教职员工
兼职教授
讲席教授
杰出人才
其他获奖
熊巍

熊巍

研究员,博士生导师

 

教育和工作经历

1999    武汉大学生命科学学院        学士

2006    中科院神经科学研究所        博士

2006-2007       北京大学分子医学研究所    研究助理

2007-2014       The Scripps Research Institute           Postdoc/Staff Scientist

2015.1至今    清华大学生命科学学院        研究员,博士生导师

 

主要研究领域与方向

听觉形成的生物学机制及相关疾病(耳聋)的致病机理。

 

近期代表论文

1.        Beurg, M., W. Xiong, B. Zhao, U. Muller, and R. Fettiplace. "Subunit Determination of the Conductance of Hair-Cell Mechanotransducer Channels." Proc Natl Acad Sci U S A, no. 112 (2015): 1589-1594.

2.        Xiong, W.*, T. Wagner, L. Yan, N. Grillet, and U. Muller.* "Using Injectoporation to Deliver Genes to Mechanosensory Hair Cells." Nat Protoc 9, no. 10 (2014): 2438-49.

3.        Shang, S., C. Wang, B. Liu, Q. Wu, Q. Zhang, W. Liu, L. Zheng, H. Xu, X. Kang, X. Zhang, Y. Wang, H. Zheng, S. Wang, W. Xiong*, T. Liu*, and Z. Zhou*. "Extracellular Ca(2)(+) Per Se Inhibits Quantal Size of Catecholamine Release in Adrenal Slice Chromaffin Cells." Cell Calcium 56, no. 3 (2014): 202-7.

4.        Zheng, L., Wang, C., Shang, S., Zhang, X., Wang, Y., Wu, Q., Hu, M., Chai, Z., Wu, X., Zheng, H., Zhang, C., Wang, L.*, Xiong, W. *, and Zhou, Z. * “Real-time endocytosis imaging as a rapid assay of ligand-GPCR binding in single cells,” Am J Physiol Cell Physiol 305, no. 7 (2013): p. 751-60. (#, Co-correspondence author)

5.        Xiong, W., Grillet, N., Elledge, H. M., Wagner, T. F.J., Zhao, B., Johnson, K. R., Kazmierczak, P. and Müller, U., “TMHS is an Integral Component of the Mechanotransduction Machinery of Cochlear Hair Cells,” Cell 151, no. 6 (2012): p. 1283-95. (Reviewed by Faculty of 1000 [F1000Prime.com/717967202])

6.        Xiong, W.#, Liu, T.#, Wang, Y., Chen, X., Sun, L., Guo, N., Zheng, H., Zheng, L., Ruat, M., Han, W., Zhang, C. X. and Zhou, Z., "An Inhibitory Effect of Extracellular Ca on Ca-Dependent Exocytosis," PLoS One 6, no. 10 (2011): e24573. (* Co-first author)

7.        Grillet, N.#, Xiong, W.#, Reynolds, A.#, Kazmierczak, P., Sato, T., Lillo, C., Dumont, R. A., Hintermann, E., Sczaniecka, A., Schwander, M., Williams, D., Kachar, B., Gillespie, P. G. and Müller, U., "Harmonin Mutations Cause Mechanotransduction Defects in Cochlear Hair Cells," Neuron 62, no. 3 (2009): 375-387. Featured in Neuron Previews in the same issue)

8.        Schwander, M., Xiong, W., Tokita, J., Lelli, A., Elledge, H. M., Kazmierczak, P., Sczaniecka, A., Kolatkar, A., Wiltshire, T., Kuhn, P., Holt, J. R., Kachar, B., Tarantino, L. and Müller, U., "A Mouse Model for Nonsyndromic Deafness (Dfnb12) Links Hearing Loss to Defects in Tip Links of Mechanosensory Hair Cells," Proc Natl Acad Sci U S A 106, no. 13 (2009): 5252-5257. (Featured in Proc Natl Acad Sci U S A Commentary in the same issue)

9.        Wang, L. C.#, Xiong, W.#, Zheng, J., Zhou, Y., Zheng, H., Zhang, C., Zheng, L. H., Zhu, X. L., Xiong, Z. Q., Wang, L. Y., Cheng, H. P. and Zhou, Z., "The Timing of Endocytosis after Activation of a G-Protein-Coupled Receptor in a Sensory Neuron," Biophys J 90, no. 10 (2006): 3590-3598.

10.    Zhang, C.#, Xiong, W.#, Zheng, H., Wang, L., Lu, B. and Zhou, Z., "Calcium- and Dynamin-Independent Endocytosis in Dorsal Root Ganglion Neurons," Neuron 42, no. 2 (2004): 225-236. 

 

联系方式

医学科学楼B216

清华大学生命科学学院

北京100084

电话: +86-10-62792464

Email: wei_xiong@mail.tsinghua.edu.cn

实验室网站:neurocomlab.org

 
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