教职员工
兼职教授
讲席教授
杰出人才
其他获奖
杨茂君

杨茂君 博士

教授、博导

 

1995-1999    吉林大学,学士

1999-2003  中国协和医科大学,博士

2003-2004    德国吕贝克大学,高级访问学者

2004-2008    美国西南医学中心,博士后

2008-至今     清华大学生命科学学院,教授、博导

 

主要科研领域与方向:

本实验室主要围绕与传染病、癌症等人类重大疾病发生息息相关的膜蛋白和可溶性蛋白进行结构与功能研究,以及以这些蛋白质结构为基础的小分子化合物的筛选及设计。近年来主要在线粒体相关蛋白的结构与机制,蛋白质泛素化调控两个方面得到了部分研究成果。

 

代表性论文:

1.    Yang Y, Yu Y, Li X, Li J, Wu Y, Yu J, Ge J, Huang Z, Jiang L*, Rao Y*, Yang M*. Target Elucidation by Co-crystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium Falciparum (PfNDH2) with Small Molecule to Eliminate Drug-Resistant Malaria. J Med Chem. 2017 Mar 9;60(5):1994-2005.

2.    Wu K, Li W, Yu L, Tong W, Feng Y, Ling S, Zhang L, Zheng X*, Yang M*, Tian C*. Temperature-dependent ESR and computational studies on antiferromagnetic electron transfer in the yeast NADH dehydrogenase Ndi1. Phys Chem Chem Phys. 2017 Feb 8;19(6):4849-4854.

3.    Wu M, Gu J, Guo R, Huang Y, Yang M*. Structure of mammalian respiratory supercomplex I1III2IV1. Cell. 2016, Dec 1. 2016 Dec 01; 167(6):1598-1609.e10.

4.    Gu J, Wu M, Guo R, Yan K, Lei J, Gao N*, Yang M*. The architecture of the mammalian respirasome. Nature. 2016 Sep 21;537(7622):639-43.

5.    Wang QC, Zheng Q, Tan H, Zhang B, Li X, Yang Y, Yu J, Liu Y, Chai H, Wang X, Sun Z, Wang JQ, Zhu S, Wang F, Yang M, Guo C, Wang H, Zheng Q, Li Y, Chen Q, Zhou A, Tang TS. TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel. Cell. 2016 Jun 2;165(6):1454-66.

6.    Zhang C, Hao H, Yu Y, Kong D, Chen S, Jiang H, Yuan Y, Zheng Y, Yang M*, Jiang Y*. Structural basis of the interaction between the meningitis pathogen Streptococcus suis adhesin Fhb and its human receptor. FEBS Lett. 2016 May;590(9):1384-92.

7.    Ge J, Li W, Zhao Q, Li N, Cheng M, Zhi P, Li R, Gao N*, Xiao B*, Yang M*. Architecture of the Mammalian Mechanosensitive Piezo1 Channel. Nature. 2015. Nov 5;527(7576):64-9. (Article)

8.    Li N, Zhai Y, Zhang Y, Li W, Yang M, Lei J, Tye BK, Gao N. Structure of the eukaryotic MCM complex at 3.8 Å. Nature. 2015 Aug 13;524(7564):186-91.

9.    Yu J, Pian Y, Ge J, Guo J, Zheng Y, Jiang H, Hao H, Yuan Y, Jiang Y*, Yang M*. Functional and Structural Characterization of the Antiphagocytic Properties of a Novel Transglutaminase from Streptococcus suis. J Biol Chem. 2015 Jul 31;290(31):19081-92.

10.  Yu J, Ge J, Heuveling J, Schneider E*, Yang M*. Structural basis for substrate specificity of an amino acid ABC transporter. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5243-8.

11.  Li Y, Zhang L, Liu T, Chai C, Fang Q, Wu H, Paula Garcia, Han Z, Zong S, Yu Y, Zhang X, Parthun M, Chai J, Xu R and Yang M*. Hat2p recognizes histone H3 tail to specify the acetylation of newly-synthesized H3/H4 heterodimer by Hat1p/Hat2p complex. Genes & Development. 2014 Jun 1;28(11):1217-27.

12.  Li Y, Wu W, Wu H, Zhuo W, Liu W, Zhang Y, Cheng M, Chen Y, Gao N, Yu H, Wang L, Li W and Yang M*. Structural insight into the TRIM family of ubiquitin E3 ligases. Cell Research.2014 Jun;24(6):762-5.

13.  Guo Y, Dong L, Qiu X, Wang Y, Zhang B, Liu H, Yu Y, Zang Y, Yang M, Huang Z. Structural basis for hijacking CBFβ and CUL5 E3 ligase complex by HIV-1 Vif. Nature. 2014 Jan 9;505(7482):229-33.

14.  Yu Y, Zhou M, Kirsch F, Xu C, Zhang L, Wang Y, Jiang Z, Wang N, Li J, Eitinger T, Yang M*. Planar substrate binding site dictates the specificity of ECF-type nickel/cobalt transporters. Cell Research. 2014 Mar;24(3):267-77.

15.  Zhang Y, Zhao H, Wang J, Ge J, Li Y, Gu J, Li P, Feng Y, Yang M*. Structural insight into Caenorhabditis elegans sex-determining protein FEM-2. J Biol Chem. 2013 Jul 26;288(30):22058-66.

16.  Sun Z, Gong J, Wu H, Xu W, Wu L, Xu D, Gao J, Wu JW, Yang H, Yang M, Li P. Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes. Nat Commun. 2013;4:1594.

17.  Feng Y, Li W, Li J, Wang J, Ge J, Xu D, Liu Y, Wu K, Zeng Q, Wu JW, Tian C, Zhou B, Yang M*. Structural insight into the type-II mitochondrial NADH dehydrogenases. Nature. 2012 Nov 15;491(7424):478-82.

18.  Zhang X, Wang J, Feng Y, Ge J, Li W, Sun W, Iscla I, Yu J, Blount P, Li Y*, Yang M*. Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18180-5.

19.  Xiang H, Feng Y, Wang J, Liu B, Chen Y, Liu L, Deng X*, Yang M*. Crystal structures reveal the multi-ligand binding mechanism of Staphylococcus aureus ClfB. PLoS Pathog. 2012;8(6):e1002751.

20.  She J, Han Z, Kim TW, Wang J, Cheng W, Chang J, Shi S, Wang J, Yang M, Wang ZY, Chai J. Structural insight into brassinosteroid perception by BRI1. Nature. 2011 Jun 12;474(7352):472-6.

21.  Zhang JH, Ge L, Qi W, Zhang L, Miao HH, Li BL, Yang M, Song BL. The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake. J Biol Chem. 2011 Jul 15;286(28):25088-97.

22.  Doyle JM, Gao J, Wang J, Yang M*, Potts PR*. MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Mol Cell. 2010 Sep 24;39(6):963-74.

 

联系方式:

电话:+86-10-62792606(实验室)

E-mail: maojunyang@mail.tsinghua.edu.cn

 

 
版权所有©清华大学生命科学学院 地址:北京市海淀区清华园 邮政编码:100084
电话:+86-10-62772269 传真:+86-10-62788604 电子邮箱:swxrs@tsinghua.edu.cn