教职员工
兼职教授
讲席教授
杰出人才
其他获奖
薛定

薛定 博士

教授,长江讲座教授,千人计划专家

工作经历:

1981-1986年,  中国科技大学生物系                           学士

1986-1987年,  中国科学院上海细胞生物学研究所          研究生

1988-1989年,     美国康涅狄格大学医学院                          研究生

1989-1993年,  美国哥伦比亚大学生命科学系                  发育生物学博士

1994-1997年,  美国麻省理工学院大学生物系               博士后

1997年至今,   美国科罗拉多大学波德分校,                  助理教授、副教授(tenured)、教授

2007-2013年, 清华大学生命学院                                   讲席教授

2013年至今      清华大学生命学院                                   教授,博士生导师,“千人计划” 专家

2008-2014,       瑞典卡罗琳斯卡医学院                              外籍教授

主要科研领域与方向:

以秀丽线虫为主要动物模型,研究细胞凋亡的调控机制,磷酸脂在生物膜上不对称分布的调控机制,父本线粒体在早期胚胎发育过程中选择性清除的分子机制,乙型肝炎病毒致病的机制和筛药,以及由非正常的细胞凋亡及磷酸脂不对称分布引起的疾病,如癌症,自身免疫疾病等。

代表性文献:

  • Parrish, J., Li, L., Klotz, K., Ledwich, D., Wang, X.D., and Xue, D. (2001).  Mitochondrial endonuclease G is important for apoptosis in C. elegansNature 412, 90-94.
  • Wang, X.C., Yang, C.L., Cai, J.J., Shi, Y.G., and Xue, D. (2002).  Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegansScience 298, 1587-1592. (Research Article)
  • Parrish, J. and Xue, D. (2003). Functional genomic analysis of apoptotic DNA degradation in C. elegansMolecular Cell 11, 987-996.
  • Wang, X.C, Wu, Y.C, Fadok, V., Lee, M.C., Gengyo-Ando, K., Cheng, L.C., Ledwich, D., Hsu, P.K., Chen, J.Y., Chou, B.K., Henson, P., Mitani, S., and Xue, D. (2003).  Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12.  Science 302, 1563-1566.
  • Kokel, D., Li, Y.H., Qin, J., and Xue, D. (2006). The non-genotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in C. elegans.  Nature Chemical Biology 2: 338-345.
  • Wang, X.C., Wang, J., Yang, C.L, Gengyo-Ando, K., Gu, L.C., Sun, C.L., Shi, Y., Shi, Y.G., Mitani, S., Xie, X.S., and Xue, D. (2007). "C. elegans Mitochondrial Factor WAH-1 Promotes Phosphatidylserine Externalization in Apoptotic Cells by Activating Phospholipid Scramblase 1".  Nature Cell Biology 9, 541-549.
  • Peden, E., Kimberly, E.L., Gengyo-Ando, K., Mitani, S., and Xue, D. (2007). Control of sex-specific apoptosis in C. elegans by the BarH homeodomain protein CEH-30 and the transcriptional repressor UNC-37/Groucho. Genes & Development 21, 2195-3207.
  • Darland-Ransom, M., Wang, X.C., Sun, C.L., Mapes, J., Gengyo-Ando, K., Mitani, S. and Xue, D.* (2008). Role of the C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. Science 320, 528-531.
  • Breckenridge, D., Kang, B.H., Kokel, D., Mitani, S., Staehelin, A.L., and Xue, D.* (2008). Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell death execution pathways downstream of ced-3 and independent of ced-9. Molecular Cell 31, 586-597.
  • Geng, X., Shi, Y., Nakagawa, A., Yoshina, S., Mitani, S., Shi, Y., and Xue, D.* (2008).  Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by a caspase homolog CSP-3. Nature Structural & Molecular Biology 15, 1094-1101.
  • Nakagawa, A., Shi, Y., Kage-Nakadai, E., Mitani, S., and Xue, D.* (2010). Caspase-Dependent Conversion of Dicer Ribonuclease into a Death-Promoting Deoxyribonuclease. Science 328, 327-334. (Research Article).
  • Wang, X.C., Li W., Zhao, D.F., Liu, B., Shi, Y., Chen, B.H., Yang, H.W., Guo, P.F., Geng, X., Shang, Z.H., Peden, E., Kage-Nakadai, E., Mitani, S., and Xue, D.* (2010). C. elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor. Nature Cell Biology 12, 655-664.
  • Zhou, Q.H., Li, H.M., and Xue, D.* (2011). Elimination of Paternal mitochondria through the lysosomal degradation pathway in C. elegans. Cell Research 21, 1662-1669.
  • Mapes, J., Chen, Y.Z., Kim, A., Mitani, S., Kang, B.H., and Xue, D.* (2012). CED-1, CED-7, and TTR-52 act in a pathway to regulate exoplasmic phosphatidylserine expression on apoptotic and phagocytic cells. Current Biology 22, 1267-1275.
  • Geng, X., Harry, B.L., Zhou, Q.H., Skeen-Gaar, R.B., Ge, X., Lee, E.S., Mitani, S., and Xue, D.* (2012a). Hepatitis B Virus X protein targets the Bcl-2 protein CED-9 to induce intracellular Ca2+ increase and cell death in C. elegans. Proc. Natl. Acad. Sci. USA 109: 18465-18470.
  • Geng, X., Huang, C.H., Qin, Y., McComb, J., Yuan, Q., Harry, B.L., Palmer, A., Xia, N.S., and Xue, D.* (2012b). Hepatitis B virus X protein targets Bcl-2 proteins to increase cytosolic Ca2+, required for virus replication and cell death induction. Proc. Natl. Acad. Sci. USA 109, 18471-18476.
  • Chen, Y.Z., Mapes, J., Lee, E.S. and Xue, D.* (2013). Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and PS externalization. Nature Communications 4:2726 doi: 10.1038/ncomms3726.
  • Zhao, P., Zhang, Z., Ke, H.M., Ye, Y.R. and Xue, D.* (2014). Oligonucleotide-based targeted gene editing in C. elegans via the CRISPR/Cas9 system. Cell Research 24: 247-250.

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