Junmin Pan, Ph.D.
Professor in Cell Biology
School of Life Sciences
Haidian district, Beijing 100084
P. R. China
HeBei Normal University, B.A., 1986
Institute of Hydrobiology, Chinese Academy of Sciences,M.S., 1989
University of Freiburg, Germany, Ph.D., 1996
UT Southwestern Medical Center, Postdoctora, 1997-1999
UT Southwestern Medical Center, Instructor, 1999-2001
UT Southwestern Medical Center, Research Assistant Prof., 2001-2006
Tsinghua University, Professor, 2006 - present
Cilia and eukaryotic flagella (interchangeable terms) are microtubule-based cellular surface protrusions. They play essential roles in cell motility, signaling to regulate various biological processes including sensory transduction, development, tissues and organ homeostasis. Thus, defects in the structure and/or function of cilia/flagella have been implicated in various human disorders including renal diseases, respiratory disorders, developmental abnormality and even diabetes. The structural integrity and proper function of cilia/flagella requires coordinated regulation of the assembly and disassembly of cilia.
We are using Chlamydomonas, a uni-cellular green alga, as a model organism to study the mechanisms underlying the assembly and disassembly of cilia. Previously we have identified an aurora-like protein kinase - CALK, which is required for flagellar disassembly. Recently, we discovered that microtubule depolymerizing kinesin-CrKinesin13 is phosphorylated and is involved in flagellar assembly and disassembly. Currently we focus on the regulation control of CALK and CrKinesin13. Since cilia disassembly occurs prior to cell division, we also aim to understand how cilia disassembly regulates the cell cycle progression. In addition, we are characterizing several mutants defective in the assembly and disassembly of flagella. These defective genes may be involved in the regulation of Intraflagellar transport, a bidirectional transport process between the flagellar tip and the cell body, which is required for flagellar assembly and disassembly. Since cilia and eukaryotic flagella are conserved cellular organelles, our research findings will have great impact on understanding cilia-related human disorders and may provide guidance on possible diagnostics and treatment for these diseases.
- Luo M, M Cao, Y Kan, G Li, W Snell and Junmin Pan*. 2011. Protein phosphosphorylation states of an auroa-like kinase marks the length of growing flagella. Current Biology. (accepted).
- Yinan Kan, Junmin Pan*. 2010. a one-shot solution to bacterial and fungal contamination in the green alga Chlamydomonas reinhardtii culture by using an antibiotic cocktail. Journal of Phycology, 46, 1356-1358.
- Piao tian, Minna Luo,Liang Wang,Yan Guo,De Li, Peng Li, William J. Snell, Junmin Pan*. 2009. A microtubule depolymerizing kinesin functions during both flagellar disassembly and flagellar assembly in Chlamydomonas. PNAS, 106, 4713-4718(direct submission).
- Cao Muqing, Yu Fu, Yan Guo and Junmin Pan*. 2009. Chlamydomonas (Chlorophyceae) colony PCR. Protoplasma, 235, 107.
- Cao Muqing, Guihua, Li, and Junmin Pan*. 2009. Regulation of cilia assembly, disassembly, and length by protein phosphorylation. Methods in Cell Biology, 94, 333-346.
- Junmin Pan*. 2008. Cilia and ciliopathies: From Chlamydomonas and beyond. Sci China Ser C-Life Sci, 51, 479-486.
- Junmin Pan and William Snell. 2007. The primary cilum: Keeper of the key to cell division. Cell, 129, 1255-1257.
- Merchant S., …, Junmin Pan, et al., 2007. The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions. Science, 318, 245-250.（作者较多，本人仅为中间作者）
- Wang Q. Junmin Pan, and William Snell. 2006. A new role for intraflagellar transport: Intraflagellar transport particles participate directly in signal transduction during cilium-generated signaling in Chlamydomonas. Cell, 125, 549-562
- Junmin Pan and William Snell. 2005. Chlamydomonas shortens its flagella by activating disassembly, stimulating IFT particles and blocking anterograde cargo loading. Developmental Cell, 9, 431-438.