教职员工
兼职教授
讲席教授
杰出人才
其他获奖
邓海腾

邓海腾,教授

 

学位

1985 武汉大学·学士     

1988 武汉大学·硕士     

1996 Pennsylvania State University      博士

University of Alberta 博士后

Oak Ridge National Laboratory      博士后

 

工作经历

1/2000-12/2001 讲师, 发育生物学系, 爱因斯坦医学院

12/2001-7/2003 助理教授, 医学系, 爱因斯坦医学院

8/2003-12/2003 助理教授, 内布拉斯加大学

1/2004-7/2009   研究助理教授, 洛克菲勒大学

9/2009-2/2011   研究副教授和蛋白质组中心主任,洛克菲勒大学

9/2008-Present  客座研究员, 纽约大学

3/2011-Present  客座教授, 洛克菲勒大学

3/2011-Present  教授 清华大学

 

会员

The New York Academy of Science; The American Chemical Society; The American Society for Mass Spectrometry

 

主要研究领域与方向

发展和应用蛋白质组学,代谢组学,和化学生物学的技术和方法。研究病原微生物-宿主细胞的相互作用。以细胞和小鼠为主要研究对象研究免疫细胞的抗原递呈机制并发现可能的肿瘤疫苗。 发现和鉴别癌症早期诊断的标记物并研究化疗药物的毒理和作用机制。研究氧化还原生物学在衰老和疾病中的功能和作用机制。 

 

代表性论文

1. Dun Hong, Hai-Qiang Yu, Haiteng Deng*, and Renshan Ge*Quantitative proteomic analysis of dexamethasone-induced effects on osteoblast differentiation, proliferation,and apoptosis in MC3T3-E1 cells using SILAC, Osteoporosis International 2011;22:2175-86.

 

2. Qingli Shi, Hui Xu, Haiqiang Yu, Yaozu Ye, Alvaro G. Estevez, Haiteng Deng and Gary E. Gibson, Inactivation and reactivation of the mitochondrial α-ketoglutarate dehydrogenase complex, Journal of the Biological Chemistry, 2011;286:17640-8. 

3. Kabirul Islam, Weihong Zheng, Haiqiang Yu, Caitlin Sengelaub, Haiteng Deng and Minkui Luo, Expanding Cofactor Repertoire of Protein Lysine Methyltransferase for Substrate Labeling, ACS Chem. Biol. 2011;6:679-84.

4. Chongdong Liu, Nawei Zhang, Haiqiang Yu, Zhenyu Zhang*, and Haiteng Deng*, Comprehensive Serum Analysis for Finding Pathogenic Factors in Preeclampsia, Placenta 32 (2011) 168-174.

5. Uttiya Basu, Fei-Long Meng, Celia Keim, Veronika Grinstein, Evangelos Pefanis, Jennifer Eccleston, Tingting Zhang, Darienne Myers, Duane R. Wesemann, Kurt Januszyk, Richard I. Gregory, Haiteng Deng, Christopher D. Lima and Frederick W. Alt, The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates, Cell 2011, 144, 353–363.

6.  Lina Cheng, Jiayin Zhang, Sana Ahmad, Lorene Rozier, Haiqian Yu, Haiteng Deng, and Yinghui Mao, Aurora B Regulates Formin mDia3 in Achieving Metaphase Chromosome Alignment, Developmental Cell 2011, 20, 342–352.

7. Doina M. Mihaia, Haiteng Deng, and Akira Kawamura, Reproducible enrichment of extracellular heat shock proteins from blood serum using monomeric avidin, Bioorganic & Medicinal Chemistry Letters 2011;21:4134-7.

8. Rui Wang, Weihong Zheng, Haiqiang Yu, Haiteng Deng, and Minkui Luo, Labeling Substrates of Protein Arginine Methyltransferase with Engineered Enzymes and Matched S-Adenosyl-l-methionine Analogues, Journal of the American Chemical Society 2011, 133, 7648–7651.

9. Bozzacco L, Yu H, A Zebroski H, Dengjel J, Deng H, Mojsov S, Steinman RM. Mass spectrometry analysis and quantitation of peptides presented on the MHC II molecules of mouse spleen dendritic cells. J Proteome Res. 2011;10:5016-30.

