Full time faculty

Adjunct professor

Chair professor

Administration

Yeguang Chen

 

Ye-Guang Chen, Ph.D.

Professor; Cheung Kong Scholar; Recipient of the National Science Foundation for Outstanding Young Scientists of China

1983, BS, Jiangxi University

1986, MS, Jiangxi University

1990, MS, Fordham University, New York

1996, Ph.D., Albert Einstein College of Medicine, New York

1996-2000, Post-doctoral Research Associate, Memorial Sloan-Kettering Cancer Center/Howard Hughes Medical Institute
2000-2002, Assistant Professor, University of California, Riverside
2002-present, Professor, Tsinghua University

Research Interests:

The molecular mechanism of cell signaling. His research interests concern how TGF-beta and Wnt signaling are regulated and aims to understand their roles in embryogenesis, stem cell self-renewal and differentiation, tissue fibrosis and tumorigenesis.

Selected Publications:

1.      Zuo W, Huang F, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng XH, Luo S, Gao C, Chen YG#  2013  c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor.  Molecular Cell, 49(3):499-510.

2.      Li Z, Fei1 T, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG#  2012  BMP4 signaling acts via Dual Specificity Phosphatase 9 to control ERK activity in mouse embryonic stem cells. Cell Stem Cell, 10:171-182.

3.      Zhao B, Wang Q, Du J, Luo S, Xia J, Chen YG#  2012  PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor, Cell Research, 22:1467-1478.

4.      Gao C, Cao W, Bao W, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG#  2010  Autophagy negatively regulates Wnt signaling by promoting Dishevelled degradation. Nature Cell Biology, 12:781-790.

5.      Fei T, Xia K, Li Z, Zhou B, Zhu S, Chen H, Zhang J, Chen Z, Xiao H, Han JD#, Chen YG#  2010  Genome-wide Mapping of Smad Target Genes Reveals the Role of BMP Signaling in Embryonic Stem Cell Fate Determination. Genome Research, 20:36-44.

6.      Zhang W, Jiang Y, Wang Q, Ma X, Xiao Z, Zuo W, Fang X#, Chen YG#  2009  Single molecule imaging reveals transforming growth factor-β-induced type II receptor dimerization. Proc Natl Acad Sci. USA, 106:15679-15683.

7.      Wang Q, Huang Z, Xue H, Jin C, Ju XL, Han JD, Chen YG#  2008  MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood, 111:588-595.

8.      Ma J, Wang Q, Fei T, Han JD, Chen YG# 2007 MCP-1 mediates TGF-β-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood, 109:987-994.

9.      Zhang S, Fei T, Zhang L, Zhang R, Chen F, Ning Y, Han Y, Feng XH, Meng A, Chen YG#  2007  Smad7 antagonizes TGF-β signaling in the nucleus by interfering with functional Smad-DNA complex formation.  Molecular and Cellular Biology, 27:4488-4499.

10.  Zhang, L., Zhou, H., Su, Y., Sun, S., Zhang, H., Zhang, L., Zhang, Y., Ning, Y., Chen, YG# and Meng, A# 2004 Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science, 306:114-117 

Contact:

Tel: 86-10-62784794; Fax: 86-10-62794376

E-mail: ygchen@mail.tsinghua.edu.cn

 



Tsinghua University,Beijing,China,100084
Tel:+86-10-62772269  Fax:+86-10-62788604  Email:swxrs@tsinghua.edu.cn