Hongwei Wang, Ph.D.

Professor and Dean


1992-1996    B.S., Department of Biological Sciences and Biotechnology, Tsinghua University

1996-2001    Ph.D., Department of Biological Sciences and Biotechnology, Tsinghua University

2001-2006    Postdoctoral Fellow, Life Sciences Division, Lawrence Berkeley National Laboratory, USA

2006-2008    Research Scientist, Life Sciences Division, Lawrence Berkeley National Laboratory, USA

2009-2011    Tenure-Track Assistant Professor, Department of Molecular Biophysics and Biochemistry, Yale University, USA

2010.12-      Professor, School of Life Sciences, Tsinghua University

2016.04-      Dean, School of Life Sciences, Tsinghua University

 

Research interest


Our research group is devoted to elucidating the architecture and mechanism of macromolecular complexes and assemblies with cryo-electron microscopy. More specifically, we are interested in:
1 Methodology development for more efficient and high resolution cryo-electron microscopy;
2. The coordination mechanisms of cytoskeleton and membrane systems;
3. The mechanism and regulations of nucleic acid quality control.

Selected publications


1. Jin W, Wang J, Liu CP, Wang HW*, Xu RM*. (2020) Structural Basis for pri-miRNA Recognition by Drosha. Mol. Cell, doi: 10.1016/j.molcel.2020.02.024. [Epub ahead of print]
2. Zheng L, Chen Y, Li N, Zhang J, Liu N, Liu J, Dang W, Deng B, Li Y, Gao X, Tan C, Yang Z, Xu S, Wang M, Yang H, Sun L, Cui Y, Wei X, Gao P*, Wang HW*, Peng H*. (2020) Robust ultraclean atomically thin membranes for atomic-resolution electron microscopy. Nat. Commun., 11(1):541.
3. Fan X, Wang J, Zhang X, Yang Z, Zhang JC, Zhao L, Peng HL, Lei J*, Wang HW*. (2019) Single particle cryo-EM reconstruction of 52 kDa streptavidin at 3.2 Angstrom resolution. Nat. Commun., 10(1):2386.
4. Wang J, Wang J, Hu M, Wu S, Qi J, Wang G, Han Z, Qi Y, Gao N, Wang HW*, Zhou JM*, Chai J*. (2019) Ligand-triggered allosteric ADP release primes a plant NLR complex. Science, 364(6435). pii: eaav5868.
5. Wang J, Hu M, Wang J, Qi J, Han Z, Wang G, Qi Y, Wang HW*, Zhou JM*, Chai J*. (2019) Reconstitution and structure of a plant NLR resistosome conferring immunity. Science, 364(6435). pii: eaav5870.
6. Liu N, Zhang J, Chen Y*, Liu C, Zhang X, Xu K, Wen J, Luo Z, Chen S, Gao P, Jia K, Liu Z, Peng H*, Wang HW*. (2019) Bioactive Functionalized Monolayer Graphene for High-Resolution Cryo-Electron Microscopy. J. Am. Chem. Soc., 141(9):4016-4025.
7. Liu Z, Wang J, Cheng H, Ke X, Sun L, Zhang Q, Wang HW*. (2018) Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate. Cell, 173(5):1191-1203
8. Mei K, Li Y, Wang S, Shao G, Wang J, Ding Y, Luo G, Yue P, Liu JJ, Wang X, Dong MQ, Wang HW*, Guo W*. (2018) Cryo-EM structure of the exocyst complex. Nat. Struct. Mol. Biol., 25(2):139-146 (Cover)
9. Fan X, Zhao L, Liu C, Zhang JC, Fan K, Yan X, Peng HL, Lei J*, Wang HW*. (2017) Near-Atomic Resolution Structure Determination in Over-Focus with Volta Phase Plate by Cs-Corrected Cryo-EM. Structure, 25(10):1623-1630
10. Xu J, Zhao L, Xu Y, Zhao W, Sung P*, Wang HW*. (2017) Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange. Nat. Struct. Mol. Biol., 24(1):40-46

 

Awards


The National Science Fund for Distinguished Young Scholars, 2018
Winner for Tan Jiazhen Life Sciences Innovation Award, 2018
Winner for XPLORER PRIZE, 2019

Contact information


Tel: +86-10-62772390 (office)
 +86-10-62798651 (lab)
E-mail: hongweiwang@tsinghua.edu.cn
Lab website: http://cryoem.life.tsinghua.edu.cn/