Full time faculty

Adjunct professor

Chair professor

Administration

Daoxin Xie

Daoxin Xie Ph.D.

Professor, Cheung Kong Scholar, Winner of the National Science Foundation for Outstanding Young Scientists of China. Editorial board members of The Plant Journal, Molecular Plant, Journal of Integrative Plant Biology, and Science China Life Sciences

 

 

2006-present: Professor, Tsinghua University

2002-2006: Senior Scientist, Principal Investigator, Institute of Molecular and Cell Biology, Singapore

1999-2002: Senior Scientist, Principal Investigator, Institute of Molecular Agrobiology; Adjunct Assistant Professor, National University of Singapore

1994-1999: Senior Research Associate, University of East Anglia, UK

1990-1994: Postdoctoral Researcher, John Innes Centre; Leicester University, UK

1987-1990: Ph.D., Chinese Academy of Agricultural Sciences

1984-1987: MSc., Chinese Academy of Agricultural Sciences

1983-1984: Research Assistant, Hunan Cotton Research Institute

1979-1983: BSc., Hunan Agricultural College

 

 

Research Field

 

Understanding of hormone perception is central to comprehending hormone action. Over the past century, a general “ligand-receptor” interaction mechanism has been revealed for all classical hormone: receptors reversibly and non-covalently bind active hormone molecules to trigger signal transduction. Xie lab has been working on plant hormone signaling, and has revealed the receptors for jasmonate (JA) and strigolactone (SL): COI1 serves as a receptor for JA, and reversibly sense the active JA molecule (JA-Ile) to trigger JA-regulated plant defense and development; D14 acts as a non-canonical receptor for SL, which generates and irreversibly binds the active SL molecule (CLIM) to trigger SL-regulated plant development.

 

 

Selected publications

 

1.         Yao R, Wang F, Ming Z, Du X, Chen L, Wang Y, Zhang W, Deng H, Xie D. (2016) ShHTL7 is a non-canonical receptor for strigolactones in root parasitic weeds. Cell Research (in press).

2.         Wu D, Qi T, Li W, Tian H, Gao H, Wang J, Ge J, Yao R, Ren C, Wang X, Liu Y, Kang L, Ding S, Xie D. (2016) Viral effector protein manipulates host jasmonate signaling to attract insect vectors. Cell Research (in press).

3.         Yao R, Ming Z, Yan L, Li S, Wang F, Ma S, Yu C, Yang M, Chen L, Chen L, Li Y, Yan C, Miao D, Sun Z, Yan J, Sun Y, Wang L, Chu J, Fan S, He W, Deng H, Nan F, Li J, Rao Z, Lou Z and Xie D. (2016) DWARF14 is a non-canonical hormone receptor for strigolactone. Nature 536: 469-73. (Featured in Nature and Science Signaling)

4.         Qi T, Wang J, Huang H, Liu B, Gao H, Liu Y, Song S, Xie D. (2015) Regulation of Jasmonate-Induced Leaf Senescence by Antagonism between bHLH Subgroup IIIe and IIId Factors in Arabidopsis. Plant Cell 27:1634-49.

5.         Qi T, Huang H, Song S and Xie D. (2015) Control of Jasmonate-regulated Stamen Development and Seed Production by a bHLH-MYB Complex in Arabidopsis. Plant Cell 27:1620-33.

6.         Qi T, Huang H, Wu D, Yan J, Qi Y, Song S and Xie D. (2014). Arabidopsis DELLA and JAZ Proteins Bind the WD-repeat/bHLH/MYB Complex to Modulate Gibberellin and Jasmonate Signaling Synergy. Plant Cell 26:1118-33.

7.         Song S, Huang H, Gao H, Wang J, Wu D, Liu X, Yang S, Zhai Q, Li C, Qi T and Xie D. (2014) Interaction of MYC2 with EIN3 Modulates Antagonism between Jasmonate and Ethylene Signaling. Plant Cell 26: 263-79.

