黄善金

2020-07-16 14:44:28
   

黄善金 博士

研究员,博导


1996 原浙江农业大学农学专业 学士
2001 中国农业大学生物学院植物学专业 博士
2001~2006 美国普渡大学生物系 博士后
2006~2016 中国科学院植物研究所 研究员
2014~至今 清华大学生命科学学院 研究员

●  研究兴趣、领域:


综合分子遗传学、生物化学和细胞生物学等手段,利用花粉管为主要细胞学系统研究 1)细胞骨架的结构与功能关系 2)细胞极性生长调控机制。

●  代表性论文:


1. Zhao W, Qu X, Zhuang Y, Wang L, Bosch M, Franklin-Tong VE, Xue Y, Huang S*. Villin Controls the Formation and Enlargement of Punctate Actin Foci in Pollen Tubes. J Cell Sci., 2020, Mar 18; 133 (6). pii: jcs237404

2. Zhang R, Qu X, Zhang M, Jiang Y, Dai A, Zhao W, Cao D, Lan Y, Yu R, Wang H and Huang S*. The Balance between Actin Bundling Factors Controls Actin Architecture in Pollen Tubes. iScience, 2019, 28;16:162-176

3. Jiang Y, Chang M, Lan Y and Huang S*. Mechanism of CAP1-mediated Apical Actin Polymerization in Pollen Tubes. Proc Natl Acad Sci U S A., 2019;116(24):12084-12093

4. Lan Y, Liu X, Fu Y* and Huang S*. Arabidopsis Class I Formins Control Membrane-Originated Actin Polymerization at Pollen Tube Tips. PLOS Genet. 2018, 14(11): e1007789

5. Diao M, Ren S, Wang Q, Qian L, Shen J, Liu Y and Huang S*. Arabidopsis Formin 2 Regulates Cell-to-Cell Trafficking by Capping and Stabilizing Actin Filaments at Plasmodesmata. eLife 2018;7:e36316

6. Jiang Y, Wang J, Xie Y, Chen N and Huang S* . Arabidopsis ADF10 Shapes the Organization of Apical Actin Filaments via Promoting their Turnover and Ordering in Pollen Tubes. J Cell Sci. 2017, 130, 3988-4001

7. Qu X, Zhang R, Zhang M, Diao M, Xue Y and Huang S* . Organizational Innovation of Apical Actin Filaments Drives Rapid Pollen Tube Growth and Turning. Mol Plant. 2017, 10, 930–947

8. Chang M, Li Z and Huang S*. Monomeric G-actin is uniformly distributed in pollen tubes and is rapidly redistributed via cytoplasmic streaming during pollen tube growth. Plant J., 2017, 92(3): 509-519

9. Jiang Y, Zhang M and Huang S*. Analysis of Actin-based Intracellular Trafficking in Pollen Tubes. Methods Mol Biol., 2017, 1662:125-136

10. Zhang R, Chang M, Zhang M, Wu Y, Qu X and Huang S*. The Structurally Plastic CH2 Domain Is Linked to Distinct Functions of Fimbrins/Plastins. J Biol Chem., 2016, 9;291(34):17881-96.

11. Zhang M, Zhang R, Qu X and Huang S* . Arabidopsis FIM5 decorates apical actin filaments and regulates their organization in the pollen tube. J Exp Bot., 2016, 67(11):3407-17

12. Liu X, Qu X, Jiang Y, Chang M, Zhang R, Wu Y, Fu Y and Huang S*. Profilin regulates apical actin polymerization to control polarized pollen tube growth. Mol Plant, 2015, 8(12):1694-709 (cover story)

13. Chang M and Huang S* . Arabidopsis ACT11 modifies actin turnover to promote pollen germination and maintain the normal rate of tube growth. Plant J. , 2015, 83 (3):515-527

14. Wu S, Xie Y, Zhang J, Ren Y, Zhang X, Wang J, Guo X, Wu F, Sheng P, Wang J, Wu C, Wang H, Huang S* and Wan J*. VLN2 regulates plant architecture by affecting microfilament dynamics and polar auxin transport in rice. Plant Cell, 2015, 27(10):2829-2845

