钟毅 博士

教授


教育经历:
1978-1982年,清华大学工程物理系               学士
1982-1985年,清华大学生物科学与技术系     硕士
1985-1991年,美国爱荷华大学生物科学系     博士

工作经历:
1991-1992年,美国爱荷华大学生物科学系      博士后
1992-1997年,美国冷泉港实验室                   助理教授
1997-2004年,美国冷泉港实验室                   副教授
2004-2013年,美国冷泉港实验室                   教授
2001-2013年,清华大学生命科学学院            兼职教授
2013年至今,清华大学生命科学学院               教授


●  研究兴趣、领域:

综合利用果蝇和小鼠等模式生物的研究优势,探究学习、记忆和遗忘的生物学机制。在此基础上,一方面致力于推进人类记忆相关疾病病理机制的研究和潜在治疗药物的开发,另一方面致力于理解生物智能的深层机理并为人工智能的研究提供启发。

●  代表性论文:


Lv, L., Liu, Y., Xie, J., Wu, Y., Zhao, J., Li, Q., and Zhong, Y*. (2019). Interplay between alpha2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory. Nature communications 10, 5313.
Zhao, B., Sun, J., Zhang, X., Mo, H., Niu, Y., Li, Q., Wang, L., and Zhong, Y*. (2019). Long-term memory is formed immediately without the need for protein synthesis-dependent consolidation in Drosophila. Nature communications 10, 4550.
Gao, Y., Shuai, Y., Zhang, X., Peng, Y., Wang, L., He, J., Zhong, Y*., and Li, Q*. (2019). Genetic dissection of active forgetting in labile and consolidated memories in Drosophila. Proc Natl Acad Sci U S A 116, 21191-21197.
Zhang, X., Li, Q.*, Wang, L., Liu, Z. J., and Zhong, Y*. (2018). Active Protection: Learning-Activated Raf/MAPK Activity Protects Labile Memory from Rac1-Independent Forgetting. Neuron 98, 142-155 e144.
Davis, R. L.*, and Zhong, Y*. (2017). The Biology of Forgetting-A Perspective. Neuron 95, 490-503.
Liu Y, Du S, Lv L, Lei B, Shi W, Tang Y, Wang L, and Zhong Y*. Hippocampal Activation of Rac1 Regulates the Forgetting of Object Recognition Memory. Current Biology, 2016, 26, 2351-2357.
Zhang X, Li Q, Wang L, Liu ZJ, and Zhong Y*. Cdc42-Dependent Forgetting Regulates Repetition Effect in Prolonging Memory Retention. Cell Reports, 2016, 16, 817-825.
Dong T, He J, Wang S, Wang L, Cheng Y, and Zhong Y*. Inability to activate Rac1-dependent forgetting contributes to behavioral inflexibility in mutants of multiple autism-risk genes. Proc Natl Acad Sci U S A, 2016, 113, 7644-7649.
Wang L, Chiang HC, Wu W, Liang B, Xie Z, Yao X, Ma W, Du S, and Zhong Y*. Epidermal growth factor receptor is a preferred target for treating amyloid-beta-induced memory loss. Proc Natl Acad Sci U S A, 2012, 109, 16743-16748.
Shao L, Shuai Y, Wang J, Feng S, Lu B, Li Z, Zhao Y, Wang L, and Zhong Y*. Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila. Proc Natl Acad Sci U S A, 2011, 108, 18831-18836.
 Shuai YC, Lu BY, Hu Y, Wang LZ, Sun K, and Zhong Y*. Forgetting Is Regulated through Rac Activity in Drosophila. Cell, 2010, 140, 579-589.
 Pagani MR, Oishi K, Gelb BD, and Zhong Y*. The Phosphatase SHP2 Regulates the Spacing Effect for Long-Term Memory Induction. Cell, 2009, 139, 186-198.

●  荣誉、奖励及参加学术团体的情况:


1994- 1997年,“Pew”生物医学优秀学者奖
2001年教育部“长江学者奖励计划”讲座教授


 

●  联系方式:


电话:010-62772273
E-mail:zhongyithu@tsinghua.edu.cn