Full time faculty

Adjunct professor

Chair professor

Administration

Wei Wu

Wei Wu
Ph.D Professor
 
1987-1991, Sichuan University, B.S.
1991-1994, Sichuan University, M.S.
1996-2001, University of Heidelberg, Ph.D
2001-2005, German Cancer Research Center, Postdoc
2005-present, Professor of Tsinghua University
 
Main Research Fields:
The Wnt signaling regulates cell growth, proliferation, differentiation and migration. It plays important roles during embryonic development as well as tumorigenesis. Using Xenopus, mouse, planarian as well as in vitro tissue and cell culture, we investigate the roles and molecular mechanisms of Wnt signaling during embryonic development, regeneration and tumorigenesis.
 
Selected Publications:
  1. Zhu G, Wang Y, Huang B, Liang J, Ding Y, Xu A, Wu W. A Rac1/PAK1 cascade controls beta-catenin activation in colon cancer cells. Oncogene. 2011 Aug 8. doi: 10.1038/onc.2011.294. [Epub ahead of print]
  2. Liang J, Fu Y, Cruciat CM, Jia S, Wang Y, Tong Z, Tao Q, Ingelfinger D, Boutros M, Meng A, Niehrs C, Wu W. Transmembrane Protein 198 Promotes LRP6 Phosphorylation and Wnt Signaling Activation. Mol Cell Biol. 2011 Jul;31(13):2577-90.
  3. Ma C, Wang X, Yu S, Chai G, Su H, Zheng L. Wu W. A small scale expression screen identifies tissue specific markers in the Dugesia japonica strain Pek-1. J Genet Genomics. 2010 Sep;37(9):621-35.   
  4. Chai G, Ma C, Bao K, Zheng L, Wang X, Sun Z, Salo E, Adell T, Wu W. Complete functional segregation of planarian beta-catenin-1 and -2 in mediating Wnt signaling and cell adhesion. J Biol Chem. 2010 Jul 30;285(31):24120-30.
  5. Wang Y, Fu Y, Gao L, Zhu G, Liang J, Gao C, Huang B, Fenger U, Niehrs C, Chen YG, Wu W. Xenopus skip modulates Wnt/beta-catenin signaling and functions in neural crest induction. J Biol Chem. 2010 Apr 2;285(14):10890-901.
  6. *Davidson G, *Wu W, Shen J, Bilic J, Fenger U, Stannek P, Glinka A, Niehrs C. Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature. 2005 Dec 8;438(7069):867-72. (*equal contribution)
  7. Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W. Rspo2 is a secreted activator of Wnt/β-catenin signalling and is required for Xenopus myogenesis. Dev Cell. 2004 Oct; 7(4): 525-34.
  8. *Mao B, *Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature. 2001 May 17; 411(6835):321-5. (*equal contribution)

Contact:
School of Life Sciences, Tsinghua University, 100084 Beijing
Tel: +86-10-62797127/5
E-mail: wwu@mail.tsinghua.edu.cn



Tsinghua University,Beijing,China,100084
Tel:+86-10-62772269  Fax:+86-10-62788604  Email:swxrs@tsinghua.edu.cn