Full time faculty

Adjunct professor

Chair professor


Zhixin Wang

Zhi-Xin Wang, Ph.D., Professor, Recipient of The National Science Fund for Distinguished Young Scholars

1977:   B.S. (Chemistry) University of Tsinghua, Beijing, China.
1988:   Ph.D. (Biochemistry) Institute of Biophysics, Academia Sinica, China.

Research Experience:
1977-1981:Teaching assistant, Department of Chemistry and Chemical Engineering, Tsinghua University, China
1988-1989:Associate professor, Institute of Biophysics, Academia Sinica, China
1989-1991:Postdoctoral associate, Department of Chemistry, Cornell University, USA
1991-1993:Research associate, Department of Biochemistry, North Dakota State University, USA
1993-2003:Professor, Institute of Biophysics, Academia Sinica, China
1997-2003:Director, National Laboratory of Biomacromolecules, China
1999-2003:Director, Institute of Biophysics, Academia Sinica, China
2003-¡¡Professor, School of Life Sciences, Tsinghua University, China

Research Interests:
Molecular enzymology

Introduction to protein science’ for undergraduates
Enzyme kinetics’ for graduates

Selected Publications: 

  • Wang J, Wu JW and Wang ZX*. (2011) Mechanistic studies of the autoactivation of PAK2: a two-step model of cis initiation followed by trans amplification. J Biol Chem, 286 (4): 2689-95.
  • Zhang YY, Mei ZQ, Wu JW*, Wang ZX*. (2008) Enzymatic activity and substrate specificity of mitogen-activated protein kinase p38alpha in different phosphorylation states. J Biol Chem. 283(39):26591-601.
  • Wang ZX*, Wu JW.* (2007) The complete pathway for ERK2-catalyzed reaction. Evidence for an iso random Bi-Bi mechanism. J Biol Chem. 282(38): 27678-84.
  • Liu JH and Wang ZX*. (2004) Kinetic analysis of ligand-induced autocatalytic reactions. Biochem. J.379(Pt 3), 697-702.
  • Wu H and Wang ZX*. (2003) The mechanism of p21-activated protein kinase 2 autoactivation. J. Biol. Chem. 278(43), 41768-78.
  • Li SJ, Wang J, Ma L, Lu C, Wang J, Wu JW*, Wang ZX*. (2016) Cooperative autoinhibition and multi-level activation mechanisms of calcineurin. Cell Res. 26, 336-49.
  • Liu X, Zhang CS, Lu C, Lin SC, Wu JW*, Wang ZX*. (2016) A conserved motif in JNK/p38-specific MAPK phosphatases as a determinant for JNK1 recognition and inactivation. Nat Commun. 7, 10879.
  • Wang J, Jiang J, Wang J, Chen L, Fan SL, Wu JW, Wang X, Wang ZX*. (2014) Structural insights into the negative regulation of BRI1 signaling by BRI1-interacting protein BKI1. Cell Res. 24, 1328-41.
  • Wang J, Wu JW, Wang ZX*. (2011) Structural Insights into the Autoactivation Mechanism of p21-Activated Protein Kinase. Structure. 19, 1752-61.
  • Zhang YY, Wu JW, Wang ZX*. (2011) A distinct interaction mode revealed by the crystal structure of the Kinase p38 with the MAPK binding domain of the Phosphatase MKP5. Sci Signal. 4, ra88.
  • Zhang YY, Wu JW, Wang ZX*. (2011) MAP kinase phosphatase 3-mediated crosstalk between MAP kinases ERK2 and p38α. J Biol Chem. 286, 16150-62.

1990, Natural Science Award of the Chinese Academy of Sciences, First Class
1993, National Natural Science Prize, Second Class
1993, Young Scientist Award of the Chinese Academy of Sciences, First Class
1994, Prize for Young Scientist of China
1997, Member,The Chinese Academy of Sciences
1999, Fellow, The Third Word Academy of Sciences

Chair, Chinese Society of Biochemistry and Molecular Biology
Member, Chinese Society of Biophysics
Member, American Society for Biochemistry and Molecular Biology

Mail: School of Life Sciences, Tsinghua University, Beijing 100084

Tsinghua University,Beijing,China,100084
Tel:+86-10-62788604  Fax:+86-10-62788604  Email:admin-life@biomed.tsinghua.edu.cn