欧光朔

2020-07-16 14:51:18
   

欧光朔 博士

研究员,博导,国家杰出青年基金获得者


1994-2001 中国农业大学生物学院,获理学学士、硕士学位

2001-2006 美国加利福尼亚州大学戴维斯分校,获细胞和发育生物学博士学位

2007-2011 美国加利福尼亚州大学旧金山分校/霍华德休斯医学研究院 (HHMI),博士后

2011-2013   中国科学院生物物理研究所,研究员,博士生导师

现任清华大学研究员、博士生导师

 

 

●  研究兴趣、领域:


细胞生物学和神经发育。我们以模式动物和哺乳类细胞为对象,综合运用超分辨活体成像、冷冻和常温电镜技术、条件性基因编辑和生化分析等方法,研究细胞骨架和信号分子调控不对称细胞分裂、定向细胞迁移、以及纤毛发生的机理。

●  代表性论文:


1. Xie C, Li L, Li M, Shao W, Zuo Q, Huang X, Chen R, Li W, Brunnbauer M, ?kten Z, Chen L*, Ou G*. Optimal Sidestepping of Intraflagellar Transport Kinesins Regulates Structure and Function of Sensory Cilia. EMBO J. 2020 in press
2. Jia R, Li D, Li M, Chai Y, Liu Y, Xie Z, Shao W, Xie C, Li L, Huang X, Chen L, Li W, Ou G. Spectrin-based membrane skeleton supports ciliogenesis. PLoS Biol. 2019 Jul 12;17(7):e3000369.
3. Yang Y, Zhang Y, Li WJ, Jiang Y, Zhu Z, Hu H, Li W, Wu JW, Wang ZX, Dong MQ, Huang S, Ou G. (2017) Spectraplakin Induces Positive Feedback between Fusogens and the Actin Cytoskeleton to Promote Cell-Cell Fusion. Developmental Cell. 41(1):107-120.
4. Feng G, Zhu Z, Li W, Chai Y, Dong M and Ou G. (2017) Hippo Kinases Maintain Polarity during Directional Cell Migration in C. elegans. EMBO J. 36(3):334-345.
5. Yi P, Li WJ, Dong MQ, and Ou G*. Dynein-Driven Retrograde Intraflagellar Transport Is Triphasic in C. elegans Sensory Cilia. Current Biology 2017 May 22;27(10):1448-1461
6. Li W, Yi P, Zhu Z, Zhang X, Li W, Ou G. (2017) Centriole translocation and degeneration during ciliogenesis in Caenorhabditis elegans neurons. EMBO J. 36(17):2553-2566.
7. Zhu Z, Chai Y, Jiang Y, Li WJ, Hu H, Li W, Wu J, Wang Z, Huang S and Ou G. (2016) Functional Coordination of WAVE and WASP in C. elegans Neuroblast Migration. Developmental Cell. 39(2):224-238.
8. Tian D, Diao M, Jiang Y, Sun L, Zhang Y, Chen Z, Huang S and Ou G*. Anillin regulates neuronal migration and neurite growth by linking RhoG to the actin cytoskeleton. Current Biology. 2015 May 4; 25(9):1135-45.
9. Shen Z, Zhang X, Chai Y, Zhu Z, Yi P, Feng G, Li W and Ou G. (2014) Conditional Knockouts Generated by Engineered CRISPR-Cas9 Endonuclease Reveal the Roles of Coronin in C. elegans Neural Development. Developmental Cell. 30(5):625-36.
10. Cheng Z, Yi P, Wang X, Chai Y, Feng G, Yang Y, Liang X, Zhu Z, Li W *, and Ou G.* (2013) Conditional targeted genome editing using somatically expressed TALENs in C. elegans. Nature Biotechnology. 31(10):934-7.
11. Ou, G.*, Stuurman N, D'Ambrosio, M and R.D. Vale*. (2010) Polarized myosin produces unequal size daughters during asymmetric cell division. Science. 330(6004):677-80.
12. Ou, G., Blacque, O.E., Snow, J.J., Leroux, M.R., and J.M. Scholey (2005) Functional Coordination of Intraflagellar Transport Motors. Nature.  436(7050):583-7.

●  联系方式:


电    话:+86-10-62794766

E-mail:guangshuoou@mail.tsinghua.edu.cn