Full time faculty

Adjunct professor

Chair professor


Shuping Zhang




Shuping Zhang£¬Ph.D.



1998, China Agricultural University, Ph.D.;

1998-2002, Tsinghua University£¬University of Georgia, Yale University, post-doctoral fellow/visiting scholar;

2000-Present, School of Life Sciences, Tsinghua University.


Research field and interests

To understand the molecular mechanism of cell signaling using mammalian cells and mouse model, especially focusing on two aspects: 1. The function of MGARP gene; 2. The function of NOK/STYK1 in tumorigenesis and metastasis and the cellular signaling network.


Selected publications (Corresponding author)

  1. NOK/STYK1 promotes the genesis and remodeling of blood and lymphatic vessels during tumor progression.Liu Y, Li T, Hu D, Zhang S(P). Biochem Biophys Res Commun. 2016, 478(1):254-9.
  2. Jia L, Liang T, Yu X, Ma C, Zhang S(P). MGARP regulates mouse neocortical development via mitochondrial positioning. Mol Neurobiol. 2014, 49(3):1293–1308.
  3. Zhou M#, Liang T#, Wang Y, Jin D, Wang J, Jia L, Zhang S(P. Expression and tissue localization of renalase, a novel soluble FAD-dependent protein, in reproductive/steroidogenic systems. Mol Biol Rep. 2013, 40:3987–3994. (#Equal contribution)
  4. Jin D, Li R, Mao D, Luo N, Wang Y, Chen S, Zhang S(P). Mitochondria-localized glutamic acid-rich protein (MGARP) gene transcription is regulated by Sp1. PloS ONE. 2012 , 7 ( 11) e50053
  5. Li J, Wu F, Sheng F, Li YJ, Jin D, Ding X, Zhang S(P). NOK/STYK1 interacts with GSK-3β and mediates Ser9 phosphorylation through activated Akt. FEBS letters. 2012( 586) 3787–3792
  6. Ding X, Jiang QB, Li R, Chen S, Zhang S(P). NOK/STYK1 has a strong tendency towards forming aggregates and colocalises with epidermal growth factor receptor in endosomes, Biochem Biophys Res Commun. 2012, 421: 468–473.
  7. Zhou M#, Wang Y#, Qi S, Wang J, Zhang S(P). A mitochondria-localized glutamic acid-rich protein is involved in HPG axis. Endocrinology. 2011, 152(6):2311-20. (#Equal contribution)
  8. Qi S, Wang Y, Zhou M, Ge Y, Yan Y, Wang J, Zhang SS, Zhang S(P). A mitochondria-localized glutamic acid-rich protein (MGARP/OSAP) is highly expressed in retina that exhibits a large area of intrinsic disorder. Mol Biol Rep. 2011, 38:2869-2877.
  9. Wang J£¬Qi SL, Cheng W, Li L, Wang F, Li YZ, Zhang S(P). Identification, expression and tissue distribution of a renalase homologue from mouse, Mol Biol Rep. 2008, 35:613-20.
  10. Zhang S(P). A research-project-based and self-determined teaching system of molecular biology techniques for undergraduates, BMBE, 2008, 36(3):181-8.
  11. Li YH, Zhong S, Rong ZL, Ren YM, Li ZY, Zhang S(P), Chang Z, Liu L. The carboxyl terminal tyrosine 417 residue of NOK has an autoinhibitory effect on NOK-mediated signaling transductions. Biochem Biophys Res Commun. 2007, 356(2):444-9.
  12. Chen Y, Li YH, Chen XP, Gong LM, Zhang S(P), Chang ZJ, Zhang XF, Fu XY, Liu L.Point mutation at single tyrosine residue of novel oncogene NOK abrogates tumorigenesis in nude mice. Cancer Res. 2005, 65(23):10838-46.
  13. Li YH, Wang YY, Zhong S, Rong ZL, Ren YM, Li ZY, Zhang S(P), Chang ZJ, Liu L. Transmembrane helix of novel oncogene with kinase-domain (NOK) influences its oligomerization and limits the activation of RAS/MAPK signaling. Mol Cells. 2009, 27(1):39-45. 
  14. Zhang Y, Li T, Fu L, Yu C, Li Y, Xu X, Wang Y, Ning H, Zhang S, Chen W, Babiuk LA, Chang Z. Silencing SARS-CoV Spike protein expression in cultured cells by RNA interference£¬Biochem Biophys Res Commun. 2004,26;324(4):1186-93.
  15. Liu L, Yu XZ, Li TS, Song LX, Chen PL, Suo TL, Li YH, Wang SD, Chen Y, Ren YM, Zhang S(P), Chang ZJ, Fu XY. A novel protein tyrosine kinase NOK that shares homology with platelet-derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice. Cancer Res. 2004, 64(10):3491-9.
  16. Li L, Xin H, Xu X, Huang M, Zhang X, Chen Y, Zhang S(P), Fu XY, Chang Z. CHIP Mediates Degradation of Smad Proteins and Potentially Regulates Smad-Induced Transcription. Mol Cell Biol. 2004, 24(2):856-864.
  17. Xiong S, Zhao Q, Rong Z, Huang G, Huang Y, Chen P, Zhang S(P), Liu L, Chang Z. hSef inhibits PC12 cell differentiation by interfering with Ras-MAPK signaling, J Biol Chem. 2003,278: 50273-50282.



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E-mail: bczhang@mail.tsinghua.edu.cn/shpzhang@biomed.tsinghua.edu.cn



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