Hang SHI     Ph.D.

Assistant Professor

1992-1996  Tsinghua University, China／B.S.

1997-2003 University of Massachusetts Amherst,USA and The Cold Spring Harbor Laboratory,USA／P h .D.

2004－2006  Institute of Medicine,USA  ／Postdoctoral Fellow

2006－2017  Rockefeller University ,USA ／Senior Research Associate

2017-present School of Life Sciences, Tsinghua University, China／Assistant Investigator

Research interest

My laboratory combines structural and functional approaches to investigate, from the molecular perspective, the production, metabolism, function and related regulatory mechanisms of intracellular RNA, and develop biological and medical tools. In addition, we also apply multiple structural biology methods to understand the formation and function of cellular organelles (for instance, cillia).

Selected publications

1. Shao W，Yang J, He M, Yu X-Y, Lee C H, Yang Z, Joyner A L, Anderson K V, Zhang J, Tsou M-F B, Shi H* & Shi S-H.

(2020) Centrosome anchoring regulates progenitor properties and cortical formation.Nature 580, 106–112.

2. Qi Hao, Boyue Zhang, Kangning Yuan, Hangshi* and Gunter Blobel .(2018) Electron microscopy of Chaetomium pom152 shows the assembly of ten-bead string.Cell Discovery 4, Article number :56 .

3.   Li, X., Wang, J., Coutavas, E., Shi. H., Hao, Q., and Blobel, G. (2016) Structure of Niemann-Pick disease protein 1. Proc. Natl. Acad. Sci. U. S. A, 113, 8212-8217.

4.  Singh, N., Blobel, G. Shi,H. *(2015) Hooking She3p onto She2p for myosin-mediated cytoplasmic mRNA  transport. Proc.Natl.Acad.Sci.U.S.A,112, 142-147.

5. Shi,H.*, Singh, N., Esselborn, F. and Blobel, G. (2014) Structure of a myosin•adaptor complex and pairing by cargo. Proc. Natl.Acad.Sci.U.S.A,111, 1082-1090.

Contact information

Tel：+86-10-62773562

Fax：+86-10-62773562

E-mail：hangshi@tsinghua.edu.cn

web:http://hshi-lab.life.tsinghua.edu.cn/#/home