陈国强

2020-07-16 14:38:06

陈国强 博士

教授,博士生导师,长江学者特聘教授,国家杰出青年基金获得者

1981-1985  广州华南理工大学,学士
1986-1989  奥地利格拉茨工业大学,博士
1990-1992  英国诺丁汉大学,博士后
1992-1994  加拿大阿尔伯达大学,博士后
1994-1997  清华大学生命科学学院,副教授
1997-至今  清华大学生命科学学院,教授、博导

● 研究兴趣、领域:

合成生物学、微生物代谢工程、生物材料、工业生物技术

● 代表性论文:

1. Chen GQ and Jiang XR. Engineering Microorganisms for Improving Polyhydroxyalkanoate Biosynthesis. Current Opinion in Biotechnology 53 (2018) 20-25
2. Ouyang PF, Wang H, Hajnal I, Wu W. Guo YY and Chen GQ. Increasing Oxygen Availability for Improving PHB Production by Halomonas. Metabolic Engineering 45 (2018) 20-31
3. Zhang XC, Guo YY, Liu X, Chen XG, Wu Q, Chen GQ. Engineering Cell Wall Synthesis Mechanism for Enhanced PHB Accumulation in E. coli. Metabolic Engineering 45 (2018) 32-42
4. Chen GQ and Jiang XR. Next Generation Industry Biotechnology Based on Exremophiles. Current Opinion in Biotechnology 50 (2018) 94-100
5. Ye JW, Hu DK, Che XM, Jiang XR, Li T, Chen JC, Zhang HQ, Chen GQ. Engineering of Halomonas bluephagenesis for Low Cost Production of Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) from Glucose. Metabolic Engineering 47 (2018) 143-152
6. Qin Q, Ling C, Zhao YQ, Yang T, Yin J, Guo YY and Chen GQ. CRISPR/Cas9 Editing Genome of Extremophile Halomonas spp. Metabolic Engineering 47 (2018) 219-229
7. Wei DX, Dao JW, Chen GQ. Micro-Ark for Cells: Highly Open Porous Polyhydroxyalkanoate Microspheres as Injectable Scaffolds for Tissue Regeneration. Advanced Materials 30 (2018) 1802273 DOI: 10.1002/adma.201802273
8. Ling C, Qiao GQ, Shuai BW, Olavarria K, Yin J, Xiang RJ, Shen YH, Song KN, Guo YY, Chen GQ. Engineering NADH/NAD+ Ratio in Halomonas bluephagenesis for Enhanced Production of Polyhydroxyalkanoates (PHA).  Metabolic Engineering 49 (2018) 275-286.
9. Li MY, Chen XB, Che XM, Zhang HQ, Wu LP, Du HT and Chen GQ. Engineering Pseudomonas entomophila for Synthesis of Copolymers of 3-Hydroxybutyrate and Medium-chain-length 3-Hydroxyalkanoates. Metabolic Engineering 52 (2018) 253-262
10. Ling C, Qiao GQ, Shuai BW, Song KN, Jiang XR, Chen GQ. Engineering Self-flocculating Halomonas campaniensis for Wastewaterless Open and Continuous Fermentation. Biotechnology and Bioengineering 116 (2019) 805-815
11. Chen Y, Chen XY, Du HT, Zhang X, Ma YM, Chen JC, Ye JW, Jiang XR, Chen GQ. Chromosome Engineering the TCA Cycle in Halomonas bluephagenesis for Production of Copolymers of 3-Hydroxybutyrate and 3-Hydroxyvalerate (PHBV). Metabolic Engineering 54 (2019) 69-82
12. Shen R, Ning ZY, Lan YX, Chen JC and Chen GQ. Manipulation of Polyhydroxyalkanoate Granular sizes in Halomonas bluephagenesis. Metabolic Engineering 54 (2019) 117-126.
13. Wang Y, Ling C, Chen Y, Jiang XR and Chen GQ, Microbial Engineering for Easy Downstream Processing. Biotechnology Advances 37 (2019) 107365. 10.1016/j.biotechadv.2019.03.004
14. Ye JW, Hu DK, Yin J, Huang WZ, Xiang RJ, Zhang LZ, Wang X, Han JN, Chen GQ. Stimulus Response-based Fine-Tuning of Polyhydroxyalkanoate Pathway in Halomonas. Metabolic Engineering 57 (2019) 85-95
15. Zheng Y, Meng FK, Wei WJ; Sun Z; Lou CB and Chen GQ. A Tight Cold-inducible Switch Built by Coupling Thermosensitive Transcriptional and Proteolytic Regulatory Parts. Nucleic Acids Research 47 (21) e137 (2019) doi: 10.1093/nar/gkz785 (2019)
16. Zheng Y, Chen JC, Ma YM, Chen GQ. Engineering Biosynthesis of Polyhydroxyalkanoates (PHA) for Diversity and Cost Reduction. Metabolic Engineering 58 (2020) 82-93
17. Yu LP, Yan X, Zhang X, Chen XB, Wu Q, Jiang XR, Chen GQ. Biosynthesis of Functional Polyhydroxyalkanoates by Engineered Halomonas bluephagenesis Metabolic Engineering 59 (2020) 119-130

● 联系方式:

电话:010-62783844(office)     010-62772676(lab)

邮箱:chengq@tsinghua.edu.cn