Peng Jiang, Ph.D

Principal Investigator, Tenure-track Assistant ProfessorInvestigator


1999-2003  B.S., Anhui University, School of Life Sciences.
2003-2008  Ph.D., University of Science and Technology of China, School of Life
           Sciences.
2008-2013  Postdoc, University of Pennsylvania, Perelman School of Medicine.
2013-2014  Research Associate, University of Pennsylvania, School of Medicine.
2014-     Tenure-track Assistant Professor, Tsinghua University, School of Life Sciences.
2020-      Principal Investigator, Tsinghua-Peking Joint Center for Life Sciences

 

Research interest


The metabolism within and outside of tumour cells is markedly different from that of normal cells in differentiated tissues. Metabolic reprogramming usually confers pro-proliferative and/or survival advantages to tumour cells. Emerging evidence suggest that metabolic alteration is ultimately linked to genetic changes that contribute to cell fate decisions. Currently, we are interested in how cancer cells rewire their metabolism, particularly the role of the most frequently mutated gene p53 in tumour cell metabolism. We are also interested in how nutrient alteration is sensed by cancer cells and how metabolic remodeling influences anti-tumour immune responses. Understanding these issues will have great value for defining and targeting a therapeutic window for treating cancer.

 

Selected publications


Deng L, Yao P, Li L, Ji F, Zhao S, Xu C, Lan X, Jiang P*. p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival. Nature Communications, (2020) 11, 1755-18; doi:10.1038/s41467-020-15573-6

Li L, Mao Y, Zhao L, Li L, Wu J, Zhao M, Du W, Yu L, Jiang P*. p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis. Nature. (2019) 567(7747):253-256.

Li L#, Li L#, Li W, Chen T, Bin Zou, Zhao L, Wang H, Wang X, Xu L, Liu X, Wang D, Li B, Mak TW, Du W*, Yang X*, Jiang P*. TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation. Nature Communications. (2018), Nov 8; 9(1):4683.

Yao P, Sun H, Xu C, Chen T, Zou B, Jiang P*, Du W*. Evidence for a direct cross-talk between malic enzyme and the pentose phosphate pathway via structural interactions. J Biol Chem. (2017) Oct 13; 292(41):17113-17120.

Jiang P, Du W and Yang X*. Critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation. Cell Cycle. (2013), 12(24): 3720-3726.

Du W#, Jiang P#, Mancuso A, Stonestrom A, Brewer M, Minn AJ, Mak TW, Wu M* and Yang X*. TAp73 enhances the pentose phosphate pathway and supports cell proliferation. Nature Cell Biology. (2013), Aug. 15, 991–1000.

Jiang P#, Du W#, Mancuso A, Wellen KE, Yang X*. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature. (2013), Jan. 493: 689-693. 

Jiang P#, Du W#, Wang X, Mancuso A, Gao X, Wu M* and Yang X*. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nature Cell Biology. (2011) Mar.13: 310-316.

 


Contact information


Email: pengjiang@mail.tsinghua.edu.cn, or jiang-lab@tsinghua.edu.cn
Phone:010-62786079 (Office), or 010-62783063 (Laboratory)