Zhifu Han, Ph.D.

Research Associate Professor

1991.9-1996.7      Shanxi Medical University, Bachelor of Medicine.

1997.9-2000.7    Shanxi Medical University,  Master of Midicine

2000.9-2003.7     Peking Union Medical College, Ph.D.

2004.8-2010.12      National Institute of Biological Sciences, Beijing

2011.1-present     School of Life sciences, Tsinghua University


Research interest

Structural study of plant receptor-like kinases.


Selected publications

1            Song W, Liu L, Wang J, Wu Z, Zhang H, Tang J, Lin G, Wang Y, Wen X, Li W, Han Z*, Guo H*, Chai J*.Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth. Cell research 26, 674-685, (2016).

2            Song W*, Wang J*, Han Z*, Zhang Y, Zhang H, Wang W, Chang J, Xia B, Fan S, Zhang D, Wang J, Wang HW, Chai J. Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13. Nature structural & molecular biology 22, 782-787, (2015).

3            Han Z, Sun Y, Chai J.Structural insight into the activation of plant receptor kinases. Current opinion in plant biology 20, 55-63, (2014).

4            Sun Y, Li L, Macho AP, Han Z*, Hu Z, Zipfel C, Zhou JM*, Chai J*. Structural basis for flg22-induced activation of the Arabidopsis FLS2-BAK1 immune complex. Science 342, 624-628, (2013).

5            Sun Y*, Han Z*, Tang J, Hu Z, Chai C, Zhou B, Chai J. Structure reveals that BAK1 as a co-receptor recognizes the BRI1-bound brassinolide. Cell research 23, 1326-1329, (2013).

6            Gao H, Wu X, Chai J, Han Z*.Crystal structure of a TALE protein reveals an extended N-terminal DNA binding region. Cell research 22, 1716-1720, (2012).

7            She J*, Han Z*, Kim TW, Wang J, Cheng W, Chang J, Shi S, Wang J, Yang M, Wang ZY, Chai J.Structural insight into brassinosteroid perception by BRI1. Nature 474, 472-476, (2011).

8            Han Z*, Niu T*, Chang J, Lei X, Zhao M, Wang Q, Cheng W, Wang J, Feng Y, Chai J.Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature 464, 1205-1209, (2010).

9            Han Z, Xing X, Hu M, Zhang Y, Liu P, Chai J. Structural basis of EZH2 recognition by EED. Structure 15, 1306-1315, (2007).

10          Han Z, Guo L, Wang H, Shen Y, Deng XW, Chai J. Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5. Molecular cell 22, 137-144, (2006).



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