10. Xie T, Ren R, Zhang YY, Pang Y, Yan C, Gong X, He Y, Li W, Miao D, Hao Q, Deng H, Wang Z, Wu JW, Yan N. Molecular mechanism for the inhibition of a critical component in the Arabidopsis thaliana abscisic acid signal transduction pathways, SnRK2.6, by the protein phosphatase ABI1. J Biol Chem. 2012;287:794-802.

11.Weijiao Huang, Wooyoung Choi, Wanqiu Hu, Na Mi, Qiang Guo, Meisheng Ma, Mei Liu, Yuan Tian, Peilong Lu, Feng-Liang Wang, Haiteng Deng, Lei Liu, Ning Gao, Li Yu and Yigong Shi, Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein,Cell Research  22 (2012)473-489.

12.Kabirul Islam, Ian Bothwell, Yuling Chen, Caitlin Sengelaub, Rui Wang, Haiteng Deng, and Minkui Luo, Bioorthogonal Profiling of Protein Methylation Using Azido Derivative of S-Adenosyl-l-methionine, Journal of the American Chemical Society 134 (2012) 5909.    

13. Cong Yi,Wenzhi Feng,Xingqi Gong,Bing Hong,Fen-Jun Jiang, Yan Le, Meisheng Ma,Chengying Ma,Di Miao, Leili Ran,Yufen Sun,Jingjing Tong,Zhiping Xie,Xianghua Yan,Shaojin Zhang,Jingxiang Zheng,Jing Zhu,Haiteng Deng, Liyuan Zhu,Li Yu, Function and molecular mechanism of acetylation in autophagy regulation, Science 2012;336:474-7.

14. Di Wu, Qi Hu, Zhen Yan, Wen Chen, Chuangye Yan, Xi Huang, Jing Zhang, Panyu Yang, Haiteng Deng, Jiawei Wang, XingWang Deng & Yigong Shi,Structural basis of ultraviolet-B perception by UVR8, Nature 2012;484: 214–219.

15.Shan Feng, Enbin Tian, Lei Zhang, Qingtao Wang, and Haiteng Deng*, Development of the Fc-III Tagged Protein Expression System for Protein Purification and Detection, PLoS ONE 2012;7(8):e44208.

16. Leonia Bozzacco, Haiqiang Yu, Jörn Dengjel, Christine Trumpfheller, Henry A. Zebroski, Nawei Zhang, Victoria Küttner, Beatrix M. Ueberheide, Haiteng Deng, Brian T. Chait, Ralph M. Steinman, Svetlana Mojsov, David Fenyö, Strategy for Identifying Dendritic Cell-Processed CD4+ T Cell Epitopes from the HIV Gag p24 Protein, PLoS ONE 2012;7(7):e41897.

17. Ian R. Bothwell, Kabirul Islam, Yuling Chen, Weihong Zheng, Gil Blum, Haiteng Deng, and Minkui Luo, Se-Adenosyl-L-selenomethionine Cofactor Analogue as a Reporter of Protein Methylation, Journal of the American Chemical Society 2012 ;134:14905-12.

18. Ben Gold, Maneesh Pingle, Steven J. Brickner, Nilesh Shah, Julia Roberts, Mark Rundell, W. Clay Bracken, Thulasi Warrier, Selin Somersan, Aditya Venugopal, Crystal Darby, J. David Warren, Joseph Fernandez, Haiteng Deng, Ronald Realubit, Nathan Brot, Fraser Glickman, Ouathek Ouerfelli and Carl Nathan, A non-steroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials, Proceedings of the National Academy of Sciences 2012;109:16004-11.

19. Kabirul Islam, Yuling Chen, Hong Wu, Ian Bothwell, Gill Blum, Weihong Zheng, Jinrong Min, Haiteng Deng, Minkui Luo, Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation., Proceedings of the National Academy of Sciences 2013;110:16778-83.

20. Xi Liu, Shi-an Liu, Yingang Feng, Jian-Zhong Liu, Cheryl Avery, Hai-teng Deng, Kendal D. Hirschi, Xin-quan, Wang, and Ning-Hui Cheng, Structural insights into the N-terminal GIY-YIG endonuclease activity of Arabidopsis glutaredoxin AtGRXS16 in chloroplasts, Proceedings of the National Academy of Sciences 2013;110:9565-70.

