Full time faculty

Adjunct professor

Chair professor

Administration

Senfang Sui

Sen-Fang Sui, Ph.D.

Professor, Member of Chinese Academy of Sciences

 

1964-1970

B. S., Department of Precision Instrument, Tsinghua University.

1978-1981

M.S., Department of Engineering Physics, Tsinghua University.

1985-1988

Ph.D., Biophysics Institute, Technical University Munich.

1989-1991

Associate Professor, Department of Biological Sciences and Biotechnology, Tsinghua University.

1991.01-present

Professor, School of Life Sciences (replacing the Department of Biological Sciences and Biotechnology in September of 2009), Tsinghua University.

 

 

 

Research Interest

Using cryo-electron microscopy in combination with biochemical, biophysical and cellular methods, our lab currently focuses on: 1) structures, functions and mechanisms of large protein complexes and macromolecular machines; 2) structures, functions and mechanisms of membrane proteins; 3) molecular mechanisms of membrane trafficking, lipid-protein interactions, membrane-related human diseases.

Representative Publications

  1. Zhang, L., Wang, X., Fan, F., Wang, H.W., Wang, J.*, Li, X.*, Sui, S.F.* (2017) Cryo-EM structure of Nma111p, a unique HtrA protease composed of two protease domains and four PDZ domains. Cell Resarch, doi: 10.1038/cr.2017.5. [Epub ahead of print]
  2. Wang, X., Li, B., Guo, Y., Shen, S., Zhao, L., Zhang, P., Sun, Y., Sui, S.F.*, Deng, F.*, Lou, Z.* (2016) Molecular basis for the formation of ribonucleoprotein complex of Crimean-Congo hemorrhagic fever virus. J. Struct. Biol. 196, 455-465.
  3. Zhang, J., Pan, X., Yan, K., Sun, S., Gao, N.*, Sui, S.F.* (2015) Mechanisms of ribosome stalling by SecM at multiple elongation steps. Elife 4, pii: e09684.
  4. Hu, Z., Zhou, Q., Zhang, C., Fan, S., Cheng, W., Zhao, Y., Shao, F., Wang, H.W., Sui, S.F.*, Chai, J.* (2015). Structural and biochemical basis for induced self-propagation of NLRC4. Science 350, 399-404.
  5. Chang, L., Liu, X., Li, Y., Liu, C.C., Yang, F., Zhao, J.*, Sui, S.F.* (2015) Structural organization of an intact phycobilisome and its association with photosystem II. Cell Research 25, 726-737.
  6. Zhou, Q., Huang, X., Sun, S., Li, X., Wang, H.W.*, Sui, S.F.* (2015). Cryo-EM structure of SNAP-SNARE assembly in 20S particle. Cell Research 25, 551-560.
  7. Li, B., Wang, Q., Pan, X., Fernández de Castro I., Sun, Y., Guo, Y., Tao, X., Risco, C., Sui, S.F., Lou, Z.* (2013) Bunyamwera virus possesses a distinct nucleocapsid protein to facilitate genome encapsidation. Proc. Natl. Acad. Sci. U. S. A. 110, 9048-9053.
  8. Chang, L.F., Chen, S., Liu, C.C., Pan, X., Jiang, J., Bai, X.C., Xie, X., Wang, H.W., Sui, S.F.* (2012) Structural characterization of full-length NSF and 20S particles. Nat. Struct. Mol. Biol. 19, 268-275.
  9. Liu, L., Feng, D., Chen, G., Chen, M., Zheng, Q., Song, P., Ma, Q., Zhu, C., Wang, R., Qi, W., Huang, L., Xue, P., Li, B., Wang, X., Jin, H., Wang, J., Yang, F., Liu, P., Zhu, Y., Sui, S.F., Chen Q.* (2012) Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat. Cell Biol. 14, 177-185.

Contact

Tel:+86-10-62792083/62784768

E-mail: suisf@mail.tsinghua.edu.cn

Lab website: http://suilab.life.tsinghua.edu.cn/

 

 



Tsinghua University,Beijing,China,100084
Tel:+86-10-62788604  Fax:+86-10-62788604  Email:admin-life@biomed.tsinghua.edu.cn