8.         Hu P, Zhou W, Cheng Z, Fan M, Wang L and Xie D. (2013) JAV1 controls Jasmonate-regulated plant defense. Molecular Cell 50:504-15 (cover story; featured in Mol. Cell)

9.         Song S, Qi T, Wasternack C. and Xie D. (2014). Jasmonate signaling and crosstalk with gibberellin and ethylene. Current Opinion in Plant Biology 21C:112-119.

10.      Yan J., Li H., Li S., Yao R, Deng H., Xie Q. and Xie D. (2013) The Arabidopsis F-box protein CORONATINE INSENSITIVE 1 is stabilized by SCFCOI1 and degraded via the 26S proteasome pathway. Plant Cell 25: 486-98. (recommended by Faculty 1000)

11.      Song S, Qi T, Fan M, Zhang X, Gao H, Huang H, Wu D, Guo H, Xie D. (2013) The bHLH Subgroup IIId Factors Negatively Regulate Jasmonate-mediated Plant Defense and Development. PLoS Genetics 9, e1003653.

12.      Qi T, Song S, Ren Q, Wu D, Huang H, Chen Y, Fan M, Peng W, Ren C and Xie D. (2011) The Jasmonate-ZIM-domain Proteins Interact with the WD-repeat/bHLH/MYB Complexes to Control Jasmonate-regulated Anthocyanin Accumulation and Trichome Initiation in Arabidopsis. Plant Cell 23:1795-814.

13.     Shan X, Yan J, Xie D. (2012) Comparison of phytohormone signaling mechanisms. Current Opinion in Plant Biology 15(1):84-91.

14.      Song S, Qi T, Huang H, Ren Q, Wu D, Chang C, Peng W, Liu Y, Peng J and Xie D. (2011) The Jasmonate-ZIM-domain Proteins Interact with the R2R3-MYB Transcription Factors MYB21 and MYB24 to Control Jasmonate-regulated Stamen Development in Arabidopsis. Plant Cell 23:1000-13.

15.      Yan J, Zhang C, Gu M, Bai Z, ZhangW, Qi T, Cheng Z, Peng W, Luo H, Nan F, Wang Z, Xie D. (2009) The Arabidopsis CORONATINE INSENSITIVE 1 protein is a jasmonate receptor. Plant Cell 21: 2220-36 (recommended by Faculty 1000, featured in Nat. Chem. Bio. and Plant Cell)

16.      Cheng H, Song S, Xiao L, Soo H, Cheng Z, Xie D and Peng J. (2009) Gibberellin Acts Through Jasmonate to Control the Expression of MYB21, MYB24 and MYB57 to Promote Stamen Filament Growth in Arabidopsis. PLoS Genetics 5(3):e1000440.

17.      Tan L, Li X, Liu F, Sun X, Li C, Zhu Z, Fu Y, Cai H, Wang X, Xie D and Sun C. (2008) Control of a key transition from prostrate to erect growth in rice domestication. Nature Genetics 40:1360-4.

18.      Xiao S, Dai L, Liu L, Wang Z, Peng W, Xie D. (2004) COS1: an Arabidopsis coi1 suppressor essential forregulation of jasmonate-mediated plant defense and senescence. Plant Cell 16: 1132-42.

19.      Liu F, Ni W, Griffith M E, Huang Z, Chang C, Peng W, Ma H and Xie D. (2004) The ASK1 and ASK2 Genes Are Essential for Arabidopsis Early Development. Plant Cell 16:5-20.

20.      Xu L, Liu F, Lechner E, Genschik P, Crosby W L, Ma H, Peng W, Huang D and Xie D. (2002) The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. Plant Cell 14:1919-35.

21.      Xie D, Feys F, James S, Nieto-Rostro M and Turner J. (1998) COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertility. Science 280:1091-4.

 

 

Contact

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E-mail: daoxinlab(at)tsinghua(dot)edu(dot)cn



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