21. Qiang Guo, Yuling Chen, Simon Goto, Hyouta Himeno, Haiteng Deng, Jianlin Lei, Ning Gao, Molecular function of RimM on the in vivo30S ribosomal subunit assembly revealed by cryo-electron microscopy and quantitative mass-spectrometry,  Nucleic Acids Research 2013;41:2609-20.

22. Shan Feng, Yiyi Gong, Guolishana Adelijiang, Haiteng Deng, Effects of Fc-IIItag on the activity and stability of target proteins, Protein Science 2013;22:1008-15.

23. Jia Wang, Xiaoyu Li, Lixu Jin, Haiyun Deng, Yuling Chen, Qingquan Lian, Renshan Ge Haiteng Deng, Gossypol Induces Apoptosis in Ovarian Cancer Cells through Oxidative Stress, Molecular BioSystems 2013;9:1489-97.

24. Haiping Tang, Enbing Tian, Chongdong Liu, Qingtao Wang, Haiteng Deng, Oxidative Stress Induces Monocyte Necrosis with Enrichment of the Cell-bound Albumin and Overexpression of Endoplasmic Reticulum and Mitochondrial Chaperones, PLoS ONE 2013;8(3):e59610.

25. Zuo W, Huang F, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng XH, Luo S, Gao C, Chen YG. c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor., Molecular Cell 2013;49:499-510.

26. Wang, Rui; Islam, Kabirul; Liu, Ying; Zheng, Weihong; Tang, Haiping; Lailler, Nathalie; Blum, Gil; Deng, Haiteng; Luo, Minkui, Profiling Genome-wide Chromatin Methylation with Engi-neered Posttranslation Apparatus within Living Cells, Journal of the American Chemical Society 2013 Jan 23;135(3):1048-56.

27. Liang Wang, Tian Piao, Muqing Cao, Tao Qin, Lei Huang, Haiteng Deng, Tonglin Mao, and Junmin Pan, Flagellar regeneration requires cytoplasmic microtubule depolymerization and kinesin-13, Journal of Cell Science 2013;126:1531-40.

28. Yan J, Li H, Li S, Yao R, Deng H, Xie Q, Xie D.,The Arabidopsis F-Box Protein CORONATINE INSENSITIVE1 Is Stabilized by SCFCOI1 and Degraded via the 26S Proteasome Pathway. Plant Cell 2013;25:486-98.

29.  Huang W, Choi W, Chen Y, Zhang Q, Deng H, He W, Shi Y., A proposed role for glutamine in cancer cell growth through acid resistance. Cell Research 2013;23:724-7.

30. Nawei Zhang, Danile Malamad, and Haiteng Deng*, Quantitative Analysis of Differentially Expressed Salivary Proteins in HIV-1 Seropositive Individuals, Analytica Chimica Acta 2013;774:61-6. 

31. Enbing Tian, Haiping Tang, Chongdong Liu, Qingtao Wang, Haiteng Deng, Oxidative Stress Induces Monocyte Necrosis with Enrichment of the Cell-bound Albumin and Overexpression of Endoplasmic Reticulum and Mitochondrial Chaperones, Proteome Science 2013;11:24.

32. Lu P, Ma D, Chen Y, Guo Y, Chen GQ, Deng H, Shi Y., L-glutamine provides acid resistance for Escherichia coli through enzymatic release of ammonia. Cell Research 2013;23:635-44.

33. Ningning Li, Yuling Chen, Qiang Guo, Yixiao Zhang, Yi Yuan, Haiteng Deng, Jianlin Lei, Ning Gao, Cryo-EM structures of the late-stage assembly intermediates of the bacterial 50S ribosomal subunit. Nucleic Acids Res. 2013;41:7073-83.

34. Zehan Hu, Di Miao, Haiteng Deng, Jijie Chai, Crystal structure of NLRC4 reveals its autoinhibition mechanism, Science 2013;341:172-5.

35. Heyi Yang, Bo Zhou, Haiteng Deng, Mechthild Prinz, Donald Siegel, Body Fluid Identification by Mass Spectrometry. International Journal of Legal Medicine 2013;127:1065-77.

