教职员工
兼职教授
讲席教授
杰出人才
其他获奖
谷杨楠

谷杨楠 博士

助理教授 研究员 博士生导师

 

教育工作经历

 

2003-2007年,西安交通大学   生物工程 学士

2007-2013年,美国印第安纳大学   分子细胞发育生物学 博士

2011-2013年,美国印第安纳大学   应用统计学 硕士

2013-2015年,美国杜克大学-霍华德休斯医学院   博士后

2015-2017年,美国杜克大学-霍华德休斯医学院   高级研究助理

2017年至今, 清华大学生命科学学院, 清华-北大联合生命科学中心   助理教授,研究员,博士生导师

 

主要研究方向

 

植物在与微生物长达几亿年的共存互作过程中演化出了极其复杂和精密的免疫系统。有别于具有专职免疫细胞的动物,植物的每一个细胞都可以启动免疫反应,甚至可以精确地调用和改变细胞的其他生理过程来实现多样化的免疫结果,是一个具有高度研究价值的系统。

 

本实验室致力于研究植物的免疫调控机制。我们利用分子,细胞,遗传,生化,生统,生物信息学等综合手段主攻此过程中免疫分子和信号是如何利用细胞内膜转运系统以及核质穿梭来启动,控制和终止抗病反应的。我们同时也关注细胞核膜上的大分子复合体(如核孔复合体)以及全新的跨膜蛋白对植物细胞免疫的调控作用。

 

代表性论文

1. Gu, Y. (2017). Nuclear pore complex: a strategic platform for regulating cell signaling New Phytologist (Tansley Insight) DOI-10.1111/nph.1475.

2. Gu, Y.*, Zavaliev, R and Dong, X. (2017). Membrane trafficking in plant immunity. Molecular Plant 10: 1026-1034. *Corresponding author

3. Gu, Y., Zebell, S., Liang, Z., Wang, S., Kang, B. and Dong, X. (2016). Nuclear pore permeabilization is a convergent signaling event in effector-triggered immunity. Cell 166: 1526-1538.

    •   Highlighted by commentary "Gating immunity and death at the nuclear pore complex", Cell (2016) 166: 1364-1366.

4. Liu, L., Sonbol, FM., Huot, B., Gu, Y., Withers, J., Mwimba, M., Yao, J., He, S.Y. and Dong, X. (2016). Salicylic acid receptors activate jasmonic acid signalling through a noncanonical pathway to promote effector-triggered immunity; Nature Communications 7: 13099.

5. Gu, Y. and Dong X. (2015). Stromules: signal conduits for plant immunity. Developmental Cell 34: 3-4.

6. Saleh, A., Withers, J., Mohan, R., Marques, J., Gu, Y., Yan, S., Zavaliev, R., Nomoto, M., Tada, Y. and Dong, X. (2015). Posttranslational modifications of the master transcriptional regulator NPR1 enable dynamic but tight control of plant immune responses; Cell Host-Microbe 18: 169-182.

7. Pauwels, L., Ritter, A., Goossens, J., Durand, A.N., Liu, H., Gu, Y., Geerinck, J., Boter, M., Bossche, R.V., De Clercq, R., Van Leene, J., Gevaert, K., De Jaeger, G., Solano, R., Stone, S., Innes, R.W., Callis, J. and Goossens, A. (2015). The RING E3 ligase KEEP ON GOING modulates Jasmonate ZIM-domain 12 stability. Plant Physiology 169: 1405-1417.

8. Wang, S.#, Gu, Y.#, Zebell, S.#, Anderson, L.K., Wang, W., Mohan, R., and Dong, X. (2014). A noncanonical role for the CKI-RB-E2F cell-cycle signaling pathway in plant effector-triggered immunity. Cell Host-Microbe 16: 787-794. #Co-first authorship.

   •  Highlighted by commentary "Co-opting the cell-cycle machinery for plant immunity", Cell Host-Microbe (2014) 16: 707-709.

9. Serrano, I.#, Gu, Y.#, Qi, D., Dubiella, U. and Innes, R.W. (2014). The Arabidopsis EDR1 protein kinase negatively regulates the ATL1 E3 ubiquitin ligase to suppress cell death. Plant Cell 26: 4532-4546. #Co-first authorship. 


10. Gu, Y. and Innes, R.W. (2012). The Keep On Going (KEG) protein of Arabidopsis regulates intracellular protein trafficking and is degraded during fungal infection. Plant Cell 24: 4717-4730.

•  Highlighted by research spotlight, IS-MPMI Reporter (2013) 1: 7

11.  Gu, Y. and Innes, R.W. (2011). The Keep On Going (KEG) protein of Arabidopsis physically interacts with the Enhanced Disease Resistance 1 (EDR1) protein and recruits it to early endosomes; Plant Physiology 115: 1827-1838.

12.  Christiansen, K.M., Gu, Y., Rodibaugh, N.L. and Innes R.W. (2011). Negative regulation of defense signaling pathways by the EDR1 protein kinase. Molecular Plant Pathology 12: 746–758.

联系方式

 

办公室:清华大学生物技术馆4111

Email: ygu@tsinghua.edu.cn

     gulab@biomed.tsinghua.edu.cn

实验室电话:010-62793181

办公室电话:010-62793182

 

 
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