教职员工
兼职教授
讲席教授
杰出人才
其他获奖
王佳伟

个人简历
1996-2001年 就读于中国科学技术大学材料科学与工程系获学士学位;
2001-2005年 于中国科学院物理研究所攻读博士学位;
2005-2008年 于美国阿岗国家实验室/国立癌症研究所蛋白质晶体学实验室/SAIC-Frederick Inc.从事博士后研究;
2008-2011年 于清华大学生物科学与技术系任高级工程师;
2011年 受聘于清华大学生命科学学院担任助理教授。
 
研究方向
膜蛋白晶体学:利用X射线晶体学解析与重大疾病相关的膜蛋白的晶体结构,同时探索利用细聚焦光束线测定微小膜蛋白晶体结构的技术,及微小晶体衍射相位的获取和结构分析等关键科学问题。

代表性学术论文

  1. J. Davis, J. W. Wang, J. E. Tropea, D. Zhang, Z. Dauter, D. S. Waugh, A. Wlodawer (2008) Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri. Protein Science, 17, 2167-2173.
  2. J. W. Wang, M. Dauter, R. Alkire, A. Joachimiak, Z. Dauter (2007) Triclinic lysozyme at 0.65 Å resolution, Acta Cryst. D63, 1254-1268.
  3. J. W. Wang, M. Dauter, Z. Dauter (2006) What can be done with a good crystal and an accurate beamline? Acta Cryst. D62, 1475-1483.
  4. J. W. Wang, J. R. Chen, Y. X. Gu, C. D. Zheng, H. F. Fan (2004) Direct-method SAD phasing with partial-structure iteration: towards automation, Acta Cryst. D60, 1991-1996.
  5. J. W. Wang, J. R. Chen, Y. X. Gu, C. D. Zheng, F. Jiang, H. F. Fan (2004) Optimizing the error term in direct-method SAD phasing, Acta Cryst. D60, 1987-1990.
  6. J. W. Wang, J. R. Chen, Y. X. Gu, C. D. Zheng, F. Jiang, H. F. Fan, T. C. Terwilliger, Q. Hao (2004) “SAD phasing by combination of direct methods with the SOLVE/RESOLVE procedue”, Acta Cryst. D60, 1244-1253.
  7. Zhou N, Wang H*, Wang J*. EMBuilder: A Template Matching-based Automatic Model-building Program for High-resolution Cryo-Electron Microscopy Maps. Scientific reports. 2017;7:2664.
  8. Rao Q, Liu M, Tian Y, Wu Z, Hao Y, Song L, Qin Z, Ding C, Wang HW*, Wang J*, Xu Y*. Cryo-EM structure of human ATR-ATRIP complex. Cell research. 2017.
  9. Bao Z, Qi X, Hong S, Xu K, He F, Zhang M, Chen J, Chao D, Zhao W, Li D, Wang J*, Zhang P*. Structure and mechanism of a group-I cobalt energy coupling factor transporter. Cell research. 2017;27:675-87.
  10. Wang J*, Chai J, Wang H. Structure of the mouse Toll-like receptor 13 ectodomain in complex with a conserved sequence from bacterial 23S ribosomal RNA. The FEBS journal. 2016;283:1631-5 (Cover, review).
  11. Gao S, Pan M, Zheng Y, Huang Y, Zheng Q, Sun D, Lu L, Tan X, Tan X, Lan H, Wang J, Wang T, Wang J*, Liu L*. Monomer/Oligomer Quasi-Racemic Protein Crystallography. Journal of the American Chemical Society. 2016;138:14497-502.
  12. Wang J, Wang W, Song W, Han Z, Zhang H, Chai J*, Wang H*, Wang J*. An improved method for phasing crystal structures with low non-crystallographic symmetry using cryo-electron microscopy data. Protein & cell. 2015;6:919-23.
  13. Song W, Wang J, Han Z, Zhang Y, Zhang H, Wang W, Chang J, Xia B, Fan S, Zhang D, Wang J*, Wang HW*, Chai J*. Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13. Nature structural & molecular biology. 2015;22:782-7.
  14. Luo P, Yu X, Wang W, Fan S, Li X*, Wang J*. Crystal structure of a phosphorylation-coupled vitamin C transporter. Nature structural & molecular biology. 2015;22:238-41 (Cover).
 
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