Dongming XING, Ph.D.

Associate Professor

1990-1999,M.s.,Ph.D. Peking Union Medical College,
2000-2002,Postdoc,  Tsinghua University.
2001,Visiting Scholar, Johns Hopkins University
2002--present ,School of Life Sciences, Tsinghua University

Research interest

Drug discovery from traditional Chinese medicine and natural herbs
Influence of cerebral ischemia-reperfusion on brain function and its molecular mechanisms
Targeting site of natural small molecule drug and the signal transduction

Major Research Achievements

Drug Discovery:
Shuanghuoganmao Capsule(common clod): Being awarded with New Drug Certificate by SFDA in 2009.
Jiuweilvping particles(Anxiety):  received a certificate from SFDA in 2008.
“BC-21”(Hyperlipidemia): clinical trials permits  by SFDA(2004L00158),clinical phase I,  II trials completed.
“TS-10”(Depression): clinical trials permits  by  SFDA(2005L01609),clinical phase I, II trials completed.
“YL102”(Depression): clinical trials permits  by  SFDA(2004L04312),clinical phase I trial completed.
Patent& transfer:
Application of Invention patent:15  
transfer ratio: 70%


Selected publications

Li Hui-ying, Yuan Zhi-yi, Wang Yu-gang, Wan Hong-jiao, Hu Jun, Chai Yu-shuang, Lei Fan, Xing Dong-ming and Du Li-jun. Role of baicalin in regulating Toll-like receptor 2/4 after ischemic neuronal injury. Chin. Med. J. 2012;125(9):1586-1593 IF:0.864
Jun Hu, Han Lin, Jia Shen, Jiaqi Lan, Chao Ma, Yunan Zhao, Fan Lei, Dongming Xing and Lijun Du. Developmental toxicity of orally administered pineapple leaf extract in rats. Food and Chemical Toxicology, 2011, 49,1455-1463.
Hu Jun, Zhao Yunan, Ma Chao, Wang Weiyu, Xing Dongming, Du Lijun. Acid hytrolytic method for determination of Ginkgo Biloba total flavonoids in rat plasma by HPLC for pharmacokinetic studies. Tsinghua Science and Technology, 2010,15(4),452-459.
Wang Xiukun, Zhang Lujun, Hua Lei, Xing Dongming, Du Lijun. Effect of flavonoids in Scutellariae Radix on depression-like behavior and brain rewards: Possible in dopamine system. Tsinghua Science and Technology, 2010,15(4),460-466.
Jiaqi Lan, Fan Lei, Lei Hua, Yugang Wang, Dongming Xing and Lijun Du.(2009)
Transport behavior of ellagic acid of pomegranate leaf tannins and its correlation with total cholesterol alteration in HepG2 cells. Biomedical Chromatography, 23: 531-536

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