloid-beta-induced memory loss. Proc Natl Acad Sci U S A, 2012, 109, 16743-16748.
6. Huang C, Zheng X, Zhao H, Li M, Wang P, Xie Z, Wang L, and Zhong Y*. A permissive role of mushroom body alpha/beta core neurons in long-term memory consolidation in Drosophila. Current Biology, 2012, 22, 1981-1989.
7. Shuai Y, Hu Y, Qin H, Campbell RA, and Zhong Y*. Distinct molecular underpinnings of Drosophila olfactory trace conditioning. Proc Natl Acad Sci U S A, 2011, 108, 20201-20206.
8. Shao L, Shuai Y, Wang J, Feng S, Lu B, Li Z, Zhao Y, Wang L, and Zhong Y*. Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila. Proc Natl Acad Sci U S A, 2011, 108, 18831-18836.
9. Shuai YC, Lu BY, Hu Y, Wang LZ, Sun K, and Zhong Y*. Forgetting Is Regulated through Rac Activity in Drosophila. Cell, 2010, 140, 579-589.
10. Pagani MR, Oishi K, Gelb BD, and Zhong Y*. The Phosphatase SHP2 Regulates the Spacing Effect for Long-Term Memory Induction. Cell, 2009, 139, 186-198.
11. Davis, R. L., and Zhong, Y. (2017). The Biology of Forgetting-A Perspective. Neuron 95, 490-503.
12. Shao, L., Lu, B., Wen, Z., Teng, S., Wang, L., Zhao, Y., Wang, L., Ishizuka, K., Xu, X., Sawa, A., Song, H., Ming, G., and Zhong, Y. (2017). Disrupted-in-Schizophrenia-1 (DISC1) protein disturbs neural function in multiple disease-risk pathways. Hum Mol Genet 26, 2634-2648.