Haiteng DENG, Ph.D.


1996    Ph.D. degree, Department of Chemistry, Pennsylvania State University

1988    M.S. degree, Department of Chemistry, Wuhan University

1985    B.S. degree, Department of Chemistry, Wuhan University


5/1996-12/1997 Postdoctoral Fellow, Univ. of Alberta

1/1998-12/1999 Postdoctoral Associate, Oak Ridge National Laboratory

12/1999-12/2001 Instructor, Dept. of Developmental & Molecular Biology, Albert Einstein College of Medicine

12/2001-7/2003 Assistant Professor, Dept. of Medicine, Albert Einstein College of Medicine

8/2003-12/2003 Assistant Professor, University of Nebraska

1/2004-9/2009 Research Assistant Professor, Rockefeller University

9/2009-2/2011 Research Associate Professor and Director of Proteomics Resource Center, Rockefeller University

9/2008-Present Adjunct Faculty, New York University

3/2011-Present Adjunct Professor, Rockefeller University

3/2011-Professor, Tsinghua University, China


Research interest

Development of new techniques in proteomics, metabolomics, and chemical biology; Investigation of immune cell differentiation and function; Discovery of biomarkers for early diagnosis of cancer.

Selected publications

  1. Liu, Z. L.; Hu, Y. D.; Wang, H. L.; Liu, C. D.; Wang, Q. T.; Deng, H. T.* Hydrogen peroxide mediated mitochondrial UNG1-PRDX3 interaction and UNG1 degradation. Free Radic Biol Med 2016, 99, 54-62.

  2. Gong, Y.; Zhang, L.; Li, J.; Feng, S.; Deng, H.* Development of the Double Cyclic Peptide Ligand for Antibody Purification and Protein Detection. Bioconjug Chem 2016, 27 (7), 1569-73.

  3. Tang, H.; Chen, Y.; Liu, X.; Wang, S.; Lv, Y.; Wu, D.; Wang, Q.; Luo, M.; Deng, H.* Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma. Oncotarget 2016 Jun 21;7(25):38822-38834.

  4. Huo, Y.; Zheng, Z.; Chen, Y.; Wang, Q.; Zhang, Z.; Deng, H.* Downregulation of vimentin expression increased drug resistance in ovarian cancer cells. Oncotarget 2016. Jul 19;7(29):45876-45888.

  5. He, L.; Nair, M. K.; Chen, Y.; Liu, X.; Zhang, M.; Hazlett, K. R.; Deng, H.*; Zhang, J. R. The Protease Locus of Francisella tularensis LVS Is Required for Stress Tolerance and Infection in the Mammalian Host. Infect Immun2016, 84 (5), 1387-402.

  6. Liu, Z.; Hu, Y.; Liang, H.; Sun, Z.; Feng, S.; Deng, H.* Silencing PRDX3 Inhibits Growth and Promotes Invasion and Extracellular Matrix Degradation in Hepatocellular Carcinoma Cells. J Proteome Res 2016, 15 (5), 1506-14.

  7. Jiang, X.; Feng, S.; Chen, Y.; Feng, Y.; Deng, H.* Proteomic analysis of mTOR inhibition-mediated phosphorylation changes in ribosomal proteins and eukaryotic translation initiation factors. Protein Cell 2016, 7 (7), 533-7.

  8. Tang, H.; Li, J.; Liu, X.; Wang, G.; Luo, M.; Deng, H.* Down-regulation of HSP60 Suppresses the Proliferation of Glioblastoma Cells via the ROS/AMPK/mTOR Pathway. Sci Rep 2016, 6, 28388.

  9. Tang, H.; Wang, X.; Xu, L.; Ran, X.; Li, X.; Chen, L.; Zhao, X.; Deng, H.*; Liu, X. Establishment of local searching methods for orbitrap-based high throughput metabolomics analysis. Talanta 2016, 156-157, 163-71.

  10. Wang, X.; Tang, H.; Chen, Y.; Chi, B.; Wang, S.; Lv, Y.; Wu, D.; Ge, R.; Deng, H.* Overexpression of SIRT3 disrupts mitochondrial proteostasis and cell cycle progression. Protein Cell 2016, 7 (4), 295-9.

