Full time faculty

Adjunct professor

Chair professor


Jiawei Wu

Jia-Wei Wu, Ph.D., Professor

Chang Jiang Scholar

Recipient of The National Science Fund for Distinguished Young Scholars

1990-1994, B.S., Biochemistry, Department for Intensive Instruction (Kuang Yaming Honors School), Nanjing University, Nanjing, Jiangsu Province, China
1994-1999, Ph.D., Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

Research Experience:
1999-2003, Post-doctoral Research Associate, Department of Molecular Biology, Princeton University, USA
2003-, Professor, School of Life Sciences, Tsinghua University, China

Research Interests:
Structural and biochemical studies of biomacromolecules:
Structure and function of key molecules involved in diabetes and obesity
Function of scaffold proteins and its partners in Wnt and JNK pathways
Molecular regulation of kinases and phosphatases in MAPK signaling
Degradation mechanism of Smad in TGF- signaling

Introduction to protein science’ for undergraduates
Structure and function of Biomacromolecules’ for graduates

Selected Publications:

  • Wang L, Liu YT, Hao R, Chen L, Chang ZJ, Wang HR, Wang ZX, Wu JW*. (2011) Molecular mechanism of the negative regulation of Smad1/5 by CHIP. [Epub ahead of print]
  • Liu YT, Dan QJ, Wang J, Feng Y, Chen L, Liang J, Li Q, Lin SC, Wang ZX, Wu JW*. (2011) Molecular basis of Wnt activation via the DIX-domain protein Ccd1. J Biol Chem. 286(10):8597-608.
  • Gao X, Wang J, Yu DQ, Bian F, Xie BB, Chen XL, Zhou BC, Lai LH, Wang ZX, Wu JW*, Zhang YZ*. (2010) Structural basis for the autoprocessing of zinc metalloproteases in the thermolysin family. Proc Natl Acad Sci U S A. 107(41):17569-74.
  • Zhao PL, Wang L, Zhu XL, Huang X, Zhan CG*, Wu JW*, Yang GF*. (2010) Subnanomolar inhibitor of cytochrome bc(1) complex designed by optimizing interaction with conformationally flexible residues. J Am Chem Soc. 132(1):185-94
  • Chen L, Jiao ZH, Zheng LS, Zhang YY, Xie ST, Wang ZX, Wu JW*. (2009) Structural insight into the autoinhibition mechanism of AMP-activated protein kinase. Nature. 459(7250):1146-9.
  • Wu JX, Cheng YS, Wang J, Chen L, Ding M, Wu JW*. (2015) Structural insight into the mechanism of synergistic autoinhibition of SAD kinases. Nat Commun. 6:8953.
  • Chai N, Li WX, Wang J, Wang ZX, Yang SM*, Wu JW*. (2015) Structural basis for the Smad5 MH1 domain to recognize different DNA sequences. Nucleic Acids Res. 43(18):9051-64.
  • Xin FJ, Wang J, Zhao RQ, Wang ZX, Wu JW*. (2013) Coordinated regulation of AMPK activity by multiple elements in the α-subunit. Cell Res. 23(10):1237-1240.
  • Chen L, Xin FJ, Wang J, Hu J, Zhang YY, Wan S, Cao LS, Lu C, Li P, Yan SF, Neumann D, Schlattner U, Xia B, Wang ZX, Wu JW*. (2013) Conserved Regulatory Elements in AMPK. Nature. 498(7453):E8–E10.
  • Chen L, Wang J, Zhang YY, Yan SF, Neumann D, Schlattner U, Wang ZX, Wu JW*. (2012) AMPactivated protein kinase undergoes nucleotide-dependent conformational changes. Nat Struct Mol Biol. 19(7):716-718.

Honors, Awards and Fellowships:
1997¡¡Presidential Excellent Award, Chinese Academy of Sciences
1998¡¡Di’ao Scholarship, Chinese Academy of Sciences
1999¡¡Presidential Outstanding Award, Chinese Academy of Sciences
2001¡¡Excellent Ph.D. Thesis, China

Society Memberships:
Chinese Society of Biochemistry and Molecular Biology, Member
Society for Enzymology, CSBMB, Councilor
Chinese Crystallographic Society, Member

Mail: School of Life Sciences., Tsinghua University, Beijing 100084

Tsinghua University,Beijing,China,100084
Tel:+86-10-62788604  Fax:+86-10-62788604  Email:admin-life@biomed.tsinghua.edu.cn