15. Qu X, Jiang Y, Chang M, Liu X, Zhang R and Huang S*. Organization and regulation of the actin cytoskeleton in the pollen tube. Front. Plant Sci. , 2015, 8;5:786

16. Wang Q and Huang S* . Visualization of microtubules organization and dynamics in living Arabidopsis embryonic cells. Mol. Plant, 2014;7(8):1397-401

17. Zheng Y, Xie Y, Jiang Y, Qu X and Huang S*. Arabidopsis actin depolymerizing factor7 severs actin filaments and regulates actin cable turnover to promote normal pollen tube growth. Plant Cell, 2013, 25:3405-3423

18. Qu X, Zhang H, Xie Y, Wang J, Chen N and Huang S*. Arabidopsis villins promote actin turnover at pollen tube tips and facilitate the construction of actin collars. Plant Cell, 2013, 25:1803-17

19. Shi M, Xie Y, Zheng Y, Wang J, Su Y, Yang Q and Huang S*. Oryza sativa actin-interacting protein 1 is required for rice growth via promoting actin turnover. Plant J. , 2013, 73, 747-760

20. Bao C, Wang J, Zhang R, Zhang B, Zhang H, Zhou Y and Huang S*. Arabidopsis VILLIN2 and VILLIN3 act redundantly in sclerenchyma development via bundling of actin filaments. Plant J. , 2012,71: 962-975

21. Yang W, Ren S, Zhang X, Gao M, Ye S, Qi Y, Zheng Y, Wang J, Zeng L, Qun Li, Huang S*, and He Z*. BENT UPPERMOST INTERNODE1 encodes the class II formin FH5 crucial for actin organization and rice development. Plant Cell, 2011, 23:661-80=

22. Wu Y, Yan J, Zhang R, Qu X, Ren S, Chen N and Huang S* . Arabidopsis FIMBRIN5, an actin bundling factor, is required for pollen germination and pollen tube growth. Plant Cell, 2010, 22: 3745-3763

23. Zhang H, Qu X, Bao C, Khurana P, Wang Q, Xie Y, Zheng Y, Chen N, Blanchoin L, Staiger C.J and Huang S* . Arabidopsis VILLIN5, an actin filament bundling and severing protein, is required for normal pollen tube growth. Plant Cell, 2010, 22: 2749-2767

24. Ye J, Zheng Y, Yan A, Chen N, Wang Z, Huang S* and Yang Z*. Arabidopsis formin3 directs the formation of actin cables and polarized growth in pollen tubes. Plant Cell, 2009, 21:3868–3884

25. Thomas S#, Huang S#, Li S, Staiger CJ and Franklin-Tong VE. Actin depolymerization is sufficient to induce programmed cell death in self-incompatible pollen. J. Cell. Biol., 2006, 174, 221-229 (featured as an “In this issue” article, #co-first authors)

26. Huang S, Gao L, Blanchoin L and Staiger CJ. Heterodimeric capping Protein from Arabidopsis is regulated by phosphatidic acid. Mol. Biol. Cell, 2006, 17, 1946-1958

27. Huang S, Robinson RC, Gao LY, Matsumoto T, Brunet A, Blanchoin L and Staiger CJ. Arabidopsis VILLIN1 generates actin filament cables that are resistant to depolymerization. Plant Cell, 2005, 17, 486-501

28. Michelot A#, Guerin C#, Huang S#, Ingouff M, Richard S, Rodiuc N, Staiger CJ and Blanchoin L. The formin homology 1 domain modulates the nucleation and bundling activity of Arabidopsis FORMIN1. Plant Cell, 2005, 17, 2296-2313 (#co-first authors)

29. Huang S, Blanchoin L, Chaudhry F, Franklin-Tong VE and Staiger CJ. A gelsolin-like protein from Papaver rhoeas pollen stimulates calcium-regulated actin severing and depolymerization. J. Biol. Chem. , 2004, 279, 23364-23375 (cover story)

30. Huang S, Blanchoin L, Kovar DR and Staiger CJ. Arabidopsis capping protein (AtCP) is a heterodimer that regulates assembly at the barbed ends of actin filaments. J. Biol. Chem., 2003, 278, 44832-44842

●  联系方式:


电话:+86-10-62781946
E-mail:sjhuang@tsinghua.edu.cn