Jose C. PASTOR-PAREJA

研究员


1999  西班牙阿利坎特大学,获生物学学士学位

2004  西班牙马德里自治大学,获分子生物学博士学位

2005-2011  美国耶鲁大学 遗传系,博士后

2011-2012  美国耶鲁大学 遗传系,副研究员

2012-   清华大学生命科学学院,PI


●  研究兴趣、领域:


我们了解生物机体的一个主要的障碍是其在组织水平上的复杂性。基膜(basement membranes,BMs)是由高度保守的细胞外基质蛋白的聚合物,它与其组分为所有动物组织都提供了必要的结构性支持。在细胞的形态发生,细胞信号,免疫反应,细胞再生和肿瘤形成的过程中,基膜与其组分都起着关键的作用。我们在最近的研究中发现,基膜的两个重要的组成成分IV型胶原蛋白(Collagen IV)和串珠素(Perlecan),发挥相反的作用力来决定细胞和器官的形状。目前本实验室正在进行的几个项目,研究的就是基底膜各组分如何分泌并组装成多聚体及其在发育、再生和癌症中的作用。

 

●  代表性论文:


1. Atypical basement membranes and basement membrane diversity: what is normal, anyway?
Pastor-Pareja JC*.
J Cell Sci (2020) (Review) (in press)
2. Spectraplakin Shot maintains perinuclear microtubule organization in Drosophila polyploid cells.
Sun T, Song Y, Dai J, Mao D, Ma M, Ni J-Q, Liang X, Pastor-Pareja JC*.
Dev Cell (2019) 49:1-7.
3. Dissection of Nidogen function in Drosophila reveals tissue-specific mechanisms of basement membrane assembly.
Dai J, Estrada B, Jacobs S, Sanchez-Sanchez-B, Tang J, Ma M, Pastor-Pareja JC*, Martin-Bermudo MD*.
PLoS Genet (2018) 14(9):e1007483.
4. Collagen secretion screening in Drosophila supports a common secretory machinery and multiple Rab requirement.
Ke H, Feng Z, Liu M, Sun T, Dai J, Ma M, Liu L-P, Ni J-Q, Pastor-Pareja JC*.
J Genet Genom (2018) 45:299-313.
5. The Ultrabithorax Drosophila Hox gene controls appendage shape by regulating extracellular matrix dynamics.
de las Heras J, García-Cortés C, Foronda D, Pastor-Pareja JC, Shashidhara LS, Sánchez-Herrero E.
Development (2018) 145:dev161844.
6. Inter-adipocyte adhesion and signaling by Collagen IV concentrations in Drosophila.
Dai J, Ma M, Feng Z, Pastor-Pareja JC*.
Curr Biol (2017) 27:1-12. 
7. Basement membrane manipulation in Drosophila wing discs affects Dpp retention but not growth mechanoregulation.
Ma M, Cao, Dai J, Pastor-Pareja JC*.
Dev Cell (2017) 42:97-106.
8. Tango1 spatially organizes ER exit sites to control ER export.
Liu M#, Feng Z#, Ke H, Liu Y, Sun T, Dai J, Cui W, Pastor-Pareja JC*.
J Cell Biol (2017) 216:1035-59.
9. Extracellular chloride signals Collagen IV network assembly to form basement membranes outside cells. Cummings CF, Pedchenko V, Brown KL, Colon S, Rafi M, Stothers C, Ero-Tolliver IA, Jones-Paris C, Pokydeshava E, Liu M, Pastor-Pareja JC, McCall AS, Vanacore R, Gautam Bhave G, Santoro S, Blackwell T, Zent R, Pozzi A, Hudson BG.
J Cell Biol (2016) 213:479-494.
10. Localized JNK signaling regulates organ size during development.
Willsey HR, Zheng X, Pastor-Pareja JC, Willsey AJ, Beachy PA, Xu T.
eLIFE (2016) 10.7554/eLife.11491.
11. Plasma membrane overgrowth causes fibrotic collagen accumulation and immune activation in Drosophila adipocytes.
Zang Y#, Wan M#, Liu M, Ke H, Ma S, Liu LP, Ni JQ, Pastor-Pareja JC*.
eLIFE (2015) 10.7554/eLife.07187.
12. Toll pathway modulates TNF-induced JNK-dependent cell death in Drosophila.
Wu C, Chen C, Dai JL, Zhang F, Chen Y, Li W, Pastor-Pareja JC, Xue L.
Open Biol (2015) 10.1098/rsob.140171.
13. Dissecting social cell biology and tumors using Drosophila genetics.
Pastor-Pareja JC*, Xu T*.
Ann Rev Genet (2013) 47:51-74. (Review)

●  联系方式:


通讯地址:清华大学医学科学楼D224,北京 100084
电话:010-62783498(办公室)  010-62783597(实验室)
邮箱:josepastor@tsinghua.edu.cn
网址:http://joselab.life.tsinghua.edu.cn