Full time faculty

Adjunct professor

Chair professor

Administration

Jiawei Wu

Jia-Wei Wu, Ph.D., Professor

Education:
1990-1994, B.S., Biochemistry, Department for Intensive Instruction (Kuang Yaming Honors School), Nanjing University, Nanjing, Jiangsu Province, China
1994-1999, Ph.D., Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

Research Experience:
1999-2003, Post-doctoral Research Associate, Department of Molecular Biology, Princeton University, USA
2003-, Professor, School of Life Sciences, Tsinghua University, China

Research Interests:
Structural and biochemical studies of biomacromolecules:
Structure and function of key molecules involved in diabetes and obesity
Function of scaffold proteins and its partners in Wnt and JNK pathways
Molecular regulation of kinases and phosphatases in MAPK signaling
Degradation mechanism of Smad in TGF- signaling

Courses:
Introduction to protein science’ for undergraduates
Structure and function of Biomacromolecules’ for graduates

Selected Publications:

  • Wang L, Liu YT, Hao R, Chen L, Chang ZJ, Wang HR, Wang ZX, Wu JW*. (2011) Molecular mechanism of the negative regulation of Smad1/5 by CHIP. [Epub ahead of print]
  • Liu YT, Dan QJ, Wang J, Feng Y, Chen L, Liang J, Li Q, Lin SC, Wang ZX, Wu JW*. (2011) Molecular basis of Wnt activation via the DIX-domain protein Ccd1. J Biol Chem. 286(10):8597-608.
  • Gao X, Wang J, Yu DQ, Bian F, Xie BB, Chen XL, Zhou BC, Lai LH, Wang ZX, Wu JW*, Zhang YZ*. (2010) Structural basis for the autoprocessing of zinc metalloproteases in the thermolysin family. Proc Natl Acad Sci U S A. 107(41):17569-74.
  • Zhao PL, Wang L, Zhu XL, Huang X, Zhan CG*, Wu JW*, Yang GF*. (2010) Subnanomolar inhibitor of cytochrome bc(1) complex designed by optimizing interaction with conformationally flexible residues. J Am Chem Soc. 132(1):185-94
  • Chen L, Jiao ZH, Zheng LS, Zhang YY, Xie ST, Wang ZX, Wu JW*. (2009) Structural insight into the autoinhibition mechanism of AMP-activated protein kinase. Nature. 459(7250):1146-9.

Honors, Awards and Fellowships:
1997¡¡Presidential Excellent Award, Chinese Academy of Sciences
1998¡¡Di’ao Scholarship, Chinese Academy of Sciences
1999¡¡Presidential Outstanding Award, Chinese Academy of Sciences
2001¡¡Excellent Ph.D. Thesis, China

Society Memberships:
Chinese Society of Biochemistry and Molecular Biology, Member
Society for Enzymology, CSBMB, Councilor
Chinese Crystallographic Society, Member


Contact:
Tel£º010-62789387
Fax£º010-62792826
E-mail£ºjiaweiwu@mail.tsinghua.edu.cn
Mail: School of Life Sciences., Tsinghua University, Beijing 100084



Tsinghua University,Beijing,China,100084
Tel:+86-10-62772269  Fax:+86-10-62788604  Email:swxrs@tsinghua.edu.cn