李 蓬

2020-07-16 14:51:18
   

李蓬 博士

教授,中科院院士,长江特聘教授,国家杰出青年基金获得者


1987年       北京师范大学                                                                              学士

1995年       美国加州大学圣地亚哥分校                                                        博士

1995-1996 新加坡国立大学分子与细胞生物学研究所                                   博士后

1996-1997 美国达拉斯德州大学西南医学中心Howard Hughes医学研究所  博士后

1997-2003 新加坡分子和细胞生物学研究所                                                 助理教授及研究室主任

2003-2006 香港科技大学生物系,                                                               助理教授&副教授(获终身制)

2006-至今  清华大学生命科学学院                                                               长江学者特聘教授

 

●  研究兴趣、领域:


集中于糖脂代谢的研究,包括脂滴生物学,肥胖、糖尿病和脂肪肝等代谢性疾病发生发展的分子机制。我们发现调控脂滴融合、脂滴-内质网互作的若干重要蛋白质,并且阐明了它们在肥胖、糖尿病和脂肪肝等代谢性疾病发生发展中的作用。

●  开设的课程:


《重大疾病的分子机制》

●  代表性论文:


1. Du X, Zhou L, Aw Y, Mak HY, Xu Y, Rae J, Wang W, Zadoorian A, Hancock S, Osborne B, Chen X, Wu JW, Turner N, Parton RG, Li P*, and Yang H* (2020) ORP5 localizes to ER-lipid droplet contacts and regulates the level of PI(4)P on lipid droplets. J Cell Biol. 219: pii: e201905162.
2. Su L, Zhou L, Chen FJ, Wang H, Qian H, Sheng Y, Zhu Y, Yu H, Gong X, Cai L, Yang X, Xu L, Zhao TJ, Li JZ, Chen X*, Li P* (2019) Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites. EMBO J. 38:e100156.
3. Li Q, Zhao Q, Zhang J, Zhou L, Zhang W, Chua B, Chen Y, Xu L*, Li P* (2019) The Protein Phosphatase 1 Complex Is a Direct Target of AKT that Links Insulin Signaling to Hepatic Glycogen Deposition. Cell Rep. 28:3406-22
4. Xu D, Li Y, Wu L, Li Y, Zhao D, Yu J, Huang T, Ferguson C, Parton RG, Yang H, Li P* (2018) Rab18 promotes lipid droplet growth by tethering the ER to lipid droplets through SNARE and NRZ interactions. J Cell Biol. 217:975-95.
5. Zhou L, Yu M, Arshad M, Wang W, Lu Y, Gong J, Gu Y, Li P*, Xu L* (2018) Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARα Pathway in Adipocytes. Diabetes 67:1935-48.
6. Qian H, Chen Y, Nian Z, Su L, Yu H, Chen FJ, Zhang X, Xu W, Zhou L, Liu J, Yu J, Yu L, Gao Y, Zhang H, Zhang H, Zhao S, Yu L, Xiao RP, Bao Y, Hou S, Li P, Li J, Deng H, Jia W, Li P* (2017) HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage. J Clin Invest. 127: 1353-69.
7. Zhou L, Park SY, Xu L, Xia X, Ye J, Su L, Jeong KH, Hur JH2, Oh H, Tamori Y, Zingaretti CM, Cinti S, Argente J, Yu M, Wu L, Ju S, Guan F,Yang H, Choi CS, Savage DB, Li P* (2015) Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27 deficient mice. Nat Commum. 6, 5949.
8. Wu L, Xu D, Zhou L, Xie B, Yu L, Yang H, Huang L, Ye J, Deng H, Yuan YA, Chen S, Li P* (2014) Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth. Dev Cell 30: 378-93.
9. Sun Z, Gong J, Wu H, Xu W, Wu L, Xu D, Gao J, Wu J, Yang H, Yang M and Li P* (2013) Perilipin1 promotes unilocular lipid droplet formation through activation of Fsp27 in adipocytes. Nat Commum. 4: 1594
10. Wang W, Lv N, Zhang S, Shui G, Qian H, Zhang J, Chen Y, Ye J, Xie Y, Shen Y, Wenk MR, Li P* (2012) Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids. Nat Med. 18: 235-43.
11. Gong J, Sun Z, Wu L, Xu W, Schieber N, Xu D, Shui G, Yang H, Parton RG, Li P* (2011) Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites. J Cell Biol. 195: 953-63.
12. Ye J, Li JZ, Liu Y, Li X, Yang T, Ma X, Li Q, Yao Z, Li P* (2009) Cideb, an ER- and lipid droplet-associated protein, mediates VLDL lipidation and maturation by interacting with apolipoprotein B. Cell Metab. 9: 177-90.
13. Qi J, Gong J, Zhao T, Zhao J, Lam P, Ye J, Li JZ, Wu J, Zhou HM, Li P* (2008) Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissue. EMBO J. 27: 1537-48.
14. Li JZ, Ye J, Xue B, Qi J, Zhang J, Zhou Z, Li Q, Wen Z, Li P*(2007) Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation, Diabetes 56: 2523-32.
15.Zhou Z, Yon Toh S, Chen Z, Guo K, Ng CP, Ponniah S, Lin SC, Hong W, Li P* (2003) Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet. 35: 49-56.

●  荣誉、奖励及参加学术团体的情况:


中美CUSBEA奖学金,1987
新加坡国家青年科学家奖,1999
海外杰出青年人才基金,2005
享受国务院政府特殊津贴,2008
Arthur Kornberg Memorial Lecture award,2008
何梁何利基金生命科学领域科学与技术进步奖,2012年
糖尿病/代谢研究与评论杂志编委,2006-2009
北京生物化学和分子生物学会副理事长,2006 - 至今
亚太国际分子生物学网络组织编辑顾问委员会成员,2008-
脂类生命科学国际会议指导委员会委员,2008 - 至今


●  联系方式:


通信地址:北京市海淀区清华大学生命科学学院(100084)
电话:010-62797133
Email:li-peng@mail.tsinghua.edu.cn
Fax:86-10-62797121