Ting ZHU, Ph.D.

Professor

1999.9-2003.1 B.E. in Engineering Mechanics (early graduation with highest honor), Tsinghua University

2003.9-2005.9 M.S. in Mechanical Engineering, MIT (Advisor: Roger D. Kamm)

2005.9-2010.6 Ph.D. in Biomedical Engineering, Harvard-MIT Division of Health Sciences and Technology (Advisor: Jack W. Szostak)

2010.7-2011.9 Postdoctoral Associate, MIT/Massachusetts General Hospital (Advisors: Maria T. Zuber, Gary Ruvkun)

2011.10-present Assistant Prof., Associate Prof., Professor, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University

Research interest

Synthetic biology, Chemical biology, Mirror-image biology systems

Selected publications

1. Ling JJ#, Fan C#, Qin H, Wang M, Chen J, Wittung-Stafshede P, Zhu TF*. Mirror-image 5S ribonucleoprotein complexes. Angewandte Chemie International Edition, 59:3724-3731, (2020).
2. Qin N#*, Liang P#, Wu C#, Wang G, Xu Q, Xiong X, Wang T, Zolfo M, Segata N, Qin H, Knight R, Gilbert JA*, Zhu TF*. Longitudinal survey of microbiome associated with particulate matter in a megacity. Genome Biology, 21:55, (2020).
3. Zhang B, Deng Q, Zuo C, Yan B, Zuo C, Cao XX, Zhu TF, Zheng JS*, Liu L*. Ligation of soluble but unreactive peptide segments in the chemical synthesis of Haemophilus Influenzae DNA ligase. Angewandte Chemie International Edition, 58:12231-12237, (2019).
4. Wang M#, Jiang W#, Liu X#, Wang J#, Zhang B, Fan C, Liu L, Pena-Alcantara G, Ling J, Chen J, Zhu TF*. Mirror-image gene transcription and reverse transcription. Chem, 5:848-857, (2019).
5. Liu X, Zhu TF*. Sequencing mirror-image DNA chemically. Cell Chemical Biology, 25:1-6, (2018).
6. Wang G#, Du M#, Wang J*, Zhu TF*. Genetic variation may confound analysis of CRISPR-Cas9 off-target mutations. Cell Discovery, 4:18, (2018).
7. Kayani MU#, Doyle SM#, Sangwan N, Wang G, Gilbert JA*, Christner BC*, Zhu TF*. Metagenomic analysis of basal ice from an Alaskan glacier. Microbiome, 6:123, (2018).
8. Jiang W#, Zhang B#, Fan C#, Wang M#, Wang J, Deng Q, Liu X, Chen J, Zheng J, Liu L*, Zhu TF*. Mirror-image polymerase chain reaction. Cell Discovery, 3:17037, (2017).
9. Pontefract A, Zhu TF, Walker VK, Hepburn H, Lui C, Zuber MT, Ruvkun G, Carr CE*. Microbial diversity in a hypersaline sulfate lake: a terrestrial analog of ancient Mars. Frontiers in Microbiology, 8:1819, (2017).
10. Xu W#, Jiang W#, Wang J#, Yu L#, Chen J, Liu X, Liu L*, Zhu TF*. Total chemical synthesis of a thermostable enzyme capable of polymerase chain reaction. Cell Discovery, 3:17008, (2017).
11. Su HW#, Zhu JH#, Li H, Cai RJ, Ealand C, Wang X, Chen YX, Kayani MU, Zhu TF, Moradigaravand D, Huang H, Kana BD, Javid B*. The essential mycobacterial amidotransferase GatCAB is a modulator of specific translational fidelity. Nature Microbiology, 1:16147, (2016).
12. Wang Z#, Xu W#, Liu L*, Zhu TF*. A synthetic molecular system capable of mirror-image genetic replication and transcription. Nature Chemistry, 8(7):698-704, (2016). (Highlighted by Nature, Scientific American, C&EN News, and F1000Prime)
13. Jiang W*, Zhu TF*. Targeted isolation and cloning of 100-kb microbial genomic sequences by Cas9-assisted targeting of chromosome segments. Nature Protocols, 11(5):960-975, (2016).
14. Jiang W, Zhao X, Gabrieli T, Lou C*, Ebenstein Y*, Zhu TF*. Cas9-Assisted Targeting of CHromosome segments CATCH enables one-step targeted cloning of large gene clusters. Nature Communications, 6:8101, (2015).
15. Zheng Y#, Kayani MU#, Zhu TF*. Rapid identification of multi-strain HBV infection in patient by high-throughput DNA sequencing. Quantitative Biology, 3(2):103-106, (2015).
16. Jiang W, Liang P, Wang B, Fang J, Lang J, Tian G, Jiang J, Zhu TF*. Optimized DNA extraction and metagenomic sequencing of airborne microbial communities. Nature Protocols, 10(5):768-779, (2015).
17. Cao C, Jiang W#, Wang B#, Fang J, Lang J, Tian G*, Jiang J*, Zhu TF*. Inhalable microorganisms in Beijing’s PM2.5 and PM10 pollutants during a severe smog event. Environmental Science & Technology, 48(3):1499-1507, (2014). (Web of Science ‘Highly Cited Paper’: top 1% of the field; Highlighted by Nature, Scientific American, Popular Science, The Scientist, Los Angeles Times, and Business Insider)

*Corresponding author(s)
#Equal contributions

 

Contact information

Biotechnology Building 4-201
School of Life Sciences
Tsinghua University
Beijing 100084, China
Tel: 86-10-62797325
Email: tzhu@tsinghua.edu.cn

Lab website: http://zhulab.life.tsinghua.edu.cn