Jiawei WANG, Ph.D.


1996-2001, B.S, Department of Materials and Engineering, University of Science and Technology of China;

2001-2005, Ph.D, Institute of Physics, Chinese Academy of Sciences;

2005-2008, Postdoctoral fellow, Argonne National Laboratory, IL / Macromolecular Crystallography Laboratory – National Cancer Institute at Frederick, MD / SAIC-Frederick Inc. MD, USA;

2008-2011, Senior Engineer, Department of Biological Science and Biotechnology, Tsinghua University;

2011-now,  Assistant Professor, School of Life Sciences, Tsinghua University.


Research interest

Membrane protein crystallography: The research interests focus on the determination of the crystal structures of important membrane proteins, and the development of the related structural analysis technologies.

Selected publications

  1. J. Davis, J. W. Wang, J. E. Tropea, D. Zhang, Z. Dauter, D. S. Waugh, A. Wlodawer (2008) Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri. Protein Science17, 2167-2173.

  2. J. W. Wang, M. Dauter, R. Alkire, A. Joachimiak, Z. Dauter (2007) Triclinic lysozyme at 0.65 ? resolution, Acta Cryst. D63, 1254-1268.

  3. J. W. Wang, M. Dauter, Z. Dauter (2006) What can be done with a good crystal and an accurate beamline? Acta Cryst. D62, 1475-1483.

  4. J. W. Wang, J. R. Chen, Y. X. Gu, C. D. Zheng, H. F. Fan (2004) Direct-method SAD phasing with partial-structure iteration: towards automation, Acta Cryst. D60, 1991-1996.

  5. J. W. Wang, J. R. Chen, Y. X. Gu, C. D. Zheng, F. Jiang, H. F. Fan (2004) Optimizing the error term in direct-method SAD phasing, Acta Cryst.D60, 1987-1990.

  6. J. W. Wang, J. R. Chen, Y. X. Gu, C. D. Zheng, F. Jiang, H. F. Fan, T. C. Terwilliger, Q. Hao (2004) “SAD phasing by combination of direct methods with the SOLVE/RESOLVE procedue”, Acta Cryst. D60, 1244-1253.

  7. Zhou N, Wang H*, Wang J*. EMBuilder: A Template Matching-based Automatic Model-building Program for High-resolution Cryo-Electron Microscopy Maps. Scientific reports. 2017;7:2664.

  8. Rao Q, Liu M, Tian Y, Wu Z, Hao Y, Song L, Qin Z, Ding C, Wang HW*, Wang J*, Xu Y*. Cryo-EM structure of human ATR-ATRIP complex. Cell research. 2017.

  9. Bao Z, Qi X, Hong S, Xu K, He F, Zhang M, Chen J, Chao D, Zhao W, Li D, Wang J*, Zhang P*. Structure and mechanism of a group-I cobalt energy coupling factor transporter. Cell research. 2017;27:675-87.

  10. Wang J*, Chai J, Wang H. Structure of the mouse Toll-like receptor 13 ectodomain in complex with a conserved sequence from bacterial 23S ribosomal RNA. The FEBS journal. 2016;283:1631-5 (Cover, review).

  11. Gao S, Pan M, Zheng Y, Huang Y, Zheng Q, Sun D, Lu L, Tan X, Tan X, Lan H, Wang J, Wang T, Wang J*, Liu L*. Monomer/Oligomer Quasi-Racemic Protein Crystallography. Journal of the American Chemical Society. 2016;138:14497-502.

  12. Wang J, Wang W, Song W, Han Z, Zhang H, Chai J*, Wang H*, Wang J*. An improved method for phasing crystal structures with low non-crystallographic symmetry using cryo-electron microscopy data. Protein & cell. 2015;6:919-23.

  13. Song W, Wang J, Han Z, Zhang Y, Zhang H, Wang W, Chang J, Xia B, Fan S, Zhang D, Wang J*, Wang HW*, Chai J*. Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13. Nature structural & molecular biology. 2015;22:782-7.

  14. Luo P, Yu X, Wang W, Fan S, Li X*, Wang J*. Crystal structure of a phosphorylation-coupled vitamin C transporter. Nature structural & molecular biology. 2015;22:238-41 (Cover).