Full time faculty

Adjunct professor

Chair professor

Administration

Yinghua CHEN

Yinghua Chen Ph.D.

Professor, Cheung Kong Scholar, Winner of the National Science Foundation for Outstanding Young Scientists of China
BS, Wuhan University.
Ph.D., University Munich.
Dr.Chen holds professor (2002- ) of the School of Life Sciences,Tsinghua University.

Main Research Fields:
·Mechanism of HIV infection.
·Virus mutation and anti-mutation strategy.
·Recombinant epitope-vaccine.

Selected Publications

  1. Chang Zhou, Lu Lu, Suiyi Tan, Shibo Jiang*, Ying-Hua Chen*. HIV-1 gp41 ectodomain induces activation of the CD74-mediated ERK/MAPK pathway to enhance viral infection. Journal of Biological Chemistry 2011.286: 44869-77.
  2. Xiaowen Yu, Lu Lu, Lifeng Cai, Pei Tong, Suiyi Tan, Peng Zou, Fanxia Meng, Ying-hua Chen*, and Shibo Jiang*. Mutations of Gln64 in the HIV-1 gp41 N-terminal heptad repeat render viruses resistant to peptide HIV fusion inhibitors targeting gp41 pocket. Journal of Virology. 2012, 86: 589-593.
  3. Zhu Y, Lu L, Xu LL, Yang HW, Jiang Shibo*, Chen YH*. Identification of a gp41 Core-binding Molecule with Homologous Sequence of Human TNNI3K Like Protein as a Novel Human Immunodeficiency Viruses Type 1 Entry Inhibitor. Journal of Virology. 2010;84(18):9359-68.
  4. Chen X, Lu L, Qi Z, Lu H, Wang J, Yu X, Chen YH*, Shibo Jiang*. Novel recombinant engineered gp41 N-terminal heptad-repeat trimers: potential as anti-HIV-1 therapeutics or microbicides. Journal of Biological Chemstry. 2010;285(33):25506-15.
  5. Huang JH, Qi Z, Wu F, Kotula L, Jiang SB*, Chen YH*. Interaction of HIV-1 gp41 core with NPF motif in Epsin - Implication in endocytosis of HIV. Journal of Biological Chemstry 2008;283(22):14994-15002.
  6. Lu L, Zhu Y, Huang JH, Chen X, Yang HW, Jiang SB*, Chen YH*. Surface exposure of the HIV-1 Env cytoplasmic tail LLP2 domain during the membrane fusion process - Interaction with gp41 fusion core. Journal of Biological Chemstry.2008;283(24):16723-16731.
  7. Huang JH, Lu L, Lu H, Chen X, Jiang S, Chen YH. Identification of the HIV-1 gp41 core-binding motif in the scaffolding domain of caveolin-1. Journal of Biological Chemistry. 2007, 282: 6143–6152.
  8. Huang JH, Yang HW, Liu S, Jiang S, Chen YH. The mechanism by which molecules containing the HIV-1 gp41 core-binding motif HXXNPF inhibit HIV-1 envelope glycoprotein-mediated syncytium-formation. Biochemical Journal.2007, 403: 565-571.

Contact:

Tel£º+86-10-62789385
Fax£º+86-10-62771613
E-mail:chenyh@tsinghua.edu.cn



Tsinghua University,Beijing,China,100084
Tel:+86-10-62772269  Fax:+86-10-62788604  Email:swxrs@tsinghua.edu.cn