36. Ke Chen, Kongming Wu, Michael Gormley, Adam Ertel, Wei Zhang, Jie Zhou, Zhiping Li, Hallgeir Rui, Andrew A. Quong, Steven McMahon, Haiteng Deng, Michael P. Lisanti, Chenguang Wang, Richard G. Pestell, Acetylation Of The Cell-fate Factor Dachshund Determines P53 Binding And Signaling Module In Breast Cancer. Oncotarget 2013;4:923-35..

37. Cao L-S, Wang J, Chen Y, Deng H, Wang Z-X, Wu J-W, Structural Basis for the Regulation of Maternal Embryonic Leucine Zipper Kinase. PLoS ONE (2013) 8(7): e70031.

38. Ran Tao, Hua Xue, Jianping Zhang, Jieyuan Liu, Haiteng Deng, Ye-Guang Chen, The deacetylase Rpd3 facilitates checkpoint adaptation by preventing 2 Rad53 over-activation, Molecular and Cellular Biology 2013;33:4212-24.

39. Guo, Han; Wang, Rui; Zheng, Weihong; Chen, Yuling; Blum, Gil; Deng, Haiteng; Luo, Minkui, Profiling Substrates of Protein Arginine N-Methyltransferase 3 with S-Adenosyl-L-methionine Analogues, ACS Chemical Biology 2014;9(2):476-84.

40. Shan Feng, Xiaoyan Zheng, Dong Wang, Yiyi Gong, Qingtao Wang, Haiteng Deng, Systematic Analysis of Reactivities and Fragmentation of Glutathione and Its Isomer GluCysGly, Journal Physical Chemistry in press.

41. Yongjing Cheng, Yuling Chen, Xiaolin Sun, Yuhui Li, Cibo Huang, Haiteng Deng*, and Zhanguo Li*, Identification of Potential Serum Biomarkers for Rheumatoid Arthritis by High-Resolution Quantitative Proteomic Analysis, Inflammation 2014 Mar 30. PMID:24682873.

42. Zhang J, Zhou S, Zhang Q, Feng S, Chen Y, Zheng H, Wang X, Zhao W, Zhang T, Zhou Y, Deng H, Lin J, Chen F., Proteomic Analysis of RBP4/Vitamin A in Children with Cleft Lip and/or Palate, J Dent Res. 2014 Apr 2. doi: 10.1177/0022034514530397.

43. Yang Z, Guo Q, Goto S, Chen Y, Li N, Yan K, Zhang Y, Muto A, Deng H, Himeno H, Lei J, Gao N., Structural insights into the assembly of the 30S ribosomal subunit in vivo: functional role of S5 and location of the 17S rRNA precursor sequence, Protein Cell 2014 Mar 28. PMID:24671761.

44. Dong CM, Wang XL, Wang GM, Zhang WJ, Zhu L, Gao S, Yang DJ, Qin Y, Liang QJ, Chen YL, Deng HT, Ning K, Liang AB, Gao ZL, Xu J., A stress-induced cellular aging model with postnatal neural stem cells. Cell Death Dis. 2014 Mar 13;5:e1116. doi: 10.1038/cddis.2014.82. PMID:24625975

45. Yadong Hu, Helin Wang, Renhua Xu, Qingtao Wang, Haiteng Deng, NAD-Mediated Protein Expression, Cell Proliferation, and Responses to Oxidative Stress, Journal of Proteome Research 2014;13(2):786-95.

丛书章节

Amanda Chen, Haiqiang Yu, Haiteng Deng and W. Beau Mitchell, Mechanisms of αIIbβ3 Biogenesis in the Megakaryocyte: A Proteomics Approach in Hematology - Science and Practice, Edited by Charles H. Lawrie, ISBN 978-953-51-0174-1, Publisher: InTech, March 02, 2012 DOI: 10.5772/2259.

Haiteng Deng, Proteomics in Drug Discovery in Handbook of Drug Screening, R. Seethala, Eds, Informa Healthcare, May 2009.

Denis L. Rousseau, David Li, Eric Y. Hayden, Haiteng Deng and Syun-Ru Yeh, Protein-ligand interactions in mammalian nitric oxide synthase, in THE SMALLEST BIOMOLECULES: DIATOMICS AND THEIR INTERACTIONS WITH HEME PROTEINS, Abhik Ghosh, Eds, Elsevier, Dec 2007.

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