教职员工
兼职教授
讲席教授
杰出人才
其他获奖
隋森芳

隋森芳 博士

教授,博士生导师

 

简历

1964-1970      清华大学精密仪器系系,学士

1978-1981      清华大学工程物理系,硕士

1985-1988      德国慕尼黑工业大学生物物理所,博士

1989-1991      清华大学生物科学与技术系,副教授

1991.1-至今    清华大学生命科学学院(2009年9月以前为生物科学与技术系),教授、博导

2009年当选中国科学院院士

 

主要科研领域和研究方向

我们利用冷冻电子显微学,结合生物化学、生物物理学和细胞生物学等技术手段,研究(1)蛋白质复合体及复杂蛋白质机器的结构、功能与工作机理;(2)膜蛋白的结构、功能与工作机理;(3)囊泡运输中的分子机制,蛋白质与膜脂的相互作用,生物膜与重大疾病的关系。

 

代表性论文

 

1. Zhang, J., Pan, X., Yan, K., Sun, S., Gao, N.*, Sui, S.F.* (2015) Mechanisms of ribosome stalling by SecM at multiple elongation steps. Elife 4, pii: e09684.

 

2. Hu, Z., Zhou, Q., Zhang, C., Fan, S., Cheng, W., Zhao, Y., Shao, F., Wang, H.W., Sui, S.F.*, Chai, J.* (2015). Structural and biochemical basis for induced self-propagation of NLRC4. Science 350, 399-404.

 

3. Chang, L., Liu, X., Li, Y., Liu, C.C., Yang, F., Zhao, J.*, Sui, S.F.* (2015) Structural organization of an intact phycobilisome and its association with photosystem II. Cell Research 25, 726-737.

 

4. Zhou, Q., Huang, X., Sun, S., Li, X., Wang, H.W.*, Sui, S.F.* (2015). Cryo-EM structure of SNAP-SNARE assembly in 20S particle. Cell Research 25, 551-560.

 

5. Li, B., Wang, Q., Pan, X., Fernández de Castro I., Sun, Y., Guo, Y., Tao, X., Risco, C., Sui, S.F., Lou, Z.* (2013) Bunyamwera virus possesses a distinct nucleocapsid protein to facilitate genome encapsidation. Proc. Natl. Acad. Sci. U. S. A. 110, 9048-9053.

 

6. Chang, L.F., Chen, S., Liu, C.C., Pan, X., Jiang, J., Bai, X.C., Xie, X., Wang, H.W., Sui, S.F.* (2012) Structural characterization of full-length NSF and 20S particles. Nat. Struct. Mol. Biol. 19, 268-275.

 

7. Liu, L., Feng, D., Chen, G., Chen, M., Zheng, Q., Song, P., Ma, Q., Zhu, C., Wang, R., Qi, W., Huang, L., Xue, P., Li, B., Wang, X., Jin, H., Wang, J., Yang, F., Liu, P., Zhu, Y., Sui, S.F., Chen Q.* (2012) Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat. Cell Biol. 14, 177-185.

 

8. Bai, X.C., Pan, X.J., Wang, X.J., Ye, Y.Y., Chang, L.F., Leng, D., Lei, J., Sui, S.F.* (2011) Characterization of the structure and function of Escherichia coli DegQ as a representative of the DegQ-like proteases of bacterial HtrA family proteins. Structure 19, 1328–1337.

 

9. Liu, R.Q., Zhou, Q.H., Ji, S.R., Zhou, Q., Feng, D., Wu, Y., Sui, S.F. (2010) Membrane localization of beta-amyloid 1-42 in lysosomes: a possible mechanism for lysosome labilization. J. Biol. Chem. 285, 19986–19996.

 

10. Feng, D., Zhao, W.L., Ye, Y.Y., Bai, X.C., Liu, R.Q., Chang, L.F., Zhou, Q., Sui, S.F.* (2010) Cellular internalization of exosomes occurs through phagocytosis. Traffic 11, 675–687.

 

11. Shen, Q.T., Bai, X.C., Chang, L.F., Wu, Y., Wang, H.W., Sui, S.F.* (2009) Bowl-shaped oligomeric structures on membranes as DegP’s new functional forms in protein quality control. Proc. Natl. Acad. Sci. U. S. A. 106, 4858–4863.

 

12. Jiang, J., Zhang, X., Chen, Y., Wu, Y., Zhou, Z.H., Chang, Z.*, Sui, S.F.* (2008) Activation of DegP Chaperone-Protease via Formation of Large Cage-like Oligomers Upon Binding to Substrate Proteins. Proc. Natl. Acad. Sci. U. S. A. 105, 11939-11944.

 

13. Chen, Y., Pan, X., Tang, Y., Quan, S., Tai, P.C., Sui, S.F.* (2008) Full length E.coli SecA dimerizes in a closed conformation in solution as determined by cryo- electron microscopy. J. Biol. Chem. 283, 28783-28787.

 

联系方式
电话:+86-10-62792083

传真:+86-10-627933674

E-mail: suisf@mail.tsinghua.edu.cn

Web: http://suilab.life.tsinghua.edu.cn/

 
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