Full time faculty

Adjunct professor

Chair professor


Senfang Sui

Sen-Fang Sui, Ph.D.

Professor, Member of Chinese Academy of Sciences



B. S., Department of Precision Instrument, Tsinghua University.


M.S., Department of Engineering Physics, Tsinghua University.


Ph.D., Biophysics Institute, Technical University Munich.


Associate Professor, Department of Biological Sciences and Biotechnology, Tsinghua University.


Professor, School of Life Sciences (replacing the Department of Biological Sciences and Biotechnology in September of 2009), Tsinghua University.




Research Interest

Using cryo-electron microscopy in combination with biochemical, biophysical and cellular methods, our lab currently focuses on: 1) structures, functions and mechanisms of large protein complexes and macromolecular machines; 2) structures, functions and mechanisms of membrane proteins; 3) molecular mechanisms of membrane trafficking, lipid-protein interactions, membrane-related human diseases.

Representative Publications

  1. Zhang L, Wang X, Fan F, Wang HW, Wang J*, Li X*, Sui SF*. (2017) Cryo-EM structure of Nma111p, a unique HtrA protease composed of two protease domains and four PDZ domains. Cell Research, 27:582-585.
  2. Wang, X., Li, B., Guo, Y., Shen, S., Zhao, L., Zhang, P., Sun, Y., Sui, S.F.*, Deng, F.*, Lou, Z.* (2016) Molecular basis for the formation of ribonucleoprotein complex of Crimean-Congo hemorrhagic fever virus. J. Struct. Biol. 196, 455-465.
  3. Zhang, J., Pan, X., Yan, K., Sun, S., Gao, N.*, Sui, S.F.* (2015) Mechanisms of ribosome stalling by SecM at multiple elongation steps. Elife 4, pii: e09684.
  4. Hu, Z., Zhou, Q., Zhang, C., Fan, S., Cheng, W., Zhao, Y., Shao, F., Wang, H.W., Sui, S.F.*, Chai, J.* (2015). Structural and biochemical basis for induced self-propagation of NLRC4. Science 350, 399-404.
  5. Chang, L., Liu, X., Li, Y., Liu, C.C., Yang, F., Zhao, J.*, Sui, S.F.* (2015) Structural organization of an intact phycobilisome and its association with photosystem II. Cell Research 25726-737.
  6. Zhou, Q., Huang, X., Sun, S., Li, X., Wang, H.W.*, Sui, S.F.* (2015). Cryo-EM structure of SNAP-SNARE assembly in 20S particle. Cell Research 25, 551-560.
  7. Li, B., Wang, Q., Pan, X., Fernández de Castro I., Sun, Y., Guo, Y., Tao, X., Risco, C., Sui, S.F., Lou, Z.* (2013) Bunyamwera virus possesses a distinct nucleocapsid protein to facilitate genome encapsidation. Proc. Natl. Acad. Sci. U. S. A. 110, 9048-9053.
  8. Chang, L.F., Chen, S., Liu, C.C., Pan, X., Jiang, J., Bai, X.C., Xie, X., Wang, H.W., Sui, S.F.* (2012) Structural characterization of full-length NSF and 20S particles. Nat. Struct. Mol. Biol. 19, 268-275.
  9. Liu, L., Feng, D., Chen, G., Chen, M., Zheng, Q., Song, P., Ma, Q., Zhu, C., Wang, R., Qi, W., Huang, L., Xue, P., Li, B., Wang, X., Jin, H., Wang, J., Yang, F., Liu, P., Zhu, Y., Sui, S.F., Chen Q.* (2012) Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat. Cell Biol. 14, 177-185.
  10. Yang X, Yang F, Wang W, Lin G, Hu Z, Han Z, Qi Y, Zhang L, Wang J, Sui SF*, Chai J*. (2017) Structural basis for specific flagellin recognition by the NLR protein NAIP5. Cell Research, 28(1):35-47.
  11. Zhang J, Ma J, Liu D, Qin S, Sun S*, Zhao J, Sui SF*. (2017) Structure of phycobilisome from the red alga Griffithsia pacifica. Nature, 551:57-63.
  12. Sun S, Li L, Yang F, Wang X, Fan F, Yang M, Chen C, Li X, Wang HW, Sui SF*. (2017) Cryo-EM structures of the ATP-bound Vps4-E233Q hexamer and its complex with Vta1 at near-atomic resolution. Nat Commun., 8:16064.



E-mail: suisf@mail.tsinghua.edu.cn

Lab website: http://suilab.life.tsinghua.edu.cn/



Tsinghua University,Beijing,China,100084
Tel:+86-10-62788604  Fax:+86-10-62788604  Email:admin-life@biomed.tsinghua.edu.cn