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07-20:Molecular Mechanisms of Islet Cell Compensation and Decompensation Under Metabolic Stress

Seminar

TopicMolecular Mechanisms of Islet Cell Compensation and Decompensation Under Metabolic Stress

Abstract: As principal players in maintaining glucose homeostasis, the α and β cells of pancreatic islet have intrinsic ability to adapt to changing metabolic demand. One form of adaptation for both cell types is changing cell number. The adaptability and its sustainability of β-cells are critical determinants of type 2 diabetes susceptibility, but the physiological significance of α-cell adaptability is unknown. The underlying molecular mechanisms of the adaptation (commonly known as compensation) are not fully understood. We have generated zebrafish models of α and β cell compensation in order to elucidate the molecular underpinnings. I will discuss our recent findings on the role of FGF1 in mediating overnutrition-induced β-cell differentiation, as well as islet inflammation in overnutrition-induced β-cell death. I will also discuss our recent discovery of a hepatocyte- α cells axis in regulation of blood amino acids, and the mechanism of hyperaminoacidemia-induced α cell proliferation.

SpeakerDr. Wenbiao Chen

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine

Time16:00 pm. July 20, 2017 (Thursday)

VenueMedical Science Building B321

HostDr. Anming Meng

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