Zhi LU, Ph.D.

Associate Professor


2017-present Bioinformatics and Genomics ,Tenured PI ,Tsinghua University, Beijing, China
2011-2016  Bioinformatics and Genomics ,PI ,Tsinghua University, Beijing, China
2008-2011  Bioinformatics ,Postdoc ,Yale University, New Haven, CT, US
2003-2008  Biophysics Ph.D.  University of Rochester, Rochester, NY, US
1998-2003  Life Sciences  B.S. University of Science and Technology of China

Research interest


Our group is interested in developing bioinformatics technologies and practicing evidence-based medicine. “Our mission is to detect cancer early, when it can be cured.” 
We utilize high-throughput sequencing technologies, together with machine learning and AI, to understand how genetic information is encoded in the structured DNA and RNA sequences, and how they interact and regulate each other in a biological system. Ultimately, this will help us understand and cure human diseases; know and improve ourselves.
The research in our lab include three directions:
1. RNA Regulation;
2. Precision Medicine;
3. Machine Learning and AI.

Selected publications


 ? Shuaishuai Teng1, Yang Eric Li1, Ming Yang, Rui Qi, Yiming Huang, Qianyu Wang, Yanmei Zhang, Shanwen Chen, Shasha Li, Kequan Lin, Yang Cao, Qunsheng Ji, Qingyang Gu, Yujing Cheng, Zai Chang, Wei Guo, Pengyuan Wang, Ivan Garcia-Bassets, Zhi John Lu* and Dong Wang* (2020) Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer. Cell Research 30(1):34-49 (1contributed equally, *co-corresponding authors)(IF:18)
? Chang Tan1, Jingyi Cao1, Lu Chen1, Xiaochen Xi, Siqi Wang, Yumin Zhu, Liuqing Yang, Longteng Ma, Dong Wang, Jianhua Yin*, Ti Zhang* and Zhi John Lu* (2019) Noncoding RNAs serve as diagnosis and prognosis biomarkers for hepatocellular carcinoma Clinical Chemistry 65:7 (1 contributed equally, * co-corresponding) (IF: 8)
?  Yang Yang1, Lei Chen1, Jin Gu1, Hanshuo Zhang1, Jiapei Yuan, Qiuyu Lian, Guishuai Lv, Siqi Wang, Yang Wu, Yu-Cheng T. Yang, Dongfang Wang, Yang Liu, Jing Tang, Guijuan Luo, Yang Li, Long Hu, Xinbao Sun, Dong Wang, Mingzhou Guo, Qiaoran Xi, Jianzhong Xi, Hongyang Wang*, Michael Q. Zhang* and Zhi John Lu* (2017) Recurrently deregulated lncRNAs in hepatocellular carcinoma. Nature Communications 8, 14421 (1contributed equally) (IF: 12)
?  Yang Eric Li1, Mu Xiao1, Binbin Shi1, Yu-Cheng T. Yang, Dong Wang, Fei Wang, Marco Marcia and Zhi John Lu* (2017) Identification of high-confidence RNA regulatory elements by combinatorial classification of RNA-protein binding sites. Genome Biology 18:169 (1contributed equally) (IF: 14)
?  Boqin Hu1, Yu-Cheng T. Yang1, Yiming Huang, Yumin Zhu and Zhi John Lu* (2017) POSTAR: a platform of post-transcriptional regulation coordinated by RNA binding proteins. Nucleic Acids Research 45 (D1): D104-D114 (1contributed equally) (IF: 11)
? Long Hu, Zhiyu Xu, Boqin Hu and Zhi John Lu* (2017) COME: a robust coding potential calculator for lncRNA identification and characterization based on multiple features. Nucleic Acids Research 45 (1): e2  (IF: 11)
代表性合作
? Rui Xiao, Jia-Yu Chen, Zhengyu Liang, Daji Luo, Geng Chen, Zhi John Lu, Yang Chen, Bing Zhou, Hairi Li, Xian Du, Yang Yang, Mingkui San, Xintao Wei, Wen Liu, Eric Lecuyer, Brenton R. Graveley, Gene W. Yeo, Christopher B. Burge, Michael Q. Zhang, Yu Zhou and Xiang-Dong Fu (2019) Pervasive Chromatin-RNA Binding Protein Interactions Enable RNA-Based Regulation of Transcription. Cell 178, 107–121
?  Sai Luo, J. Yuyang Lu, Lichao Liu, Yafei Yin, Chunyan Chen, Xue Han, Bohou Wu, Ronggang Xu, Wei Liu, Pixi Yan, Wen Shao, Zhi Lu, Haitao Li, Jie Na, Fuchou Tang, Jianlong Wang, Yong E. Zhang, Xiaohua Shen (2016) Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent Cells. Cell Stem Cell 18, 1–16
? Gerstein MB, Joel Rozowsky, Koon-Kiu Yan, …, Lu Z, …, Robert Waterston (2014) Comparative Analysis of the Transcriptome across Distant Species. Nature 512(7515):445-448.
? ENCODE Project Consortium#. (2012) An Integrated Encyclopedia of DNA Elements in the Human Genome. Nature 489, 57–74. (#Lu Z is part of ENCODE Consortium) [Cover Story]
?  Gerstein MB 1*, Lu ZJ1, Van Nostrand EL1, Cheng C1, Arshinoff BI1, et al. (2010) Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science 330(6012): 1775-1787 (120 co-first authors, *15 co-corresponding authors, ~150 authors in total) [Cover Story]


Contact information


Tel. /FAX: +86-10-62789217
E-mail: lulab1AT tsinghua.edu.cn
Lab page: http://lulab.life.tsinghua.edu.cn

MOE Key Lab of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China