  11. Hong Qu, Yuling Chen, Haiteng Deng*, Zhenyu Zhang, Identification and Validation of Differentially Expressed Proteins in Epithelial Ovarian Cancers Using Quantitative Proteomics, Oncotarget, 2016 Dec 13;7(50):83187-83199.

  12. Gu L, Chen Y, Wang QT, Li X, Mi K, Deng H. *, Functional Characterization of Sirtuin-like Protein in Mycobacterium smegmatis. J Proteome Res. 2015;14(11):4441-9.

  13. Feng S, Chen Y, Yang F, Zhang L, Gong Y, Adilijiang G, Gao Y, Deng H*. Development of a Clickable Probe for Profiling of Protein Glutathionylation in the Central Cellular Metabolism of E. coli and Drosophila. Cell Chem Biol. 2015 Nov 19;22(11):1461-9.

  14. Lixu Jin, Zhiguo Zheng, Xiaoyong Jiang, Yi Huo, Haiyun Deng, Yuling Chen, Qingquan Lian, Renshan Ge, Haiteng Deng*, Down-regulation of Rab 5C-dependent Endocytosis and Glycolysis in Cisplatin-resistant Ovarian Cancer Cell Lines, Molecular and Cellular Proteomics, 2014, Nov;13(11):3138-51.

  15. Yadong Hu, Helin Wang, Renhua Xu, Qingtao Wang, Haiteng Deng*, NAD-Mediated Protein Expression, Cell Proliferation, and Responses to Oxidative Stress, Journal of Proteome Research, 2014 Feb 7; 13(2):786-95.     

  16. Shan Feng, Lei Zhang, Gulishana Adilijiang, Jieyuan Liu, Haiteng Deng*, Substrate Profiling of Glutathione S-transferase with Engineered Enzymes and Matched Glutathione Analogues, Angew Chem Int Ed Engl. 2014 Jul 7;53(28):7149-53.

  17. Weixuan Wang, Yadong Hu, Xiaofei Wang, Qingtao Wang, Haiteng Deng, ROS-mediated 15-Hydroxyprostaglandin Dehydrogenase Degradation via Cysteine Oxidation Promotes NAD+-Mediated Epithelial-Mesenchymal Transition, Cell Chemical Biology, 25, 1–7, March 15, 2018.

  18. Fan Yang, Meiqi Yi, Yan Liu, Qingtao Wang, Yadong Hu, Haiting Deng, Glutaredoxin-1 silencing induces cell senescence via p53/p21/p16 signaling axis, Journal of Proteome Research. J Proteome Res. 2018 Jan 30. doi: 10.1021/acs.jproteome.7b00761. [Epub ahead of print] PMID: 29356545.      


Chapters of Books:

J-R Zhang, MG Marinus, H Deng, Methylation and other Modifications of Nucleic Acids and Proteins, Reference Module in Biomedical Sciences, 2015 Elsevier Inc.

Amanda Chen, Haiqiang Yu, Haiteng Deng and W. Beau Mitchell, Mechanisms of αIIbβ3 Biogenesis in the Megakaryocyte: A Proteomics Approach in Hematology - Science and Practice, Edited by Charles H. Lawrie, ISBN 978-953-51-0174-1, Publisher: InTech, March 02, 2012 DOI: 10.5772/2259.

Haiteng Deng, Proteomics in Drug Discovery in Handbook of Drug Screening, R. Seethala, Eds, Informa Healthcare, May 2009.

Denis L. Rousseau, David Li, Eric Y. Hayden, Haiteng Deng and Syun-Ru Yeh, Protein-ligand interactions in mammalian nitric oxide synthase, in THE SMALLEST BIOMOLECULES: DIATOMICS AND THEIR INTERACTIONS WITH HEME PROTEINS, Abhik Ghosh, Eds, Elsevier, Dec 2007.


Contact information

Add.: School of Life Sciences, Tsinghua University, Haidian District, Beijing, China (100084)

Tel: 010-62789415

E-mail: dht@mail.tsinghua.edu.cn