Full time faculty

Adjunct professor

Chair professor

Administration

Qin SHEN

Qin Shen, Professor

EDUCATION

2001        PhD,    Albany Medical College, Center for Neuropharmacology and Neuroscience

1999        MS,      Albany Medical College, Center for Neuropharmacology and Neuroscience

1991        BS,      Shanghai Medical University (now Fudan University Shanghai Medical College), Pharmacology

PROFESSIONAL EXPERIENCE

2010-          Professor, Tsinghua University

2007-2010       Assistant Professor, New York Neural Stem Cell Institute, New York, USA   

2006-2010        Assistant Professor,  Albany Medical Center, Center for Neuropharmacology and Neuroscience, New York£¬ USA        

2001-2006        Postdoc Fellow, Albany Medical College, Center for Neuropharmacology and Neuroscience

1991-1996        Research and Teaching Assistant, Department of Neurobiology, State Key Laboratory of Medical Neurobiology

Research interests:

Molecular mechanism regulating neural stem cell self-renewal and fate choices

Interaction between neural stem cells and microenvironment (stem cell niche) which is critical for stem cell therapy.

Stem cell function in neurological diseases.

Human ES and iPS-derived neural stem cells for modeling developmental brain disorders.

Selected Publication (*corresponding author)

  1. Chuang, S.M., Wang, Y., Wang, Q., Liu, K.M., Shen Q*. (2011) Ebf2 Marks Early Cortical Neurogenesis and Regulates the Generation of Cajal-Retzius Neurons in the Developing Cerebral Cortex. Dev Neurosci. 33(6):479-93
  2. Erzsebet, K., Goderie, S., Wang, Y., Lin, G., Roysam, B., Shen, Q., Temple, S. (2010) Adult SVZ lineage cells home to and leave the niche via differential responses to SDF1/CXCR4 signaling.  Cell Stem Cell 7(2):163-173
  3. Shen, Q.* and Temple, S. (2009) Fine control: microRNA regulates adult neurogenesis. Nature Neurosci. 12 (4): 369-370
  4. Slater, J.L., Landman, K.A., Hughes, B.D., Shen, Q., Temple, S. (2009) Cell lineage tree models of neurogenesis. J Theor Biol. 256(2):164-79. Epub 2008 Oct 15.
  5. Kokovay, E., Shen, Q., Temple, S. (2008) The incredible elastic brain: how neural stem cells expand our minds. Neuron 60(3):420-9.
  6. Shen, Q., Wang, Y., Kokovay, E., Lin, G., Chuang, S.M., Goderie, S.K., Roysam, B., Temple, S. (2008) Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions. Cell Stem Cell 3(3):289-300.
  7. Shen, Q.*, Wang, Y., Dimos, J.T., Fasano, C.A., Phoenix, T.N., Lemischka, I.R., Ivanova, N.B., Stifani, S., Morrisey, E.E., Temple, S. (2006) The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. Nature Neurosci. 9(6):743-51
  8. Al-Kofahi, O., Radke, R.J., Goderie, S.K., Shen, Q., Temple, S., Roysam, B. (2006) Automated cell lineage construction: a rapid method to analyze clonal development established with murine neural progenitor cells. Cell Cycle 5(3):327-35.
  9. Shen, Q., Goderie, S., Jin, L., Karanth, N., Sun, Y., Abramova, N., Vincent, P., Pumiglia, K., Temple, S. (2004) Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science 304:1338-1340
  10. Li, H.S., Wang, D., Shen, Q., Schonemann, M.D., Gorski, J.A., Jones, K.R., Temple, S., Jan, L.Y., Jan, Y.N. (2003) Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron 40(6):1105-18.
  11. Shen, Q. and Temple, S. (2002) Creating asymmetric cell divisions by skewing endocytosis.  Science STKE. (162):PE52.
  12. Shen, Q., Zhong, W., Jan, Y.N., and Temple, S. (2002) Asymmetric m-Numb distribution is critical for asymmetric cell division of mouse cerebral cortical progenitor cells.  Development 129:4843-4853.
  13. Atluri, P., Fleck, M.W., Shen, Q., Mah, S.J., Stadfelt, D., Barnes, W., Goderie, S.K., Temple, S., Schneider, A.S. (2001) Functional Nicotinic acetylcholine receptor expression in stem and progenitor cells of early embryonic mouse cerebral cortex.  Dev. Biol. 240(1):143-56.
  14. Qian, X., Shen, Q., Goderie, S., He, W., Capela, A.M., and Temple, S. (2000) Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical cells. Neuron 28:69-80. co-first author
  15. Qian, X., Goderie, S., Shen, Q., Stern, J. H. and Temple, S. (1998) Intrinsic programs of patterned cell lineages in isolated vertebrate CNS ventricular zone cells.  Development 125:3143-3152
  16. Shen, Q., Qian, X., Capela, A. and Temple, S. (1998) Stem cells in the embryonic cerebral cortex: Their role in histogenesis and patterning.  J. of Neurobio. 36:162-174


Tsinghua University,Beijing,China,100084
Tel:+86-10-62772269  Fax:+86-10-62788604  Email:swxrs@tsinghua.edu.cn